2022
Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice
Spronck B, Ramachandra AB, Moriyama L, Toczek J, Han J, Sadeghi MM, Humphrey JD. Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice. Journal Of Biomechanics 2022, 141: 111179. PMID: 35759974, PMCID: PMC9585962, DOI: 10.1016/j.jbiomech.2022.111179.Peer-Reviewed Original ResearchConceptsPulse wave velocityAortic phenotypeYoung miceAortic agingMMP-12Matrix metalloproteinasesMMP-12-deficient miceOld adult miceMatrix metalloproteinase-12Biomechanical propertiesAbdominal aortaArterial agingDeficient miceEnd organsBlood flowAdult miceCentral arteriesPercent changeMetalloproteinase-12MiceArterial wallAortaYoung adultsMatrix turnoverStrong proteolytic activity
2017
Multi-modality molecular imaging of aortic aneurysms
Malm BJ, Sadeghi MM. Multi-modality molecular imaging of aortic aneurysms. Journal Of Nuclear Cardiology 2017, 24: 1239-1245. PMID: 28447279, PMCID: PMC7720418, DOI: 10.1007/s12350-017-0883-2.BooksConceptsAortic aneurysmMulti-modality molecular imagingMolecular imagingSignificant morbidityAbdominal aortaAneurysm formationAneurysm sizeLower riskAneurysm pathogenesisAneurysmsPotential future roleImaging modalitiesComplicationsDiagnosisImagingMorbidityThrombosisPatientsAortaCurrent gapsFuture rolePathogenesisThoracicMortalityEpidemiology