Mei Zhong, PhD
Associate Research Scientist in Cell BiologyCards
About
Research
Publications
2025
Spatial dynamics of brain development and neuroinflammation
Zhang D, Rubio Rodríguez-Kirby L, Lin Y, Wang W, Song M, Wang L, Wang L, Kanatani S, Jimenez-Beristain T, Dang Y, Zhong M, Kukanja P, Bao S, Wang S, Chen X, Gao F, Wang D, Xu H, Ma C, Lou X, Liu Y, Chen J, Sestan N, Uhlén P, Kriegstein A, Zhao H, Castelo-Branco G, Fan R. Spatial dynamics of brain development and neuroinflammation. Nature 2025, 647: 213-227. PMID: 41193846, PMCID: PMC12589135, DOI: 10.1038/s41586-025-09663-y.Peer-Reviewed Original ResearchConceptsBrain developmentPostnatal day 0Chromatin accessibilitySpatial dynamicsTranscription factorsOmics informationMyelin genesDevelopmental processesProjection neuronsNeuroinflammation mouse modelMolecular programsMouse modelDisease-related alterationsTransient activationLesion coreCorpus callosumMultiplexed immunofluorescence imagesSequenceDevelopmental timepointsSpatial remodelingDay 0Mouse brainDynamics of brain developmentImmunofluorescence imagingNeuroinflammationRadiofrequency regulates the BET-mediated pathways in radial glia differentiation in human cortical development
Cakir B, Tanaka Y, Choe M, Kiral F, Kim J, Micali N, Kang Y, Dharmadhikari B, Patterson B, Yang W, Cho Y, Xiang Y, Zhong M, Lee S, Patra P, Rakic P, Park I. Radiofrequency regulates the BET-mediated pathways in radial glia differentiation in human cortical development. Cell Reports 2025, 44: 116238. PMID: 40997800, DOI: 10.1016/j.celrep.2025.116238.Peer-Reviewed Original ResearchConceptsHuman cortical organoidsHuman embryonic stem cellsExpression of human endogenous retrovirusesBrain developmentStem Cell Self-RenewalRadial glia progenitorsNeural Stem Cell Self-RenewalCell Self-RenewalHuman cortical developmentHuman endogenous retrovirusesEmbryonic stem cellsStem cell identityCortical developmentGlia progenitorsPrenatal stressSelf-RenewalStem cellsCortical organoidsNon-genetic factorsGlia differentiationDevelopmental defectsEndogenous retrovirusesBrainRadiofrequencyDelayed differentiationFeasibility of machine learning–based modeling and prediction to assess osteosarcoma outcomes
Zhao Q, Hu W, Xia Y, Dai S, Wu X, Chen J, Yuan X, Zhong T, Xi X, Wang Q. Feasibility of machine learning–based modeling and prediction to assess osteosarcoma outcomes. Scientific Reports 2025, 15: 17386. PMID: 40389469, PMCID: PMC12089500, DOI: 10.1038/s41598-025-00179-z.Peer-Reviewed Original ResearchConceptsGene signatureLow-risk score groupIncreased metastasis riskLow-risk patientsSensitive to immunotherapyUnivariate Cox regression analysisReduced immune infiltrationCox regression analysisPersonalized therapeutic strategiesAggressive bone malignancyOsteosarcoma outcomesPersonalized treatment strategiesHigh-risk scoreOverall survivalHigher mortality rateProlonged survivalMetastasis riskMulticenter cohortImmune infiltrationPoor prognosisRisk stratificationC-indexDrug sensitivityClinical managementPrognostic toolNanobody Engineered and Photosensitiser Loaded Bacterial Outer Membrane Vesicles Potentiate Antitumour Immunity and Immunotherapy
