2024
Matrix Metalloproteinase Inhibition in Rat Abdominal Aortic Aneurysm
Zaghloul M, Elizondo-Benedetto S, Arif B, Heo G, Luehmann H, Liu Y, Gropler R, Sadeghi M, Zayed M. Matrix Metalloproteinase Inhibition in Rat Abdominal Aortic Aneurysm. JVS Vascular Science 2024, 100247. DOI: 10.1016/j.jvssci.2024.100247.Peer-Reviewed Original ResearchMolecular Imaging of Collagen Turnover in Myocardial Infarction
Neishabouri A, Ghim M, Ahmad A, Kukreja G, Zhang Z, Li J, Salarian M, Toczek J, Gona K, Hedayatyanfard K, Zhang J, Huang H, Yu S, Sadeghi M. Molecular Imaging of Collagen Turnover in Myocardial Infarction. Journal Of Nuclear Cardiology 2024, 38: 101998. DOI: 10.1016/j.nuclcard.2024.101998.Peer-Reviewed Original ResearchAbstract 3015: Matrix Metalloproteinase Inhibition In Rat Abdominal Aortic Aneurysm
Zaghloul M, Elizondo-Benedetto S, Arif B, Heo G, Luehmann H, Liu Y, Gropler R, Sadeghi M, Zayed M. Abstract 3015: Matrix Metalloproteinase Inhibition In Rat Abdominal Aortic Aneurysm. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: a3015-a3015. DOI: 10.1161/atvb.44.suppl_1.3015.Peer-Reviewed Original ResearchAbdominal aortic aneurysmPostoperative day 3Rupture of abdominal aortic aneurysmsTreated ratsInhibition of matrix metalloproteinasesMatrix metalloproteinase inhibitionMatrix metalloproteinase inhibitorsMatrix metalloproteinasesAortic aneurysmRat modelAbdominal aortic aneurysm diameterUntreated groupMale Sprague-Dawley ratsAbdominal aortic aneurysm rupture rateSprague-Dawley ratsAortic diameter measurementsActive MMP-9Rate of ruptureDegradation of extracellular matrix proteinsAbdominal aortic aneurysm researchIL-17ARadiotracer uptakeUntreated ratsTNF-aIL-1BImaging Cardiac and Vascular Inflammation
Tavakoli S, Sadeghi M. Imaging Cardiac and Vascular Inflammation. 2024, 511-530. DOI: 10.1093/med/9780190095659.003.0025.Peer-Reviewed Original ResearchRisk stratification of patientsStratification of patientsPathogenesis of cardiovascular diseaseEvaluating cardiovascular pathologiesPrecision medicine toolsRisk stratificationClinical studiesEarly diagnosisInflammatory processCardiovascular diseaseMedicine toolsCardiovascular pathologyTherapeutic interventionsClinical settingImaging strategiesMolecular imagingImaging Cardiac and Vascular Inflammation
Tavakoli S, Sadeghi M. Imaging Cardiac and Vascular Inflammation. 2024, 131-133. DOI: 10.1093/med/9780197521434.003.0025.Peer-Reviewed Original ResearchRisk stratification of patientsStratification of patientsPathogenesis of cardiovascular diseaseEvaluating cardiovascular pathologiesPrecision medicine toolsRisk stratificationClinical studiesEarly diagnosisInflammatory processCardiovascular diseaseMedicine toolsCardiovascular pathologyTherapeutic interventionsClinical settingImaging strategiesMolecular imaging
2023
Psychological stress and vessel wall inflammation: Opportunity of reducing cardiovascular risk in people with HIV
Chan P, Sadeghi M. Psychological stress and vessel wall inflammation: Opportunity of reducing cardiovascular risk in people with HIV. Brain Behavior And Immunity 2023, 115: 118-119. PMID: 37820976, DOI: 10.1016/j.bbi.2023.10.007.Commentaries, Editorials and LettersMultimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve
Ahmad A, Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Raza M, Jung J, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi M. Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. Journal Of Nuclear Medicine 2023, 64: 1487-1494. PMID: 37321825, PMCID: PMC10478817, DOI: 10.2967/jnumed.123.265516.Peer-Reviewed Original ResearchConceptsF-NaF PET/CTCalcific aortic valve diseaseBicuspid aortic valvePET/CTAortic valve calcificationAortic valve diseaseAortic valveAortic stenosisValve calcificationValvular calcificationValve diseaseF-NaFSubset of miceTricuspid aortic valveDevelopment of calcificationSignificant correlationUnderwent echocardiographyMedical therapyHigh prevalencePreclinical modelsMurine modelTherapeutic interventionsAge groupsAutoradiography dataMultimodality imagingCharacteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms
