2012
Inherited and Acquired Thrombophilias
Paidas M. Inherited and Acquired Thrombophilias. 2012, 108-120. DOI: 10.1002/9781119963783.ch15.Peer-Reviewed Original ResearchAntiphospholipid antibody syndromePlacenta-mediated complicationsAntibody syndromeThrombophilic conditionsProthrombin G20210A gene mutationFactor V Leiden mutationBenefits of anticoagulationCornerstone of treatmentProspective cohort studyRecurrent pregnancy lossAdequate clinical trialsV Leiden mutationAcquired ThrombophiliaAntiplatelet therapyCohort studyPregnancy lossThrombophilic mutationsClinical trialsLeiden mutationNatural anticoagulantsRoutine useThrombophiliaGene mutationsAnticoagulationComplications
2010
WAG‐F8m1Ycb rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A
BOOTH CJ, BROOKS MB, ROCKWELL S, MURPHY JW, RINDER HM, ZELTERMAN D, PAIDAS MJ, COMPTON SR, MARKS PW. WAG‐F8m1Ycb rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A. Journal Of Thrombosis And Haemostasis 2010, 8: 2472-2477. PMID: 20626616, DOI: 10.1111/j.1538-7836.2010.03978.x.Peer-Reviewed Original ResearchConceptsAutosomal locationX chromosomeGenetic basisFactor VIIITertiary structureChromosome 18Point mutationsA1 domainFactor activityGenetic defectsHuman recombinant factor VIIIPartial thromboplastin timeSpecific coagulation factorsNew animal modelNormal prothrombin timeFactor VIII gene mutationsRecombinant factor VIIIMutationsPeripartum deathsGene mutationsCoagulation abnormalitiesSpontaneous bruisingProthrombin timeFemale ratsNovel therapies