2008
Excitatory Effects of the Puberty-Initiating Peptide Kisspeptin and Group I Metabotropic Glutamate Receptor Agonists Differentiate Two Distinct Subpopulations of Gonadotropin-Releasing Hormone Neurons
Dumalska I, Wu M, Morozova E, Liu R, van den Pol A, Alreja M. Excitatory Effects of the Puberty-Initiating Peptide Kisspeptin and Group I Metabotropic Glutamate Receptor Agonists Differentiate Two Distinct Subpopulations of Gonadotropin-Releasing Hormone Neurons. Journal Of Neuroscience 2008, 28: 8003-8013. PMID: 18685025, PMCID: PMC2597556, DOI: 10.1523/jneurosci.1225-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBarium CompoundsCapillariesChloridesDiagonal Band of BrocaDrug ResistanceElectrophysiologyFemaleGonadotropin-Releasing HormoneGreen Fluorescent ProteinsIn Vitro TechniquesMaleMedian EminenceMethoxyhydroxyphenylglycolMiceMice, TransgenicNeuronsPotassium ChannelsRatsRats, Sprague-DawleyReceptors, Metabotropic GlutamateRNA, MessengerSynapsesTumor Suppressor ProteinsVesicular Glutamate Transport Protein 2ConceptsMetabotropic glutamate receptor agonistGlutamate receptor agonistsGroup I metabotropic glutamate receptor agonistReceptor agonistGnRH neuronsGonadotropin-Releasing Hormone NeuronsG protein-coupled receptor GPR54Vesicular glutamate transporter 2GnRH-GFP miceRetrograde labeling techniqueGlutamate transporter 2Gonadotropin-releasing hormoneDistinct subpopulationsOnset of pubertyPostpubertal miceHormone neuronsGnRH cellsExcitatory effectsCentral releaseHypogonadotropic hypogonadismPeptide kisspeptinReceptor GPR54Brain slicesNormal pubertyKisspeptin
2007
Neurokinins robustly activate the majority of septohippocampal cholinergic neurons
Morozova E, Wu M, Dumalska I, Alreja M. Neurokinins robustly activate the majority of septohippocampal cholinergic neurons. European Journal Of Neuroscience 2007, 27: 114-122. PMID: 18184316, DOI: 10.1111/j.1460-9568.2007.05993.x.Peer-Reviewed Original ResearchConceptsSeptohippocampal cholinergic neuronsHippocampal acetylcholine releaseCholinergic neuronsNK3 receptorsHemokinin-1Acetylcholine releaseNK2 receptorsElectrophysiological effectsRat brain slice preparationWhole-cell patch-clamp recordingsMedial septum/diagonal bandDiagonal band neuronsNK3 receptor agonistPost-synaptic mechanismsStress-related affective disordersBrain slice preparationPatch-clamp recordingsEffect of NKCholinergic cellsNK receptorsReceptor agonistSlice preparationDiagonal bandNeurokinin receptorsBrain neurons
2006
Muscarine activates the sodium–calcium exchanger via M3 receptors in basal forebrain neurons
Xu C, Wu M, Morozova E, Alreja M. Muscarine activates the sodium–calcium exchanger via M3 receptors in basal forebrain neurons. European Journal Of Neuroscience 2006, 24: 2309-2313. PMID: 17074051, DOI: 10.1111/j.1460-9568.2006.05118.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasal GangliaBiotransformationDiagonal Band of BrocaDiphenylacetic AcidsElectrophysiologyIn Vitro TechniquesIon ChannelsIonsLithium ChlorideMaleMuscarineMuscarinic AgonistsPatch-Clamp TechniquesPiperidinesProsencephalonRatsRats, Sprague-DawleyReceptor, Muscarinic M3Sodium-Calcium ExchangerThioureaConceptsMuscarinic activationWhole-cell patch-clamp recording techniqueMedial septum/diagonal bandPatch-clamp recording techniquesSeptohippocampal GABAergic neuronsBasal forebrain neuronsMuscarinic cholinergic mechanismsRat brain slicesHippocampus-dependent learningHippocampal theta rhythmSodium-calcium exchangerIntraseptal carbacholMSDB neuronsCholinergic neuronsExcitatory actionGABAergic neuronsCholinergic mechanismsKB-R7943M3 receptorsForebrain neuronsDiagonal bandPrimary involvementBrain slicesHippocampal functionPotent modulator