2024
Confinement induces internal flows in adherent cell aggregates
Yousafzai M, Amiri S, Sun Z, Pahlavan , Murrell M. Confinement induces internal flows in adherent cell aggregates. Journal Of The Royal Society Interface 2024, 21: 20240105. PMID: 38774959, PMCID: PMC11285874, DOI: 10.1098/rsif.2024.0105.Peer-Reviewed Original Research
2022
Interplay between substrate rigidity and tissue fluidity regulates cell monolayer spreading
Staddon M, Murrell M, Banerjee S. Interplay between substrate rigidity and tissue fluidity regulates cell monolayer spreading. Soft Matter 2022, 18: 7877-7886. PMID: 36205535, PMCID: PMC9700261, DOI: 10.1039/d2sm00757f.Peer-Reviewed Original ResearchConceptsSubstrate rigidityCollective cell motionSubstrate stiffnessTissue fluidityStiff substratesCell-matrix adhesionTraction force generationCell-cell interactionsCell motionTissue morphogenesisSoft elastic matrixCell collectivesEmbryonic developmentCell crawlingCell spreadingCell monolayersSolid tissuesCell behaviorMechanical behaviorPredictive understandingMechanical propertiesCancer invasionCell aggregatesElastic matrixCell propertiesCell-Matrix Elastocapillary Interactions Drive Pressure-Based Wetting of Cell Aggregates
Yousafzai M, Yadav V, Amiri S, Staddon M, Errami Y, Jaspard G, Banerjee S, Murrell M. Cell-Matrix Elastocapillary Interactions Drive Pressure-Based Wetting of Cell Aggregates. Physical Review X 2022, 12: 031027. PMID: 38009085, PMCID: PMC10673637, DOI: 10.1103/physrevx.12.031027.Peer-Reviewed Original ResearchCapillary forcesCompliant substratesCapillary effectsRigid substrateData-driven modelingInternal pressureInterfacial tensionBulk elasticityCell surface tensionCell aggregatesSurface tensionActive dropletsMechanical stressCellular length scalesLength scalesComputational simulationsCollective cell motionDrive pressureWettingTissue shapeAdhesive substrateSubstrateElastocapillaryCell motionElasticity