2016
Matrix Metalloproteinase–Targeted Imaging of Lung Inflammation and Remodeling
Golestani R, Razavian M, Ye Y, Zhang J, Jung JJ, Toczek J, Gona K, Kim HY, Elias JA, Lee CG, Homer RJ, Sadeghi MM. Matrix Metalloproteinase–Targeted Imaging of Lung Inflammation and Remodeling. Journal Of Nuclear Medicine 2016, 58: 138-143. PMID: 27469361, PMCID: PMC5209638, DOI: 10.2967/jnumed.116.176198.Peer-Reviewed Original ResearchConceptsSmall-animal SPECT/CTSPECT/CTMatrix metalloproteinasesTg lungsLung inflammationTg miceIL-13 transgenic miceReal-time reverse transcription-polymerase chain reactionReverse transcription-polymerase chain reactionWild-type littermatesTranscription-polymerase chain reactionWild-type animalsMolecular imagingPulmonary inflammationPulmonary diseaseCD68 expressionLung diseasePolymerase chain reactionPulmonary pathologyEarly diagnosisInflammationMMP-13Transgenic miceMatrix metalloproteinaseMMP-12
2011
Atherosclerosis Plaque Heterogeneity and Response to Therapy Detected by In Vivo Molecular Imaging of Matrix Metalloproteinase Activation
Razavian M, Tavakoli S, Zhang J, Nie L, Dobrucki LW, Sinusas AJ, Azure M, Robinson S, Sadeghi MM. Atherosclerosis Plaque Heterogeneity and Response to Therapy Detected by In Vivo Molecular Imaging of Matrix Metalloproteinase Activation. Journal Of Nuclear Medicine 2011, 52: 1795-1802. PMID: 21969358, PMCID: PMC3235922, DOI: 10.2967/jnumed.111.092379.Peer-Reviewed Original ResearchConceptsHigh-fat dietSPECT/CTTracer uptakeMMP activationNormal chowMatrix metalloproteinasesApolipoprotein-deficient miceOil Red O stainingDevelopment of atherosclerosisMatrix metalloproteinase activationRed O stainingAtherosclerotic mouse aortasOil Red OHFD withdrawalMolecular imagingAreas of discordanceDietary modificationMacrophage infiltrationPlaque presenceMacrophage contentPlaque areaPlaque biologyAtherosclerotic plaquesMMP expressionMetalloproteinase activation
2010
Molecular Imaging of Matrix Metalloproteinase Activation to Predict Murine Aneurysm Expansion In Vivo
Razavian M, Zhang J, Nie L, Tavakoli S, Razavian N, Dobrucki LW, Sinusas AJ, Edwards DS, Azure M, Sadeghi MM. Molecular Imaging of Matrix Metalloproteinase Activation to Predict Murine Aneurysm Expansion In Vivo. Journal Of Nuclear Medicine 2010, 51: 1107-1115. PMID: 20554725, PMCID: PMC2908304, DOI: 10.2967/jnumed.110.075259.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins EArteriovenous FistulaAutoradiographyCarotid ArteriesCatalysisDisease ProgressionEnzyme ActivationImmunohistochemistryIndicators and ReagentsMatrix MetalloproteinasesMiceMice, KnockoutRadiopharmaceuticalsReverse Transcriptase Polymerase Chain ReactionSubstrate SpecificityTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonConceptsMatrix metalloproteinase activationMMP activationAneurysm inductionMetalloproteinase activationSPECT/CTCurrent imaging modalitiesPathogenesis of aneurysmsSpecific MMP inhibitorsGroups of animalsMMP tracerMolecular imagingArterial aneurysmsAneurysm expansionFocal uptakeDeficient miceCarotid aneurysmsCarotid arteryApolipoprotein ETracer uptakeAneurysmsMajor causeMMP inhibitorsVessel areaImaging modalitiesWk