2018
Peptide-Mediated Neurotransmission Takes Center Stage
Gonzalez-Suarez AD, Nitabach MN. Peptide-Mediated Neurotransmission Takes Center Stage. Trends In Neurosciences 2018, 41: 325-327. PMID: 29801523, PMCID: PMC5975383, DOI: 10.1016/j.tins.2018.03.013.Peer-Reviewed Original Research
2017
A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity
King AN, Barber AF, Smith AE, Dreyer AP, Sitaraman D, Nitabach MN, Cavanaugh DJ, Sehgal A. A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity. Current Biology 2017, 27: 1915-1927.e5. PMID: 28669757, PMCID: PMC5698909, DOI: 10.1016/j.cub.2017.05.089.Peer-Reviewed Original ResearchConceptsLocomotor activitySubesophageal zonePeptidergic circuitsPars intercerebralisCorticotropin-releasing factorVentral nerve cordSite of actionReceptor 1Motor outputCircadian locomotor activityNerve cordNeuronsRelevant receptorsDrosophila brainHr rhythmsCircadian driveRhythmFeeding rhythmDiuretic hormone 44Minimal effectActivity rhythmsBehavioral rhythmsCircadian locomotionCircadian controlCord
2016
Neural Architecture of Hunger-Dependent Multisensory Decision Making in C. elegans
Ghosh DD, Sanders T, Hong S, McCurdy LY, Chase DL, Cohen N, Koelle MR, Nitabach MN. Neural Architecture of Hunger-Dependent Multisensory Decision Making in C. elegans. Neuron 2016, 92: 1049-1062. PMID: 27866800, PMCID: PMC5147516, DOI: 10.1016/j.neuron.2016.10.030.Peer-Reviewed Original Research
2013
Pigment-Dispersing Factor Modulates Pheromone Production in Clock Cells that Influence Mating in Drosophila
Krupp JJ, Billeter JC, Wong A, Choi C, Nitabach MN, Levine JD. Pigment-Dispersing Factor Modulates Pheromone Production in Clock Cells that Influence Mating in Drosophila. Neuron 2013, 79: 54-68. PMID: 23849197, PMCID: PMC3955580, DOI: 10.1016/j.neuron.2013.05.019.Peer-Reviewed Original ResearchConceptsPigment Dispersing FactorClock cellsMating behaviorPheromone productionNeuropeptide Pigment Dispersing FactorPeripheral clock cellsMale sex pheromoneSex pheromone productionMolecular rhythmsPhysiological outputsNeuropeptide signalingBehavioral rhythmsCircadian mechanismsSex-specific differencesDrosophilaSex pheromoneCircadian entrainmentOenocytesCircadian systemPheromonePathwayNeuroendocrine pathwaysActivity rhythmsCellsBehavioral processesA biogenic amine and a neuropeptide act identically: tyramine signals through calcium in Drosophila tubule stellate cells
Cabrero P, Richmond L, Nitabach M, Davies SA, Dow JA. A biogenic amine and a neuropeptide act identically: tyramine signals through calcium in Drosophila tubule stellate cells. Proceedings Of The Royal Society B 2013, 280: 20122943. PMID: 23446525, PMCID: PMC3619477, DOI: 10.1098/rspb.2012.2943.Peer-Reviewed Original ResearchMeSH KeywordsAequorinAnimalsApoproteinsCalcium SignalingChloridesDrosophila melanogasterDrosophila ProteinsGreen Fluorescent ProteinsInositol 1,4,5-Trisphosphate ReceptorsMalpighian TubulesModels, BiologicalNeuropeptidesPhospholipase C betaProtein EngineeringRecombinant ProteinsTyramineWater-Electrolyte BalanceConceptsTrisphosphate receptor geneCalcium signalsStellate cellsTranslational fusionInsect osmoregulationDistinct tissuesIntracellular calciumMode of actionPhospholipase CIntracellular calcium signalsReceptor geneIndependent mechanismsHalf-maximal activationTyramine-induced increaseUAS controlITPRTyramine actEndocrine controlRenal functionCellsNeuropeptides actPrincipal cellsKininsDrosophilaNorpA
2012
Peptide Neuromodulation in Invertebrate Model Systems
Taghert PH, Nitabach MN. Peptide Neuromodulation in Invertebrate Model Systems. Neuron 2012, 76: 82-97. PMID: 23040808, PMCID: PMC3466441, DOI: 10.1016/j.neuron.2012.08.035.Peer-Reviewed Original ResearchConceptsInvertebrate model systemsGenetic model organism Drosophila melanogasterModel organism Drosophila melanogasterAdaptive animal behaviourModel systemCaenorhabditis elegansDrosophila melanogasterPhysiological processesReproductive behaviorSophisticated behavioral paradigmsPhysiological approachAnimal behaviorCircadian rhythmNeuropeptide modulationMelanogasterElegansInsectsNeural circuitsCircuit functionCrustaceansNematodesMollusksPeptide neuromodulationCentral pattern generationNeuropeptides
2011
Tethering toxins and peptide ligands for modulation of neuronal function
Ibañez-Tallon I, Nitabach MN. Tethering toxins and peptide ligands for modulation of neuronal function. Current Opinion In Neurobiology 2011, 22: 72-78. PMID: 22119144, PMCID: PMC3294089, DOI: 10.1016/j.conb.2011.11.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsLigandsNeuropeptidesNeurosciencesNeurotoxinsProtein EngineeringReceptors, NicotinicInsect circadian clock outputs
Helfrich-Förster C, Nitabach MN, Holmes TC. Insect circadian clock outputs. Essays In Biochemistry 2011, 49: 87-101. PMID: 21819386, DOI: 10.1042/bse0490087.Peer-Reviewed Original ResearchConceptsClock neuronsDaily rhythmsCircadian clock outputBrain clockCellular clocksDrosophila fliesCircadian timekeeping systemCircadian outputEnvironmental cuesClock outputMigratory locustInsectsTimekeeping systemCircadian rhythmicitySubstantial similarityClockImpressive varietyButterfliesLocal environmentFliesClock circuitEntire lifeLocustTimekeeperPhysiology