2009
Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2‐gonadotropin‐releasing hormone neurons via a direct postsynaptic mechanism
Wu M, Dumalska I, Morozova E, Van Den Pol AN, Alreja M. Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2‐gonadotropin‐releasing hormone neurons via a direct postsynaptic mechanism. The Journal Of Physiology 2009, 587: 1401-1411. PMID: 19204051, PMCID: PMC2678216, DOI: 10.1113/jphysiol.2008.166447.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsFemaleGamma-Aminobutyric AcidGlutamate DecarboxylaseGlutamic AcidGlycoproteinsGonadotropin-Releasing HormoneGreen Fluorescent ProteinsImmunohistochemistryMaleMiceMice, TransgenicNeural InhibitionNeuronsNeuropeptidesPatch-Clamp TechniquesPotassiumProsencephalonRecombinant Fusion ProteinsSynaptic PotentialsSynaptic TransmissionTime FactorsVesicular Glutamate Transport Protein 2ConceptsGnIH/RFRPGonadotropin-inhibitory hormoneHormone neuronsGnRH neuronsGonadotropin releaseRFRP-3Inhibitory hormoneGonadotropin-releasing hormone (GnRH) neuronsAvian gonadotropin-inhibitory hormoneDirect postsynaptic mechanismGAD67-GFP miceVesicular glutamate transportersTarget brain regionsGABAergic neuronsGlutamate releasePostsynaptic mechanismsAnterior pituitaryBrain slicesMedian eminenceGlutamate transportersReproductive functionBrain regionsInhibitory actionElectrophysiological recordingsNeurons
2004
Histamine innervation and activation of septohippocampal GABAergic neurones: involvement of local ACh release
Xu C, Michelsen KA, Wu M, Morozova E, Panula P, Alreja M. Histamine innervation and activation of septohippocampal GABAergic neurones: involvement of local ACh release. The Journal Of Physiology 2004, 561: 657-670. PMID: 15486020, PMCID: PMC1665378, DOI: 10.1113/jphysiol.2004.071712.Peer-Reviewed Original ResearchConceptsLocal ACh releaseACh releaseGABAergic neuronesCholinergic neuronesSeptohippocampal cholinergicMedial septum/diagonal bandHistamine-induced activationGABAergic cell typesReceptor-selective antagonistHippocampal theta rhythmIndirect mechanismsConcentration-dependent mannerAtropine methylbromideHippocampal arousalGABAergic functionHistaminergic systemTuberomammillary nucleusCholinergic systemReceptor subtypesDiagonal bandHistamine effectSelective antagonistAlzheimer's diseaseGABAergic nucleusNeurodegenerative disorders