2022
Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunction
Xing H, Huang Y, Kunkemoeller B, Dahl P, Muraleetharan O, Malvankar N, Murrell M, Kyriakides T. Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunction. Scientific Reports 2022, 12: 22474. PMID: 36577792, PMCID: PMC9797577, DOI: 10.1038/s41598-022-26337-1.Peer-Reviewed Original ResearchConceptsCell-derived matricesCell stiffnessFamily verprolin-homologous protein 2Active Rac1Thrombospondin-2Homologous protein 2Less traction forceCytoskeleton organizationExtracellular matrix productionMajor cell populationF-actinCytoskeletal disorganizationRegulatory roleProtein 2Matrix productionCritical functionsECM productionArt microscopy techniquesNew functionsCell populationsSpindle-like shapeRac1Normal fibroblastsFibroblastsWound space
2014
How cells flow in the spreading of cellular aggregates
Beaune G, Stirbat T, Khalifat N, Cochet-Escartin O, Garcia S, Gurchenkov V, Murrell M, Dufour S, Cuvelier D, Brochard-Wyart F. How cells flow in the spreading of cellular aggregates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 8055-8060. PMID: 24835175, PMCID: PMC4050549, DOI: 10.1073/pnas.1323788111.Peer-Reviewed Original Research