2024
Neuroendocrine Properties of the Ciliary Epithelium
Coca-Prados M. Neuroendocrine Properties of the Ciliary Epithelium. 2024 DOI: 10.1016/b978-0-443-13820-1.00083-9.Peer-Reviewed Original ResearchGene expressionExpression of bioactive peptidesIdentity of genesGene expression of enzymesMicroarray-based analysisExpression of enzymesSensor proteinsRegulate metabolismGenesPhysiological processesCiliary epitheliumPhysiological functionsT4 to T3Neuronal Ca2Neuroendocrine propertiesVasoconstrictive functionVasoactive aminesPeptide receptorBioactive peptidesIon channelsMetabolismPeptideEyesEnzymeProtein
2016
The zinc‐metallothionein redox system in human retina and RPE
Alvarez L, García M, Rodríguez S, Fernández B, Pereiro R, Sanz‐Medel A, Coca‐Prados M, González‐Iglesias H. The zinc‐metallothionein redox system in human retina and RPE. Acta Ophthalmologica 2016, 94 DOI: 10.1111/j.1755-3768.2016.0560.Peer-Reviewed Original ResearchHuman RPE cellsInflammatory cytokinesNeuroprotective functionOxidative stress processesEye sectionsNeural retinaHuman donorsRPE cellsRetinaHuman retinaHuman eyeRPEMT proteinExogenous zincCellular zinc homeostasisCellular modelZinc homeostasisMain regulatorStoichiometric transitionsEyesBinding profileProtein binding profileProtein synthesisLesser levelsMetallothionein
2015
A Renal-Like Organic Anion Transport System in the Ciliary Epithelium of the Bovine and Human Eye
Lee J, Shahidullah M, Hotchkiss A, Coca-Prados M, Delamere NA, Pelis RM. A Renal-Like Organic Anion Transport System in the Ciliary Epithelium of the Bovine and Human Eye. Molecular Pharmacology 2015, 87: 697-705. PMID: 25661037, PMCID: PMC6067639, DOI: 10.1124/mol.114.096578.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological Transport, ActiveCattleCiliary BodyDicarboxylic Acid TransportersHumansKidney CortexMultidrug Resistance-Associated ProteinsOrganic Anion Transport Protein 1Organic Anion TransportersOrganic Anion Transporters, Sodium-DependentOrganic Anion Transporters, Sodium-IndependentRetinal Pigment EpitheliumRNA, MessengerSymportersConceptsCiliary bodyAqueous humorPara-aminohippurateUssing chambersOcular tissuesReverse transcription-polymerase chain reactionOrganic anion transport systemHuman ocular tissuesBovine ciliary bodyHuman ciliary bodyPerfused eyePolymerase chain reactionBasolateral membraneEye preparationsTransporter expressionOrganic anion transportCiliary epitheliumAnion transport systemHuman eyeEpithelial cellsChain reactionBlood sideBlood directionEyesBarrier epithelia
2014
The Blood-Aqueous Barrier in Health and Disease
Coca-Prados M. The Blood-Aqueous Barrier in Health and Disease. Journal Of Glaucoma 2014, 23: s36-s38. PMID: 25275903, DOI: 10.1097/ijg.0000000000000107.Peer-Reviewed Original ResearchConceptsBlood-aqueous barrierTight junctionsInflammatory ocular diseasesBlood-borne moleculesInner wall endotheliumInflammatory cellsBarrier dysfunctionVascular leakagePharmacologic agentsAnterior segmentOcular diseasesSchlemm's canalIris vasculatureCiliary processesEndothelial cellsJunctional complexesGap junctionsParacellular transportPhysiological changesDiseaseEyesCanalCellsApical junctional complex
1997
The prostaglandin transporter is widely expressed in ocular tissues
Schuster V, Lu R, Coca-Prados M. The prostaglandin transporter is widely expressed in ocular tissues. Survey Of Ophthalmology 1997, 41: s41-s45. PMID: 9154275, DOI: 10.1016/s0039-6257(97)80006-9.Peer-Reviewed Original Research