2017
Metallothionein polymorphisms in a Northern Spanish population with neovascular and dry forms of age-related macular degeneration
García M, Álvarez L, Fernández Á, González-Iglesias H, Escribano J, Fernández-Vega B, Villota E, Cueto L, Fernández-Vega Á, Coca-Prados M. Metallothionein polymorphisms in a Northern Spanish population with neovascular and dry forms of age-related macular degeneration. Ophthalmic Genetics 2017, 38: 451-458. PMID: 28635422, DOI: 10.1080/13816810.2017.1288825.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeGenotyping TechniquesGeographic AtrophyHumansMaleMetallothioneinMiddle AgedPolymerase Chain ReactionPolymorphism, Single NucleotideSpainWet Macular DegenerationConceptsAge-related macular degenerationDry age-related macular degenerationSingle nucleotide polymorphismsMT genesMacular degenerationNorthern Spanish populationHaploView 4.0 softwareNorthern Spanish patientsCase-control studySpanish populationMetallothionein genePeripheral bloodHealthy controlsAMD subjectsAssociation studiesSpanish patientsGenesPotential associationSignificant associationNucleotide polymorphismsGenotype AGControl cases
2016
Metallothionein polymorphisms in a Northern Spanish population with Age‐Related Macular Degeneration (AMD)
Garcia M, Álvarez L, Fernandez Á, Gonzalez‐Iglesias H, Escribano J, Fernandez‐Vega B, Fernandez‐Vega Á, Villota E, Fernandez‐Vega L, Coca‐Prados M. Metallothionein polymorphisms in a Northern Spanish population with Age‐Related Macular Degeneration (AMD). Acta Ophthalmologica 2016, 94 DOI: 10.1111/j.1755-3768.2016.0531.Peer-Reviewed Original ResearchAge-related macular degenerationSingle nucleotide polymorphismsMacular degenerationSignificant associationNorthern Spanish populationDry AMD casesHaploView 4.0 softwareNorthern Spanish patientsCase-control studySpanish populationUnique significant associationsPeripheral bloodHealthy controlsAMD subjectsMT2A geneSpanish patientsAllelic frequency analysisAMD casesConferring protectionPotential associationAllele GRs28366003Potential roleSignificant differencesMT genes
2013
Metallothioneins (MTs) in the human eye: a perspective article on the zinc–MT redox cycle
Gonzalez-Iglesias H, Alvarez L, García M, Petrash C, Sanz-Medel A, Coca-Prados M. Metallothioneins (MTs) in the human eye: a perspective article on the zinc–MT redox cycle. Metallomics 2013, 6: 201-208. PMID: 24419560, DOI: 10.1039/c3mt00298e.Peer-Reviewed Original ResearchConceptsCellular zinc homeostasisOxidative damageAntioxidant functionMT genesMultiple isoformsReactive oxygen speciesPotential oxidative damageDe novo synthesisZinc homeostasisAntioxidant defense mechanismsMain regulatorDefense mechanismsNovo synthesisProtein expressionOxygen speciesExogenous zincZn7-MTMetallothioneinOxidative stressMT complexZinc releaseStoichiometric transitionsZinc-MTPro-inflammatory cytokinesLevels of metallothionein