2013
Anr and Its Activation by PlcH Activity in Pseudomonas aeruginosa Host Colonization and Virulence
Jackson A, Gross M, Daniels E, Hampton T, Hammond J, Vallet-Gely I, Dove S, Stanton B, Hogan D. Anr and Its Activation by PlcH Activity in Pseudomonas aeruginosa Host Colonization and Virulence. Journal Of Bacteriology 2013, 195: 3093-3104. PMID: 23667230, PMCID: PMC3697539, DOI: 10.1128/jb.02169-12.Peer-Reviewed Original ResearchConceptsANR activityGlycine betainePlcH activityBiofilm formationHemolytic phospholipase CEnhanced biofilm formationGlucose-containing mediumP. aeruginosa PAO1Host colonizationLow oxygen tensionWild typeAbiotic surfacesMicroarray analysisAeruginosa PAO1Epithelial cell monolayersAbundant lipidsLines of evidenceAddition of cholinePhospholipase CCell membraneVirulenceBacterial metabolismProtein levelsMutantsRespiratory activity
2012
Prevalence of Streptococci and Increased Polymicrobial Diversity Associated with Cystic Fibrosis Patient Stability
Filkins L, Hampton T, Gifford A, Gross M, Hogan D, Sogin M, Morrison H, Paster B, O'Toole G. Prevalence of Streptococci and Increased Polymicrobial Diversity Associated with Cystic Fibrosis Patient Stability. Journal Of Bacteriology 2012, 194: 4709-4717. PMID: 22753064, PMCID: PMC3415522, DOI: 10.1128/jb.00566-12.Peer-Reviewed Original ResearchConceptsDiverse microbial communitiesHigher bacterial diversityCystic fibrosis lung environmentQuantitative PCRGenomic DNA samplesCystic fibrosis patientsMicrobial communitiesRRNA geneBacterial communitiesBacterial diversityOverall diversityTaxonomic profilesGroup speciesMicroarray analysisDominant organismsPseudomonas aeruginosaPatient stabilityPredominant generaFibrosis patientsSpeciesHypervariable regionSpecies of StreptococcusCurrent dogmaStable lung diseaseDiversity