2020
Neurologic Characterization of Craniosynostosis: Can Direct Brain Recordings Predict Language Development?
Wu R, Nie J, Abraham P, Halligan T, Gabrick K, Peck CJ, Sawh-Martinez R, Steinbacher DM, Alperovich M, McPartland J, Persing JA. Neurologic Characterization of Craniosynostosis: Can Direct Brain Recordings Predict Language Development? Journal Of Craniofacial Surgery 2020, 32: 78-82. PMID: 32941205, DOI: 10.1097/scs.0000000000007004.Peer-Reviewed Original ResearchMeSH KeywordsBrainChildCraniosynostosesElectroencephalographyFemaleHumansInfantLanguage DevelopmentMaleSpeechConceptsNeural responsesLanguage deficitsLanguage developmentERP assessmentMetopic patientsMismatch negativity waveLarger negative amplitudesLong-term cognitionLanguage achievementCognitive outcomesMMNBrain recordingsInfant developmentBayley ScalesNegative amplitudeBSID scoresEEG testingBSIDDeficitsElectroencephalogramNeurocognitionCognitionSpeechStimuliYears of ageSpring-Assisted Strip Craniectomy Versus Cranial Vault Remodeling: Long-Term Psychological, Behavioral, and Executive Function Outcomes.
Chandler L, Allam O, Park KE, Smetona J, Gabrick KS, Wu RT, Morgan C, Park SE, Chapman LA, Couture DE, David LR, Runyan CM, Persing JA, Alperovich M. Spring-Assisted Strip Craniectomy Versus Cranial Vault Remodeling: Long-Term Psychological, Behavioral, and Executive Function Outcomes. Journal Of Craniofacial Surgery 2020, 31: 2101-2105. PMID: 32890160, DOI: 10.1097/scs.0000000000006806.Peer-Reviewed Original ResearchMeSH KeywordsCraniosynostosesCraniotomyExecutive FunctionFemaleHumansInfantMaleReference ValuesSkullSurgical EquipmentTreatment OutcomeConceptsExecutive function outcomesExecutive functioning skillsBehavior Rating InventoryBehavior Assessment SystemSocial withdrawal symptomsExecutive functionRating InventoryBASC-2Term PsychologicalNon-syndromic sagittal synostosisCohen's dSecond editionSAS groupChildrenFunction outcomesWithdrawal symptomsPsychologicalAssessment systemBehavioralSkillsParentsCaregiversInventoryExecutivesComparison of Neurocognitive Outcomes in Postoperative Adolescents with Unilateral Coronal Synostosis.
Wu RT, Gabrick KS, Singh A, Landi N, Taylor JA, Bartlett SP, Persing JA, Alperovich M. Comparison of Neurocognitive Outcomes in Postoperative Adolescents with Unilateral Coronal Synostosis. Plastic & Reconstructive Surgery 2020, 146: 614-619. PMID: 32842112, DOI: 10.1097/prs.0000000000007067.Peer-Reviewed Original ResearchConceptsPerformance intelligence quotientVisual-motor integrationVerbal intelligence quotientIntelligence quotientMean full-scale intelligence quotientMotor integrationLeft-sided patientsRight-side patientsNonsyndromic craniosynostosisLong-term functionLarge population studiesCranial vaultHigh motor coordinationMotor achievementsUnilateral coronal synostosisFull-scale intelligence quotientIndependent predictorsFemale patientsStudy cohortNeurodevelopmental assessmentAverage intelligence quotient scoresMean ageControl subjectsNeurocognitive outcomesIntelligence quotient scoresSphenoid Bone Structure and Its Influence on the Cranium in Syndromic Versus Nonsyndromic Craniosynostosis.
Lu X, Forte AJ, Park KE, Allam O, Mozaffari MA, Alperovich M, Steinbacher DM, Alonso N, Persing JA. Sphenoid Bone Structure and Its Influence on the Cranium in Syndromic Versus Nonsyndromic Craniosynostosis. Journal Of Craniofacial Surgery 2020, 32: 67-72. PMID: 32868725, DOI: 10.1097/scs.0000000000006914.Peer-Reviewed Original ResearchAssessing Facial Asymmetry in Postoperative Patients With Unilateral Coronal Craniosynostosis.
