2022
Comparison of the Respiratory Resistomes and Microbiota in Children Receiving Short versus Standard Course Treatment for Community-Acquired Pneumonia
Pettigrew MM, Kwon J, Gent JF, Kong Y, Wade M, Williams DJ, Creech CB, Evans S, Pan Q, Walter EB, Martin JM, Gerber JS, Newland JG, Hofto ME, Staat MA, Fowler VG, Chambers HF, Huskins WC. Comparison of the Respiratory Resistomes and Microbiota in Children Receiving Short versus Standard Course Treatment for Community-Acquired Pneumonia. MBio 2022, 13: e00195-22. PMID: 35323040, PMCID: PMC9040816, DOI: 10.1128/mbio.00195-22.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaShort-course strategyBeta-lactam therapyTreatment strategiesAntibiotic useRespiratory microbiomePediatric community-acquired pneumoniaDays of antibioticsShorter antibiotic coursesStandard-strategy groupDays of therapyStandard treatment strategyAntibiotic resistanceAdditional rationaleEffectiveness of interventionsImpact of durationAntibiotic coursesThroat swabsCourse strategyAntibiotic treatmentPediatric pneumoniaCourse treatmentLow prevalencePneumoniaAntibiotic resistance determinants
2006
Predictors for Haemophilus influenzae Colonization, Antibiotic Resistance and for Sharing an Identical Isolate Among Children Attending 16 Licensed Day-Care Centers in Michigan
Barbosa-Cesnik C, Farjo RS, Patel M, Gilsdorf J, McCoy SI, Pettigrew MM, Marrs C, Foxman B. Predictors for Haemophilus influenzae Colonization, Antibiotic Resistance and for Sharing an Identical Isolate Among Children Attending 16 Licensed Day-Care Centers in Michigan. The Pediatric Infectious Disease Journal 2006, 25: 219-223. PMID: 16511383, DOI: 10.1097/01.inf.0000202130.78540.28.Peer-Reviewed Original ResearchConceptsDay care centersH. influenzae colonizationNontypable H. influenzaeH. influenzaeOtitis mediaColonized childrenAntibiotic resistanceLicensed day care centersSame day care centerHaemophilus influenzae colonizationModifiable risk factorsRisk factor questionnaireH. influenzae isolatesNontypable Haemophilus influenzaeDay care center directorsIdentical isolatesInfluenzae isolatesPacifier useThroat swabsHygiene habitsRisk factorsTobacco smokeImportant causeHaemophilus influenzaeOverall colonization rate