Bellamkonda K, Zogg C, Nassiri N, Sadeghi M, Zhang Y, Guzman R, Chaar C. Characteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms. European Journal Of Vascular And Endovascular Surgery 2023, 65: e108. DOI: 10.1016/j.ejvs.2023.05.022.Peer-Reviewed Original ResearchRadiotracers to address unmet clinical needs in cardiovascular imaging, part 2: inflammation, fibrosis, thrombosis, calcification, and amyloidosis imaging
Stendahl J, Kwan J, Pucar D, Sadeghi M. Radiotracers to address unmet clinical needs in cardiovascular imaging, part 2: inflammation, fibrosis, thrombosis, calcification, and amyloidosis imaging. Chinese Journal Of Nuclear Medicine And Molecular Imaging 2023, 43: 187-192. DOI: 10.3760/cma.j.cn321828-20221103-00333.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRadiotracers to address unmet clinical needs in cardiovascular imaging, part 1: technical considerations and perfusion and neuronal imaging
Stendahl J, Kwan J, Pucar D, Sadeghi M. Radiotracers to address unmet clinical needs in cardiovascular imaging, part 1: technical considerations and perfusion and neuronal imaging. Chinese Journal Of Nuclear Medicine And Molecular Imaging 2023, 43: 122-128. DOI: 10.3760/cma.j.cn321828-20221009-00301.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCharacteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms
Bellamkonda K, Zogg C, Nassiri N, Sadeghi M, Zhang Y, Guzman R, Ochoa Chaar C. Characteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms. Journal Of Vascular Surgery 2023, 77: 1649-1657. PMID: 36796595, DOI: 10.1016/j.jvs.2023.02.003.Peer-Reviewed Original ResearchConceptsEndovascular aneurysm repairAbdominal aortic aneurysmRAAA casesRAAA groupElective repairAneurysm repairAortic aneurysmMyocardial infarctionVascular Quality Initiative databaseLower body mass indexSmall abdominal aortic aneurysmsMean aneurysm diameterVascular Surgery guidelinesLong-term mortalityOutcomes of patientsPerioperative myocardial infarctionOpen AAA repairBody mass indexLong-term outcomesOperative thresholdAfrican AmericansInfrarenal aneurysmsTotal morbidityAAA repairPatient characteristicsHomeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity
Salarian M, Ghim M, Toczek J, Han J, Weiss D, Spronck B, Ramachandra A, Jung J, Kukreja G, Zhang J, Lakheram D, Kim S, Humphrey J, Sadeghi M. Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity. Circulation Research 2023, 132: 432-448. PMID: 36691905, PMCID: PMC9930896, DOI: 10.1161/circresaha.122.322096.Peer-Reviewed Original ResearchConceptsMMP-12 deficiencyAdverse aortic remodelingAbdominal aortic aneurysmAng IIAortic remodelingAortic aneurysmMMP-12Complement component 3 levelsNeutrophil extracellular traps markersAbdominal aortic aneurysm ruptureAortic aneurysm ruptureElastic lamina degradationPlasma complement componentsAortic ruptureC3 levelsComplement depositionPlasma C5aMore neutrophilsVascular remodelingAneurysm ruptureNeutrophil elastaseAortic integrityMatrix metalloproteinaseComplement inhibitorsNETosis pathwayPositron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm
Toczek J, Gona K, Liu Y, Ahmad A, Ghim M, Ojha D, Kukreja G, Salarian M, Luehmann H, Heo G, Guzman R, Chaar C, Tellides G, Hassab A, Ye Y, Shoghi K, Zayed M, Gropler R, Sadeghi M. Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2023, 16: e014615. PMID: 36649454, PMCID: PMC9858355, DOI: 10.1161/circimaging.122.014615.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmHuman aortic tissueMMP activityAortic tissueAortic aneurysmMMP inhibitorsMurine modelMatrix metalloproteinasesPositron emission tomography/Toxicology studiesAortic MMP activityPositron emission tomography radioligandAngiotensin II infusionEmission tomography/Murine abdominal aortic aneurysmsBroad-spectrum MMP inhibitorMatrix metalloproteinase activityPositron emission tomography (PET) tracerPositron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyEmission tomography tracerII infusionRisk stratificationTomography/
2022
Beyond perfusion imaging
Sadeghi MM. Beyond perfusion imaging. Journal Of Nuclear Cardiology 2022, 29: 1485-1486. PMID: 35790690, DOI: 10.1007/s12350-022-03050-0.Peer-Reviewed Original ResearchRadiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging
Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging. Journal Of Nuclear Medicine 2022, 63: 986-994. PMID: 35772956, PMCID: PMC9258561, DOI: 10.2967/jnumed.121.263507.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiovascular imagingDevice-related thrombusDetection of thrombusUnmet diagnostic needsFibroblast activation proteinCardiovascular fibrosisCardiovascular inflammationRisk stratificationDiagnostic needsCardiovascular calcificationMyocardial infarctionInflammatory responseUnmet ClinicalNew radiotracersCardiovascular medicinePersonalized therapyFibrosisActivation proteinSPECT imagingAmyloidosisCalcificationThrombosisInflammationRadiotracer developmentThrombusDeletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice
Spronck B, Ramachandra AB, Moriyama L, Toczek J, Han J, Sadeghi MM, Humphrey JD. Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice. Journal Of Biomechanics 2022, 141: 111179. PMID: 35759974, PMCID: PMC9585962, DOI: 10.1016/j.jbiomech.2022.111179.Peer-Reviewed Original ResearchConceptsPulse wave velocityAortic phenotypeYoung miceAortic agingMMP-12Matrix metalloproteinasesMMP-12-deficient miceOld adult miceMatrix metalloproteinase-12Biomechanical propertiesAbdominal aortaArterial agingDeficient miceEnd organsBlood flowAdult miceCentral arteriesPercent changeMetalloproteinase-12MiceArterial wallAortaYoung adultsMatrix turnoverStrong proteolytic activityTargeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression
Zhang X, Rotllan N, Canfrán-Duque A, Sun J, Toczek J, Moshnikova A, Malik S, Price NL, Araldi E, Zhong W, Sadeghi MM, Andreev OA, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C. Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression. Circulation Research 2022, 131: 77-90. PMID: 35534923, PMCID: PMC9640270, DOI: 10.1161/circresaha.121.320296.Peer-Reviewed Original ResearchConceptsMiR-33Gene expressionNature of miRNAsSingle-cell RNA sequencing analysisSingle-cell RNA transcriptomicsAnti-miRNA technologiesRNA sequencing analysisExpression of miRNAsRNA transcriptomicsNew therapeutic opportunitiesEntire pathwayMiRNA therapeuticsAtherosclerotic plaque macrophagesHuman diseasesMiRNAsSequencing analysisSpecific tissuesMetabolic tissuesTargeted suppressionMiR-33 inhibitionProtective miRNAsNumerous diseasesPharmacological inhibitionLipid accumulationTarget effectsRadiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging.
Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging. Journal Of Nuclear Medicine 2022, 63: 649-658. PMID: 35487563, DOI: 10.2967/jnumed.121.263506.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUnmet diagnostic needsCardiovascular medicineNeuronal imagingImaging of inflammationHeart failureValvular diseaseTechnical considerationsDiagnostic needsCardiac amyloidosisUnmet ClinicalNew radiotracersCardiovascular imagingPersonalized therapyPerfusion tracerPET perfusion tracerThrombosisRadiotracer developmentRadiotracerPerfusionF-FlurpiridazImagingReviewMedicineKey technical considerationsMolecular characterizationDifferential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification
Jung JJ, Ahmad AA, Rajendran S, Wei L, Zhang J, Toczek J, Nie L, Kukreja G, Salarian M, Gona K, Ghim M, Chakraborty R, Martin KA, Tellides G, Heistad D, Sadeghi MM. Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification. JACC Basic To Translational Science 2022, 7: 333-345. PMID: 35540096, PMCID: PMC9079798, DOI: 10.1016/j.jacbts.2021.12.006.Peer-Reviewed Original ResearchBicuspid aortic valveCalcific aortic valve diseaseAortic valve calcificationValve calcificationHuman Calcific Aortic Valve DiseaseAortic valve diseaseValve diseaseAortic valveCAVD progressionTherapeutic targetBone morphogenic proteinMorphogenic proteinMiceCalcificationDCBLD2StenosisExpressionLittermatesDiseaseBMP signalingProgression
2021
ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3
Coppo R, Orso F, Virga F, Dalmasso A, Baruffaldi D, Nie L, Clapero F, Dettori D, Quirico L, Grassi E, Defilippi P, Provero P, Valdembri D, Serini G, Sadeghi MM, Mazzone M, Taverna D. ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3. Cancer Letters 2021, 510: 13-23. PMID: 33862151, PMCID: PMC8581997, DOI: 10.1016/j.canlet.2021.04.005.Peer-Reviewed Original Research