2015
Multimodality and Molecular Imaging of Matrix Metalloproteinase Activation in Calcific Aortic Valve Disease
Jung JJ, Razavian M, Challa AA, Nie L, Golestani R, Zhang J, Ye Y, Russell KS, Robinson SP, Heistad DD, Sadeghi MM. Multimodality and Molecular Imaging of Matrix Metalloproteinase Activation in Calcific Aortic Valve Disease. Journal Of Nuclear Medicine 2015, 56: 933-938. PMID: 25908827, PMCID: PMC4454445, DOI: 10.2967/jnumed.114.152355.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortic ValveAortic Valve StenosisApolipoproteins EBicuspid Aortic Valve DiseaseCalcinosisDiet, High-FatEchocardiographyHeart Defects, CongenitalHeart Valve DiseasesHumansMatrix MetalloproteinasesMiceMice, TransgenicMolecular ImagingMultimodal ImagingTechnetiumTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsCalcific aortic valve diseaseAortic valve diseaseMatrix metalloproteinasesWestern dietValve diseaseValvular inflammationMMP activityDevelopment of CAVDMedical therapeutic interventionsAortic valve areaSPECT/CT imagesWild-type miceMatrix metalloproteinase activationAortic stenosisMolecular imagingValvular calcificationControl miceCD68 expressionValve areaWD miceDeficient miceCommon causeApolipoprotein ECD68 stainingMurine model
2011
Atherosclerosis Plaque Heterogeneity and Response to Therapy Detected by In Vivo Molecular Imaging of Matrix Metalloproteinase Activation
Razavian M, Tavakoli S, Zhang J, Nie L, Dobrucki LW, Sinusas AJ, Azure M, Robinson S, Sadeghi MM. Atherosclerosis Plaque Heterogeneity and Response to Therapy Detected by In Vivo Molecular Imaging of Matrix Metalloproteinase Activation. Journal Of Nuclear Medicine 2011, 52: 1795-1802. PMID: 21969358, PMCID: PMC3235922, DOI: 10.2967/jnumed.111.092379.Peer-Reviewed Original ResearchConceptsHigh-fat dietSPECT/CTTracer uptakeMMP activationNormal chowMatrix metalloproteinasesApolipoprotein-deficient miceOil Red O stainingDevelopment of atherosclerosisMatrix metalloproteinase activationRed O stainingAtherosclerotic mouse aortasOil Red OHFD withdrawalMolecular imagingAreas of discordanceDietary modificationMacrophage infiltrationPlaque presenceMacrophage contentPlaque areaPlaque biologyAtherosclerotic plaquesMMP expressionMetalloproteinase activation
2010
Matrix Metalloproteinase Activation Predicts Amelioration of Remodeling After Dietary Modification in Injured Arteries
Tavakoli S, Razavian M, Zhang J, Nie L, Marfatia R, Dobrucki LW, Sinusas AJ, Robinson S, Edwards DS, Sadeghi MM. Matrix Metalloproteinase Activation Predicts Amelioration of Remodeling After Dietary Modification in Injured Arteries. Arteriosclerosis Thrombosis And Vascular Biology 2010, 31: 102-109. PMID: 20947820, PMCID: PMC3005135, DOI: 10.1161/atvbaha.110.216036.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins ECarotid Artery InjuriesCarotid Artery, CommonDietary FatsDisease Models, AnimalEnzyme ActivationFemaleInflammationMatrix Metalloproteinase InhibitorsMatrix MetalloproteinasesMiceMice, KnockoutMolecular ImagingProtease InhibitorsTime FactorsTomography, Emission-Computed, Single-PhotonX-Ray MicrotomographyConceptsHigh-fat dietMatrix metalloproteinase activationDietary modificationGroups of animalsMMP activationVascular remodelingMetalloproteinase activationCarotid artery wire injuryMonocyte/macrophage infiltrationMicro-single photon emissionCarotid neointima formationSingle photon emissionMacrophage infiltrationVascular injuryWire injuryNeointimal areaCarotid arteryNeointima formationInjured arteriesHistological analysisSurgeryWeeksNoninvasive imagingDietArteryMolecular Imaging of Matrix Metalloproteinase Activation to Predict Murine Aneurysm Expansion In Vivo
Razavian M, Zhang J, Nie L, Tavakoli S, Razavian N, Dobrucki LW, Sinusas AJ, Edwards DS, Azure M, Sadeghi MM. Molecular Imaging of Matrix Metalloproteinase Activation to Predict Murine Aneurysm Expansion In Vivo. Journal Of Nuclear Medicine 2010, 51: 1107-1115. PMID: 20554725, PMCID: PMC2908304, DOI: 10.2967/jnumed.110.075259.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins EArteriovenous FistulaAutoradiographyCarotid ArteriesCatalysisDisease ProgressionEnzyme ActivationImmunohistochemistryIndicators and ReagentsMatrix MetalloproteinasesMiceMice, KnockoutRadiopharmaceuticalsReverse Transcriptase Polymerase Chain ReactionSubstrate SpecificityTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonConceptsMatrix metalloproteinase activationMMP activationAneurysm inductionMetalloproteinase activationSPECT/CTCurrent imaging modalitiesPathogenesis of aneurysmsSpecific MMP inhibitorsGroups of animalsMMP tracerMolecular imagingArterial aneurysmsAneurysm expansionFocal uptakeDeficient miceCarotid aneurysmsCarotid arteryApolipoprotein ETracer uptakeAneurysmsMajor causeMMP inhibitorsVessel areaImaging modalitiesWk
2008
Molecular Imaging of Activated Matrix Metalloproteinases in Vascular Remodeling
Zhang J, Nie L, Razavian M, Ahmed M, Dobrucki LW, Asadi A, Edwards DS, Azure M, Sinusas AJ, Sadeghi MM. Molecular Imaging of Activated Matrix Metalloproteinases in Vascular Remodeling. Circulation 2008, 118: 1953-1960. PMID: 18936327, PMCID: PMC2637824, DOI: 10.1161/circulationaha.108.789743.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAnimalsApolipoproteins EAutoradiographyCarotid Artery InjuriesCarotid Artery, CommonDisease Models, AnimalFemaleFluorescent Antibody TechniqueIndiumMatrix Metalloproteinase 2Matrix Metalloproteinase 9MiceMice, Mutant StrainsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonConceptsVascular remodelingCarotid arteryCommon carotid artery injuryInjury-induced vascular remodelingCarotid wire injuryCarotid artery injuryMicroSPECT/CTMatrix metalloproteinase activationVessel wall areaArtery injuryCarotid injurySham surgerySignificant hyperplasiaContralateral arteryWire injuryFocal uptakeHyperplastic processesMicroSPECT imagingQuantitative autoradiographyTracer uptakeMetalloproteinase activationMMP activityArteryInjuryMatrix metalloproteinases