Gabrick KS, Wu RT, Singh A, Bartlett SP, Taylor JA, Persing JA, Alperovich M. Assessing Facial Asymmetry in Postoperative Patients With Unilateral Coronal Craniosynostosis. Journal Of Craniofacial Surgery 2020, 31: 1000-1005. PMID: 32176017, DOI: 10.1097/scs.0000000000006355.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildCraniosynostosesFaceFacial AsymmetryHumansImaging, Three-DimensionalPostoperative PeriodConceptsUnilateral craniosynostosisPatient-reported outcomesFacial asymmetrySurgical correctionPatient-reported outcome scoresPercent of patientsOrbital dystopiaSchool-aged patientsDysmorphic facial featuresUnilateral coronal craniosynostosisChin point deviationPostoperative patientsOutcome scoresChildren's HospitalPreoperative deformityPearson correlationPatientsAverage ageCranial base angulationRoot angulationOverall facial asymmetryNasal rootAngulationCoronal craniosynostosisHospitalCranial Fossa Development in Differing Subtypes of Crouzon Syndrome.
Lu X, Forte AJ, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Cranial Fossa Development in Differing Subtypes of Crouzon Syndrome. Journal Of Craniofacial Surgery 2020, 31: 673-677. PMID: 32049910, DOI: 10.1097/scs.0000000000006181.Peer-Reviewed Original ResearchClassification of Subtypes of Crouzon Syndrome Based on the Type of Vault Suture Synostosis.
Lu X, Sawh-Martinez R, Forte AJ, Wu R, Cabrejo R, Wilson A, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Classification of Subtypes of Crouzon Syndrome Based on the Type of Vault Suture Synostosis. Journal Of Craniofacial Surgery 2020, 31: 678-684. PMID: 32068731, DOI: 10.1097/scs.0000000000006173.Peer-Reviewed Original ResearchConceptsClass IIICrouzon syndromeClass IClass IISuture involvementSuture synostosisSimilar craniofacial characteristicsComputed tomography scanClassification of subtypesSurgical interventionMorphology of patientsAnatomic deformityTomography scanSurgical techniqueCT scanDifferent subtypesSagittal synostosisSyndromeClass IVPremature closureCraniofacial characteristicsSevere craniofacial malformationsCranial base lengthSynostosisDifferent pathologiesSMAD6 Genotype Predicts Neurodevelopment in Nonsyndromic Craniosynostosis.
Wu RT, Timberlake AT, Abraham PF, Gabrick KS, Lu X, Peck CJ, Sawh-Martinez RF, Steinbacher DM, Alperovich MA, Persing JA. SMAD6 Genotype Predicts Neurodevelopment in Nonsyndromic Craniosynostosis. Plastic & Reconstructive Surgery 2020, 145: 117e-125e. PMID: 31592950, DOI: 10.1097/prs.0000000000006319.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChildChild BehaviorChild DevelopmentChild, PreschoolCraniosynostosesCraniotomyDevelopmental DisabilitiesDouble-Blind MethodFemaleFollow-Up StudiesHumansInfantIntelligence TestsLoss of Function MutationMalePlastic Surgery ProceduresProspective StudiesSkullSmad6 ProteinTreatment Outcome
2019
What Is the Skull Structure Influence of Squamosal Suture Synostosis in Nonsyndromic and Syndromic Crouzon Craniosynostosis?
Lu X, Chen G, Forte AJ, Cabrejo R, Singh A, Kyle G, Steinbacher DM, Alperovich M, Alonso N, Persing JA. What Is the Skull Structure Influence of Squamosal Suture Synostosis in Nonsyndromic and Syndromic Crouzon Craniosynostosis? Journal Of Craniofacial Surgery 2019, 30: 1671-1675. PMID: 30950948, DOI: 10.1097/scs.0000000000005396.Peer-Reviewed Original ResearchConceptsMiddle cranial fossaAnterior cranial fossaCranial fossaPosterior cranial fossaSquamosal synostosisFossa volumeCrouzon syndromeSquamosal suture synostosisComputed tomography scanCranial volumeNonsyndromic craniosynostosis patientsVolume reductionSevere volume reductionTomography scanNormal controlsMorphologic effectsCraniosynostosis patientsFossaPremature closureSyndromic conditionsSuture synostosisSyndromic synostosisFrankfort horizontal planeSynostosisThree-dimensional cephalometryWhat is the Functional Difference Between Sagittal With Metopic and Isolated Sagittal Craniosynotosis?
