Impact of antibiotics on off-target infant gut microbiota and resistance genes in cohort studies
Lebeaux RM, Madan JC, Nguyen QP, Coker MO, Dade EF, Moroishi Y, Palys TJ, Ross BD, Pettigrew MM, Morrison HG, Karagas MR, Hoen AG. Impact of antibiotics on off-target infant gut microbiota and resistance genes in cohort studies. Pediatric Research 2022, 92: 1757-1766. PMID: 35568730, PMCID: PMC9659678, DOI: 10.1038/s41390-022-02104-w.Peer-Reviewed Original ResearchConceptsAntibiotic exposureCohort studyDay careDay care attendanceInfant gut microbiotaAntibiotic resistance genesCare attendanceImpact of antibioticsAntibiotic useStool samplesGut microbiotaInfantsGut microbiomeStudy designBacteroides fragilisAntibioticsBackgroundYoung childrenNovel findingsSubsequent exposureExposureFirst yearFurther investigationBaselineResistance genesCare