High‐content imaging with micropatterned multiwell plates reveals influence of cell geometry and cytoskeleton on chromatin dynamics
Harkness T, McNulty J, Prestil R, Seymour S, Klann T, Murrell M, Ashton R, Saha K. High‐content imaging with micropatterned multiwell plates reveals influence of cell geometry and cytoskeleton on chromatin dynamics. Biotechnology Journal 2015, 10: 1555-1567. PMID: 26097126, PMCID: PMC6948850, DOI: 10.1002/biot.201400756.Peer-Reviewed Original ResearchConceptsChromatin dynamicsHigh-content imagingMicroenvironmental cuesHuman cellsCellular microenvironment influencesHuman cell biologySingle cell geometryCell-cell contactExtracellular matrix connectionsActin cytoskeletonHuman cell behaviorCytoskeletal organizationHigh-content screening technologyCell biologyBiophysical cuesCellular responsesCellular microenvironmentNuclear elongationCell behaviorCellular biophysicsSubcellular imagingComplex milieuCellular geometryHuman fibroblastsCytoskeleton