2022
Podocyte VEGF-A Knockdown Induces Diffuse Glomerulosclerosis in Diabetic and in eNOS Knockout Mice
Veron D, Aggarwal PK, Li Q, Moeckel G, Kashgarian M, Tufro A. Podocyte VEGF-A Knockdown Induces Diffuse Glomerulosclerosis in Diabetic and in eNOS Knockout Mice. Frontiers In Pharmacology 2022, 12: 788886. PMID: 35280251, PMCID: PMC8906751, DOI: 10.3389/fphar.2021.788886.Peer-Reviewed Original ResearchDiabetic kidney diseaseGlomerular filtration rateDiffuse glomerulosclerosisDiabetic miceRenal failureNitric oxideMassive proteinuriaKnockout miceEndothelial nitric oxide synthase knockout miceNitric oxide synthase knockout miceNormal glomerular filtration rateAbsence of diabetesENOS knockout miceSynthase knockout miceVascular endothelial growth factorTargetable molecular mechanismsFoot process effacementEndothelial growth factorAbnormal S-nitrosylationArteriolar hyalinosisGFR lossMild proteinuriaSevere proteinuriaKidney diseaseUrinary excretion
2019
Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis
Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR. Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. JCI Insight 2019, 4: e127456. PMID: 31092735, PMCID: PMC6542610, DOI: 10.1172/jci.insight.127456.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisAcute kidney diseasePrebiopsy diagnosisKidney biopsyKidney diseaseIL-9AIN diagnosisUrine TNFInterstitial nephritisSpecific T cell subsetsAcute tubular injuryDiabetic kidney diseaseIL-9 levelsTNF-α levelsT cell subsetsAddition of biomarkersPlasma cytokinesCytokine levelsTubular injuryHighest quartileMultivariable analysisCell subsetsUrinary TNFBlood eosinophilsGlomerular disease