Cabrejo R, Lacadie C, Chuang C, Yang J, Sun A, Brooks E, Beckett J, Eilbott J, Gabrick K, Steinbacher D, Alperovich M, Pelphrey K, Ventola P, Constable T, Persing JA. What is the Functional Difference Between Sagittal With Metopic and Isolated Sagittal Craniosynotosis? Journal Of Craniofacial Surgery 2019, 30: 968-973. PMID: 30882572, DOI: 10.1097/scs.0000000000005288.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingFunctional magnetic resonance imagingISC groupInfant patientsFunctional brain connectivityMagnetic resonance imagingResting-state functional connectivity MRI dataDTI dataWhite matter microstructureCerebrospinal fluidFMRIB Software LibraryResonance imagingSagittal synostosisSagittal craniosynostosisMetopic synostosisPatientsTensor imagingBrain connectivityMetopic craniosynostosisSMC groupFMRI imagingSignificant differencesSynostosisSagittalMRI dataNational 30-Day Outcomes for Posterior Cranial Vault Distraction
Chouairi F, Torabi SJ, Alperovich M. National 30-Day Outcomes for Posterior Cranial Vault Distraction. Journal Of Craniofacial Surgery 2019, Publish Ahead of Print: &na;. PMID: 30807468, DOI: 10.1097/scs.0000000000005285.Peer-Reviewed Original ResearchMeSH KeywordsCraniosynostosesFemaleHumansInfantMaleOsteogenesis, DistractionRetrospective StudiesSkullTreatment OutcomeConceptsPosterior vault distractionOperative timePediatric databaseNational Surgical Quality Improvement Program Pediatric databaseCalvarial volumeBlood transfusion volumeIncidence of strokeMajority of patientsSurgical site infectionPosterior cranial vault distractionNational pediatric databaseTransfusion requirementsTransfusion volumeOlder patientsPerioperative outcomesBlood transfusionPatient ageSite infectionPatient backgroundSafety profileSafe procedureRisk factorsInclusion criteriaPatient profilesPatientsUnderstanding the Learning Disabilities Linked to Sagittal Craniosynostosis
Cabrejo R, Lacadie C, Brooks E, Beckett J, Sun A, Yang J, Chuang C, Eilbott J, Duncan C, Steinbacher D, Alperovich M, Ventola P, Pelphrey K, Constable T, Persing J. Understanding the Learning Disabilities Linked to Sagittal Craniosynostosis. Journal Of Craniofacial Surgery 2019, 30: 497-502. PMID: 30676447, DOI: 10.1097/scs.0000000000005194.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderFunctional magnetic resonance imagingSagittal nonsyndromic craniosynostosisSagittal craniosynostosisDifferent neural connectionsPrimary visual cortexVisual association cortexMagnetic resonance imagingStatistical parametric mappingDeficit hyperactivity disorderBrodmann area 11Association cortexVisual cortexResonance imagingNeurocognitive deficitsNeural connectionsPatientsFMRI scansHyperactivity disorderNonsyndromic craniosynostosisParametric mappingControl adolescentsAuditory processingArea 11Craniosynostosis
2018
National Longitudinal Comparison of Patients Undergoing Surgical Management of Craniosynostosis
Wu RT, Shultz BN, Gabrick KS, Abraham PF, Cabrejo R, Persing JA, Alperovich M. National Longitudinal Comparison of Patients Undergoing Surgical Management of Craniosynostosis. Journal Of Craniofacial Surgery 2018, 29: 1755-1759. PMID: 30095569, DOI: 10.1097/scs.0000000000004775.Peer-Reviewed Original ResearchConceptsCranial vault remodelingCVR patientsLength of stayPrivate insuranceStrip craniectomyInpatient DatabaseCraniectomy patientsVault remodelingKids' Inpatient DatabaseNonsyndromic craniosynostosis patientsCraniosynostosis managementInsurancePostsurgical complicationsSurgical managementHospital chargesTreatment optionsLongitudinal comparisonHospital characteristicsSerum transfusionMedicaid patientsAccidental punctureSurgical preferenceCraniectomyPatientsMultivariate analysis