Xia P, Qu C, Xu X, Tian M, Li Z, Ma J, Hou R, Li H, Rückert F, Zhong T, Zhao L, Yuan Y, Wang J, Li Z. Nanobody Engineered and Photosensitiser Loaded Bacterial Outer Membrane Vesicles Potentiate Antitumour Immunity and Immunotherapy. Journal Of Extracellular Vesicles 2025, 14: e70069. PMID: 40240911, PMCID: PMC12003094, DOI: 10.1002/jev2.70069.Peer-Reviewed Original ResearchConceptsTumor-associated macrophagesStimulator of interferon genesOuter membrane vesiclesStimulator of interferon genes agonistsSTING activationCyclic GMP-AMP synthase (cGAS)-STING pathwayNatural stimulationBacterial outer membrane vesiclesInnate immune systemCD47 blockadeAntitumour immunityTumor immunotherapyImmunotherapeutic strategiesMetastatic tumorsTumor selectivityTumor inhibitionImmune memoryCadherin-17TumorCancer cellsCancer treatmentImmune systemInterferon genesCancerClinical applicationFunctional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches
Cakir B, Tanaka Y, Choe M, Chu P, Xiang Y, Kim K, Zhong M, Gelernter J, Zhang H, Krystal J, Park I. Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches. International Journal Of Stem Cells 2025, 18: 263-274. PMID: 40205763, PMCID: PMC12394083, DOI: 10.15283/ijsc24123.Peer-Reviewed Original ResearchHuman embryonic stem cell linesAlcohol dependenceAD-associated variantsEmbryonic stem cell linesReporter gene analysisFyn tyrosine kinase geneTyrosine kinase geneStem cell linesCRISPR-Cas9 editingAssociated with ADVulnerability to ADAD-associatedKinase geneC alleleC/T allelesMultiple polymorphismsFunctional validationGene analysisEthanol treatmentNeuropsychiatric disordersInduced neuronsAD treatmentGene editingCell linesDisease mechanisms
2024
Haplotype‐Resolved Genotyping and Association Analysis of 1,020 β‐Thalassemia Patients by Targeted Long‐Read Sequencing
Ye Y, Niu C, Mao A, Qin L, Zhan J, Chen W, Liu Z, Xie T, Zhang Q, Li J, Huang L, Meng W, Liu Y, Liao L, Cai J, Liu R, Zhang X, Zeng L, Li Y, Lin B, Li K, Hua X, Huang B, Qin H, Huang Y, Huang Z, Lao J, Qu X, Chen J, Feng X, Liu Q, Lin W, Zhou X, Liang Y, Long X, Qin J, Yan L, Zhu W, Yu L, Fan C, Tang D, Zhong T, Tan J, Ren Z, Xu X. Haplotype‐Resolved Genotyping and Association Analysis of 1,020 β‐Thalassemia Patients by Targeted Long‐Read Sequencing. Advanced Science 2024, 12: 2410992. PMID: 39737841, PMCID: PMC11884621, DOI: 10.1002/advs.202410992.Peer-Reviewed Original ResearchConceptsLong-read sequencingSingle nucleotide variantsGene clusterGlobin gene clusterT-LRSHomologous regionsStructural variantsB-thalassemia patientsTargeted long-read sequencingRare structural variantsB-thalassemiaErythroid transcription factorsHaplotype phasingNucleotide variantsAssociation analysisTranscription factorsGenetic variantsRare mutationsHaplotypesMutation spectrumExpression of fetal hemoglobinMutationsReduce transfusion dependencePatients to dateGenes/lociApplication of rapid genotyping of Warfarin individualized pharmacogenetic variants in Warfarin therapy
