1986
A Review of Nephrotic Syndrome Associated With Chronic Lymphocytic Leukemia
Seney F, Federgreen W, Stein H, Kashgarian M. A Review of Nephrotic Syndrome Associated With Chronic Lymphocytic Leukemia. JAMA Internal Medicine 1986, 146: 137-141. PMID: 3942445, DOI: 10.1001/archinte.1986.00360130167023.Peer-Reviewed Original ResearchConceptsChronic lymphocytic leukemiaNephrotic syndromeLymphocytic leukemiaNephrotic Syndrome AssociatedCommon glomerular lesionImmune complex diseaseRenal diseaseMembranoproliferative glomerulonephritisCellular immunitySyndrome AssociatedGlomerular lesionsImmunoglobulin productionPatientsAvailable evidenceSyndromeLeukemiaDiseaseGlomerulonephritisLesionsImmunity
1985
Pathology of Small Blood Vessel Disease in Hypertension
Kashgarian M. Pathology of Small Blood Vessel Disease in Hypertension. American Journal Of Kidney Diseases 1985, 5: a104-a110. PMID: 2581443, DOI: 10.1016/s0272-6386(85)80072-x.Peer-Reviewed Original ResearchConceptsHyaline arteriolosclerosisPerpetuation of hypertensionSmall blood vessel diseaseBlood vessel diseasesArteriolar diseaseMyointimal hyperplasiaVessel diseasePathogenic rolePathophysiologic consequencesAnatomic correlatesHypertensionTransmural pressureArteriolosclerosisLesionsDiseaseExtracellular matrixArteriolonecrosisHyperplasiaArteriolesPathogenesisTherapyPathologyLyme arthritis. Spirochetes found in synovial microangiopathic lesions.
Johnston Y, Duray P, Steere A, Kashgarian M, Buza J, Malawista S, Askenase P. Lyme arthritis. Spirochetes found in synovial microangiopathic lesions. American Journal Of Pathology 1985, 118: 26-34. PMID: 3966535, PMCID: PMC1887850.Peer-Reviewed Original ResearchConceptsDieterle silver stainObliterative microvascular lesionsSynovial cell hyperplasiaMicroangiopathic lesionsProminent microvasculatureSynovial stromaMicrovascular injuryMicrovascular lesionsVillous hypertrophySynovial specimensCell hyperplasiaSynovial diseaseEndarteritis obliteransLymphoplasmacellular infiltrationStriking depositionNeedle biopsyStromal depositionLyme spirocheteLyme diseaseBlood vesselsPatientsSilver stainLesionsDiseaseSpirochetes
1981
Steroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment
Siegel N, Gaudio K, Krassner L, McDonald B, Anderson F, Kashgarian M. Steroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment. Kidney International 1981, 19: 454-459. PMID: 7241883, DOI: 10.1038/ki.1981.39.Peer-Reviewed Original ResearchConceptsMinimal change lesionSteroid-dependent nephrotic syndromeIncidence of relapseNephrotic syndromeMesangial proliferationSegmental glomerulosclerosisCyclophosphamide treatmentYears of followupTime of treatmentSustained remissionComplete remissionMore relapsesClinical courseHistologic typeHistopathologic typeCyclophosphamidePatientsBiopsy samplesRelapseLesionsSyndromeGlomerulosclerosisRemissionChildrenTreatment
1980
The significance of electron dense deposits in mild lupus nephritis.
Domoto D, Kashgarian M, Hayslett J, Adler M, Siegel N. The significance of electron dense deposits in mild lupus nephritis. The Yale Journal Of Biology And Medicine 1980, 53: 317-24. PMID: 7445538, PMCID: PMC2595828.Peer-Reviewed Original ResearchConceptsMild lupusSubendothelial depositsDiffuse proliferative lesionsPercent of patientsDiffuse proliferative glomerulonephritisRate of progressionElectron-dense depositsLupus nephritisSubsequent biopsyPoor prognosisProliferative glomerulonephritisDeteriorating courseMild lesionsProliferative lesionsPatientsProgressionDense depositsLupusLesionsLight microscopyWide variationGlomerulonephritisNephritisBiopsyPrognosis
1975
Minimal-lesion nephrotic syndrome with early resistance to steroid therapy
Siegel N, Gur A, Krassner L, Kashgarian M. Minimal-lesion nephrotic syndrome with early resistance to steroid therapy. The Journal Of Pediatrics 1975, 87: 377-380. PMID: 1165516, DOI: 10.1016/s0022-3476(75)80639-1.Peer-Reviewed Original ResearchConceptsMinimal lesion nephrotic syndromeNephrotic syndromeLong-term clinical courseEarly resistanceMinimal glomerular lesionsClinical courseSteroid responsivenessClinical outcomesPrompt remissionCyclophosphamide treatmentGlomerular lesionsHistopathologic lesionsPatientsRemissionCyclophosphamideSyndromeTherapyLesionsUltimate outcomeOutcomesChildrenCorticosteroidsPrednisoneRelapseSteroids
1974
Minimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis
Siegel N, Kashgarian M, Spargo B, Hayslett J. Minimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis. Nephron 1974, 13: 125-137. PMID: 4368918, DOI: 10.1159/000180385.Peer-Reviewed Original ResearchConceptsSteroid-sensitive diseaseFocal sclerotic lesionsNephrotic syndromeSclerotic lesionsMinimal change lesionCourse of diseaseMinimal glomerular changesYears of ageLipoid nephrosisSteroid resistanceClinicopathological relationshipRenal biopsyGlomerular changesFocal glomerulosclerosisUltrastructural examinationDiseaseLesionsSyndromeChildrenLight microscopyMinimal changesOnsetEarly evidenceYearsBroad spectrum
1972
CLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA
Hendler E, Kashgarian M, Hayslett J. CLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA. The Lancet 1972, 299: 458-463. PMID: 4109816, DOI: 10.1016/s0140-6736(72)90121-3.Peer-Reviewed Original ResearchConceptsRenal diseaseProliferative glomerulonephritisPathological lesionsMild proliferative glomerulonephritisUrinary tract lesionsUrinary protein excretionGroup of patientsTypes of glomerulonephritisSevere proliferative glomerulonephritisType of lesionIntercurrent infectionRenal functionRenal biopsyProtein excretionPrimary lesionClinicopathological correlationDistribution of ageCorrect diagnosisPatientsGlomerulonephritisLesionsYoung adultsDiseaseHæmorrhageUseful index
1971
Effect of azathioprine in patients with lupus glomerulonephritis
Hayslett J, Cook C, Kashgarian M, Spargo B. Effect of azathioprine in patients with lupus glomerulonephritis. Pediatric Research 1971, 5: 384-385. DOI: 10.1203/00006450-197108000-00058.Peer-Reviewed Original ResearchSevere glomerulonephritisRenal failureLupus glomerulonephritisNephrotic syndromeRenal lesionsMonths of therapyEvidence of progressionSevere renal failureMonths of treatmentEffect of azathioprinePatient's proteinuriaMembranous nephropathySevere nephritisHistological featuresIntensive treatmentMembranous changesGlomerulonephritisInexorable progressionProliferative lesionsPatientsLow dosesLesionsStriking decreaseAzathioprineMonths