2023
Identifying Pregnancies at Higher Risk for HPA-1a Alloimmunization and Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT): An International, Prospective, Natural History Study
Vander Haar E, Ware C, Allen G, Armstrong R, Black D, Bombara M, Dhanraj D, Lawrence L, Miller R, Nanda S, Paidas M, Patki K, Sitras V, Skupski D, Swarup M, Thorp J, Tiller H, Verweij J, Bussel J. Identifying Pregnancies at Higher Risk for HPA-1a Alloimmunization and Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT): An International, Prospective, Natural History Study. Blood 2023, 142: 1224. DOI: 10.1182/blood-2023-177657.Peer-Reviewed Original ResearchFetal/Neonatal Alloimmune ThrombocytopeniaHPA-1a alloimmunizationNeonatal alloimmune thrombocytopeniaPregnant womenHuman platelet antigensNatural history studiesFetal deathNeonatal thrombocytopeniaSecond trimesterPlatelet countAlloimmune thrombocytopeniaRisk pregnanciesWeek 10HPA-1a negative womenAdministration of prophylaxisAntenatal intravenous immunoglobulinHPA-1bb womenLifelong neurological impairmentMultiple European centersSevere neonatal thrombocytopeniaHigh-risk womenSingle-arm studyFetal platelet countGestational weeks 10First epidemiological study
2010
Hematologic Changes in Pregnancy
Paidas M, Hossain N. Hematologic Changes in Pregnancy. 2010, 1-11. DOI: 10.1002/9781444328332.ch1.Peer-Reviewed Original ResearchWeeks of gestationHemoglobin levelsThird trimesterPregnant womenTotal white blood cellsMajor hematological changesRed blood cell massAbsolute lymphocyte countCells/microL.Healthy nonpregnant womenHealthy pregnant womenEnd of pregnancyBlood cell massWhite blood cellsPlasma volume increasePhysiologic anemiaLymphocyte countNeutrophil countNonpregnant womenPlatelet countProcoagulant factorsSecond trimesterNonpregnant levelsHematologic changesMild thrombocytopeniaMaternal and Fetal Thrombocytopenia
Paidas M, Hossain N. Maternal and Fetal Thrombocytopenia. 2010, 41-66. DOI: 10.1002/9781444328332.ch4.Peer-Reviewed Original ResearchNeonatal alloimmune thrombocytopeniaFetal thrombocytopeniaNeonatal thrombocytopeniaMaternal thrombocytopeniaFetal plateletsAlloimmune thrombocytopeniaFetus/neonateContext of pregnancyFetal platelet functionPrompt recognitionIntracranial hemorrhagePlatelet countFuture pregnanciesForeign antigensPlatelet functionThrombocytopeniaPregnancyPregnancy stateGenetic disordersNeonatesAntigenPlatelets resultsAntibodiesDisordersMothers
1996
Antenatal management of alloimmune thrombocytopenia with intravenous γ-globulin: A randomized trial of the addition of low-dose steroid to intravenous γ-globulin
Bussel J, Berkowitz R, Lynch L, Lesser M, Paidas M, Huang C, McFarland J. Antenatal management of alloimmune thrombocytopenia with intravenous γ-globulin: A randomized trial of the addition of low-dose steroid to intravenous γ-globulin. American Journal Of Obstetrics And Gynecology 1996, 174: 1414-1423. PMID: 9065105, DOI: 10.1016/s0002-9378(96)70582-3.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageDexamethasoneDose-Response Relationship, DrugDrug Therapy, CombinationFemaleFetal BloodFetal DiseasesHumansImmunoglobulins, IntravenousIsoantibodiesMaternal-Fetal ExchangePlatelet CountPrednisonePregnancyProspective StudiesSalvage TherapyThrombocytopeniaTreatment OutcomeConceptsIntravenous γ-globulinAlloimmune thrombocytopeniaThrombocytopenic fetusesIntracranial hemorrhageIntravenous gamma globulin treatmentGamma globulin treatmentLow-dose steroidsUtero platelet transfusionsFetal blood samplingMaternal infusionAntenatal managementSevere thrombocytopeniaΓ-globulinPlatelet countPlatelet transfusionsBlood samplingFetal bloodThrombocytopeniaPlatelet increaseDexamethasoneFetusesGm/PrednisoneNonrespondersHemorrhage
1995
Alloimmune thrombocytopenia: Fetal and neonatal losses related to cordocentesis
Paidas M, Berkowitz R, Lynch L, Lockwood C, Lapinski R, McFarland J, Bussel J. Alloimmune thrombocytopenia: Fetal and neonatal losses related to cordocentesis. American Journal Of Obstetrics And Gynecology 1995, 172: 475-479. PMID: 7856672, DOI: 10.1016/0002-9378(95)90559-6.Peer-Reviewed Original ResearchConceptsAlloimmune thrombocytopeniaExact testNeonatal lossAntenatal intracranial hemorrhageMean platelet countMulticenter treatment studyFisher's exact testResult of exsanguinationWilcoxon rank sum testRank sum testFatal exsanguinationIntracranial hemorrhageNeonatal deathPlatelet countCordocentesisTreatment studiesThrombocytopeniaFetusesUntreated siblingsLaboratory data