Negative Autoregulation by FAS Mediates Robust Fetal Erythropoiesis
Socolovsky M, Murrell M, Liu Y, Pop R, Porpiglia E, Levchenko A. Negative Autoregulation by FAS Mediates Robust Fetal Erythropoiesis. PLOS Biology 2007, 5: e252. PMID: 17896863, PMCID: PMC1988857, DOI: 10.1371/journal.pbio.0050252.Peer-Reviewed Original ResearchConceptsDeath receptor FASRed cell progenitorsAutoregulatory interactionsEmbryos mutantErythroid developmentPivotal negative regulatorNegative autoregulationFetal erythropoiesisErythroid tissuesDevelopmental processesNegative regulatorTissue developmentEarly erythroblastsSimilar maturation stageCell progenitorsIntercellular interactionsDevelopmental rateRegulatory feedbackRobust homeostasisEmbryonic day 12Novel computational algorithmMaturation stageProgenitorsApoptosisFAS