2024
Active tension and membrane friction mediate cortical flows and blebbing in a model actomyosin cortex
Sakamoto R, Murrell M. Active tension and membrane friction mediate cortical flows and blebbing in a model actomyosin cortex. Physical Review Research 2024, 6: 033024. DOI: 10.1103/physrevresearch.6.033024.Peer-Reviewed Original ResearchActomyosin cortexCell membraneActin cytoskeletonCortical flowMembrane blebbingCell divisionCell migrationCytoskeletonActomyosinBiological phenomenaMembrane bulgesBlebsCellsMembraneViscoelastic fluidMechanical responseElastic stressesStress yieldActinUbiquitous structuresApoptosisMechanical stressMembrane elasticityPhysical behavior
2007
Negative Autoregulation by FAS Mediates Robust Fetal Erythropoiesis
Socolovsky M, Murrell M, Liu Y, Pop R, Porpiglia E, Levchenko A. Negative Autoregulation by FAS Mediates Robust Fetal Erythropoiesis. PLOS Biology 2007, 5: e252. PMID: 17896863, PMCID: PMC1988857, DOI: 10.1371/journal.pbio.0050252.Peer-Reviewed Original ResearchConceptsDeath receptor FASRed cell progenitorsAutoregulatory interactionsEmbryos mutantErythroid developmentPivotal negative regulatorNegative autoregulationFetal erythropoiesisErythroid tissuesDevelopmental processesNegative regulatorTissue developmentEarly erythroblastsSimilar maturation stageCell progenitorsIntercellular interactionsDevelopmental rateRegulatory feedbackRobust homeostasisEmbryonic day 12Novel computational algorithmMaturation stageProgenitorsApoptosisFAS
2004
The Systems Biology of Glycosylation
Murrell M, Yarema K, Levchenko A. The Systems Biology of Glycosylation. ChemBioChem 2004, 5: 1334-1347. PMID: 15457533, DOI: 10.1002/cbic.200400143.Peer-Reviewed Original ResearchConceptsSystems biologyRegulation of differentiationRegulation of glycosylationEukaryotic cellsBiochemical systems analysisCell regulation processesCell decisionsSignal transductionGlycosylationBiologyRegulation processesRegulationTransductionApoptosisDifferentiationProfound influenceCellsNovel research methodology