2017
Minor Suture Fusion in Syndromic Craniosynostosis
Runyan CM, Xu M D W, Alperovich M, Massie M D J, Paek G, Cohen BA, Staffenberg DA, Flores RL, Taylor JA. Minor Suture Fusion in Syndromic Craniosynostosis. Plastic & Reconstructive Surgery 2017, 140: 434e-445e. PMID: 28574949, DOI: 10.1097/prs.0000000000003586.Peer-Reviewed Original ResearchConceptsSuture synostosisCLINICAL QUESTION/LEVELSyndromic craniosynostosisSuture fusionMost patientsTomographic scanSyndromic patientsPatientsPosterior branchSkull baseCraniofacial dysostosisHead shape anomaliesSuture involvementInfantsFGFR2 mutationsSynostosisMidface abnormalitiesCraniofacial surgeonsCraniosynostosisCraniofacial dysostosis syndromesSelect groupCalvarial suturesScansShape anomaliesPatent calvarial sutures
2016
Parental Perceptions of Neurodevelopment in Toddlers Following Craniosynostosis Repair
Alperovich M, Golinko MS, Lee ZH, Runyan CM, Staffenberg DA. Parental Perceptions of Neurodevelopment in Toddlers Following Craniosynostosis Repair. Journal Of Craniofacial Surgery 2016, 27: 835-838. PMID: 27192656, DOI: 10.1097/scs.0000000000002646.Peer-Reviewed Original ResearchMeSH KeywordsChild DevelopmentCraniosynostosesDevelopmental DisabilitiesFemaleHumansInfantMaleParentsSurveys and QuestionnairesConceptsParental perceptionsNonsyndromic craniosynostosisMean scoreParents of malesCranial vault remodelingUndergo surgeryParents of childrenMean ageChild neurodevelopmentCraniosynostosis repairSurgeryVault remodelingAge groupsCraniosynostosis typeDevelopmental delayNeurodevelopmentChildren's motorLittle dataAnonymous surveySignificant differencesCranial vaultChildrenAgeMaximum scoreSchool age
2015
Is Craniosynostosis Repair Keeping Up With the Times? Results From the Largest National Survey on Craniosynostosis
Alperovich M, Vyas RM, Staffenberg DA. Is Craniosynostosis Repair Keeping Up With the Times? Results From the Largest National Survey on Craniosynostosis. Journal Of Craniofacial Surgery 2015, 26: 1909-1913. PMID: 26244471, DOI: 10.1097/scs.0000000000001300.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnti-Bacterial AgentsBlood TransfusionClinical CompetenceCraniosynostosesCritical CareDrainageHumansInfantIntraoperative ComplicationsMonitoring, IntraoperativeOperative TimePatient Care TeamPerioperative CarePlastic Surgery ProceduresPostoperative CarePractice Patterns, Physicians'Tomography, X-Ray ComputedUnited StatesConceptsPractice patternsIntensive postoperative surveillanceOverall transfusion rateLong-term antibioticsExtremes of ageCurrent practice patternsIntensive care unitShorter operative timeEvidence-based guidelinesSurgical practice patternsYears of ageNational surveyTransfusion ratePerioperative managementPostoperative surveillanceBlood transfusionOpen repairCare unitOperative timePreoperative imagingTomography scanCraniosynostosis repairSurgeon experienceExtended courseClinical practice
2014
The “Adorability” of the Ipsilateral Oblique View in Unicoronal Craniosynostosis
Vyas RM, Alperovich M, Spano M, Staffenberg DA. The “Adorability” of the Ipsilateral Oblique View in Unicoronal Craniosynostosis. Plastic & Reconstructive Surgery 2014, 134: 339e-341e. PMID: 25068367, DOI: 10.1097/prs.0000000000000329.Peer-Reviewed Original Research