2003
The Distinct Contributions of Murine T Cell Receptor (TCR)γδ+ and TCRαβ+ T Cells to Different Stages of Chemically Induced Skin Cancer
Girardi M, Glusac E, Filler RB, Roberts SJ, Propperova I, Lewis J, Tigelaar RE, Hayday AC. The Distinct Contributions of Murine T Cell Receptor (TCR)γδ+ and TCRαβ+ T Cells to Different Stages of Chemically Induced Skin Cancer. Journal Of Experimental Medicine 2003, 198: 747-755. PMID: 12953094, PMCID: PMC2194182, DOI: 10.1084/jem.20021282.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinogensDisease Models, AnimalHematopoietic Stem CellsLiverMiceMice, KnockoutNeoplasm StagingPapillomaReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaSkin NeoplasmsTetradecanoylphorbol AcetateTime FactorsT-LymphocytesConceptsAlphabeta T cellsT cellsT cell receptorGammadelta cellsCell receptorProgression of papillomasResident intraepithelial lymphocytesSquamous cell carcinomaT-cell typeTwo-stage regimenMurine T cell receptorInduction of papillomasIntraepithelial lymphocytesCutaneous malignanciesCell carcinomaFVB miceHost protectionSkin cancerLow dosesCarcinomaPapillomasTumor promoterNonredundant contributionsModifier genesProgression
1995
α β and γ δ T cells can share a late common precursor
Dudley E, Girardi M, Owen M, Hayday A. α β and γ δ T cells can share a late common precursor. Current Biology 1995, 5: 659-669. PMID: 7552177, DOI: 10.1016/s0960-9822(95)00131-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCell DifferentiationDendritic CellsDNA NucleotidyltransferasesGene Rearrangement, T-LymphocyteHematopoiesisHematopoietic Stem CellsMiceMice, Inbred C57BLMolecular Sequence DataPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaStochastic ProcessesT-Lymphocyte SubsetsVDJ RecombinasesConceptsDelta geneSuccessful rearrangementLineage-determining factorsT cell receptorGene rearrangement processTCR-alpha gene rearrangementsAlpha gene rearrangementsTCR beta locusVertebrate developmentTCR delta geneAlpha betaSeparate lineagesTCR delta locusProductive rearrangementsDelta gene segmentsDelta locusBeta locusPolypeptide chainIndividual thymocytesGenesGamma geneT cell differentiationGene segmentsFragment length polymorphism techniqueCommon precursor