Huang D, Xie F, Xiao S, Cai M, Hu D, Ling B, Wang F, Lin X, Song F, Wang Q, Zhong T. Application of rapid genotyping of Warfarin individualized pharmacogenetic variants in Warfarin therapy. Scientific Reports 2024, 14: 31639. PMID: 39738187, PMCID: PMC11686395, DOI: 10.1038/s41598-024-80639-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticoagulantsCytochrome P-450 CYP2C9Cytochrome P450 Family 4FemaleGene FrequencyGenotypeGenotyping TechniquesHumansMaleMiddle AgedPharmacogeneticsPharmacogenomic VariantsPolymerase Chain ReactionPolymorphism, Single NucleotidePrecision MedicineVitamin K Epoxide ReductasesWarfarinConceptsVitamin K epoxide reductase complex 1Single-nucleotide polymorphismsAssociated with warfarin dose requirementsSingle-nucleotide polymorphism sitesDirect amplificationGenotyped single-nucleotide polymorphismsPolymorphic SNP sitesCYP2C9*2Polymerase chain reactionWarfarin dose requirementsCYP2C9*3CYP4F2*3Fluorescence melting curve analysisCytochrome P450 2C9Melting curve analysisNested polymerase chain reactionPolymorphic lociSNP sitesAccurate genotypingPharmacogenetic variantsCytochrome P450 4F2Gene sequencesPolymorphism detectionAllele frequenciesP450 2C9Guben Kechuan granule attenuates bronchial asthma by inhibiting NF-κB/STAT3 signaling pathway-mediated apoptosis
Dai C, Liu D, Qin C, Fang J, Cheng G, Xu C, Wang Q, Lu T, Guo Z, Wang J, Zhong T, Guo Q. Guben Kechuan granule attenuates bronchial asthma by inhibiting NF-κB/STAT3 signaling pathway-mediated apoptosis. Journal Of Ethnopharmacology 2024, 340: 119124. PMID: 39694430, DOI: 10.1016/j.jep.2024.119124.Peer-Reviewed Original ResearchConceptsTranscription factor STAT3Bcl-2 expressionAlveolar lavage samplesNF-kBBronchial asthmaBcl-2Caspase-3 expressionProteomic analysisProteomic resultsCaspase-3Rat model of bronchial asthmaRat modelSignaling pathwayAsthma-induced airway inflammationOxidative-stress damageApoptosisModel of bronchial asthmaInflammatory cell infiltrationTranscriptionSTAT3Oxidative-stressCytokines TNF-aOxidative stress damageAirway inflammationIL-5Characterization and functional analysis of extrachromosomal circular DNA discovered from circulating extracellular vesicles in liver failure
Qian Y, Hong X, Yu Y, Du C, Li J, Yu J, Xiao W, Chen C, Huang D, Zhong T, Li J, Xiang X, Li Z. Characterization and functional analysis of extrachromosomal circular DNA discovered from circulating extracellular vesicles in liver failure. Clinical And Translational Medicine 2024, 14: e70059. PMID: 39406484, PMCID: PMC11479749, DOI: 10.1002/ctm2.70059.Peer-Reviewed Original ResearchWhole-genome Sequencing Association Analysis of Quantitative Platelet Traits in A Large Cohort of β-thalassemia
Wang X, Zhang Q, Chen X, Huang Y, Zhang W, Liao L, Zhang X, Huang B, Huang Y, Ye Y, Song M, Lao J, Chen J, Feng X, Long X, Liu Z, Zhu W, Yu L, Fan C, Tang D, Zhong T, Fang M, Li C, Niu C, Huang L, Lin B, Hua X, Jin X, Li Z, Xu X. Whole-genome Sequencing Association Analysis of Quantitative Platelet Traits in A Large Cohort of β-thalassemia. Genomics Proteomics & Bioinformatics 2024, 23: qzae065. PMID: 39331630, PMCID: PMC12373638, DOI: 10.1093/gpbjnl/qzae065.Peer-Reviewed Original ResearchPlatelet traitsAnalysis of whole-genome sequencing dataWhole-genome sequencing dataFunctional annotation dataGenotype-phenotype association studiesRare variantsLack of genetic studiesMean platelet volumeNoncoding genomeWhole genomeSequence dataAssociation studiesMultiple genesGenetic studiesB-thalassemia patientsB-thalassemiaPhenotypic heterogeneityIntegrated analysisTraitsMissenseGenesPotential targetVariantsRV analysisGenome
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