2023
Physician’s comfort level with observing ductal carcinoma in situ of the breast: a survey of breast specialists at accredited breast centers in the United States
Poli E, Chang C, Bleicher R, Moran M, Dietz J, Sarantou T, Kurtzman S, Yao K. Physician’s comfort level with observing ductal carcinoma in situ of the breast: a survey of breast specialists at accredited breast centers in the United States. Annals Of Breast Surgery 2023, 0: 0-0. DOI: 10.21037/abs-22-1.Peer-Reviewed Original Research
2016
Society of Surgical Oncology–American Society for Radiation Oncology–American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma In Situ
Morrow M, Van Zee KJ, Solin LJ, Houssami N, Chavez-MacGregor M, Harris JR, Horton J, Hwang S, Johnson PL, Marinovich ML, Schnitt SJ, Wapnir I, Moran MS. Society of Surgical Oncology–American Society for Radiation Oncology–American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma In Situ. Journal Of Clinical Oncology 2016, 34: 4040-4046. PMID: 27528719, PMCID: PMC5477830, DOI: 10.1200/jco.2016.68.3573.Peer-Reviewed Original ResearchConceptsIpsilateral breast tumor recurrenceWhole breast irradiationRisk of IBTRNegative marginsDuctal carcinomaRate of IBTRSurgical Oncology–American SocietyMargin widthMultidisciplinary consensus panelBreast tumor recurrenceBreast conserving surgeryBreast-conserving surgeryNegative margin widthOptimal negative margin widthRe-excision ratesHealth care costsFurther surgeryPositive marginsBreast irradiationConsensus guidelinesCosmetic outcomeTumor recurrenceClear marginsConsensus panelBackground ControversyRadiation Boost for Ductal Carcinoma In Situ After Whole-Breast Radiation Therapy (WBRT) Improves Local Control: Analysis From 10 Pooled Academic Institutions
Moran M, Zhao Y, Ma S, Kirova Y, Fourquet A, Chen P, Hoffman K, Hunt K, Wong J, Halasz L, Freedman G, Prosnitz R, Yassa M, Nguyen D, Hijal T, Haffty B, Wai E, Truong P. Radiation Boost for Ductal Carcinoma In Situ After Whole-Breast Radiation Therapy (WBRT) Improves Local Control: Analysis From 10 Pooled Academic Institutions. International Journal Of Radiation Oncology • Biology • Physics 2016, 96: s144. DOI: 10.1016/j.ijrobp.2016.06.349.Peer-Reviewed Original Research
2015
Assessment of Practice Patterns Following Publication of the SSO–ASTRO Consensus Guideline on Margins for Breast-Conserving Therapy in Stage I and II Invasive Breast Cancer
DeSnyder SM, Hunt KK, Smith BD, Moran MS, Klimberg S, Lucci A. Assessment of Practice Patterns Following Publication of the SSO–ASTRO Consensus Guideline on Margins for Breast-Conserving Therapy in Stage I and II Invasive Breast Cancer. Annals Of Surgical Oncology 2015, 22: 3250-3256. PMID: 26202554, PMCID: PMC4696114, DOI: 10.1245/s10434-015-4666-1.Peer-Reviewed Original ResearchConceptsConsensus guidelinesInked marginInvasive breast cancerBreast-Conserving TherapyTriple-negative tumorsCurrent clinical practiceIndividual clinical judgmentDuctal carcinomaBreast surgeonsPractice patternsBreast cancerStage IClinical practiceClinical judgmentTumorsMethodsA surveyAdequate marginsPractice typeMultiple fociAmerican SocietySurgeonsGuidelinesMultiple marginsCarcinomaTherapy
2012
Multi-Institutional Experience of Ductal Carcinoma In Situ in Black vs White Patients Treated With Breast-Conserving Surgery and Whole Breast Radiation Therapy
Nelson C, Bai H, Neboori H, Takita C, Motwani S, Wright JL, Hobeika G, Haffty BG, Jones T, Goyal S, Moran MS. Multi-Institutional Experience of Ductal Carcinoma In Situ in Black vs White Patients Treated With Breast-Conserving Surgery and Whole Breast Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2012, 84: e279-e283. PMID: 22672752, DOI: 10.1016/j.ijrobp.2012.03.068.Peer-Reviewed Original ResearchConceptsWhole breast radiation therapyLocal relapse-free survivalRelapse-free survivalBreast-conserving surgeryBreast radiation therapyDCIS patientsRadiation therapyBreast conservationBlack patientsDuctal carcinomaRacial disparitiesUniversity-based cancer centerSignificant overall survival differenceFunction of raceAdjuvant radiation therapyBreast conserving surgeryOverall survival differenceEstrogen receptor statusMulti-institutional cohortMulti-institutional experiencePositive margin rateSignificant racial differencesTreatment delivery parametersPaucity of dataHormonal therapy
2011
ACR Appropriateness Criteria® Ductal Carcinoma in Situ
Moran MS, Bai HX, Harris EE, Arthur DW, Bailey L, Bellon JR, Carey L, Goyal S, Halyard MY, Horst KC, MacDonald SM, Haffty BG. ACR Appropriateness Criteria® Ductal Carcinoma in Situ. The Breast Journal 2011, 18: 8-15. PMID: 22107336, DOI: 10.1111/j.1524-4741.2011.01197.x.Peer-Reviewed Original ResearchConceptsWhole breast radiationDuctal carcinomaAppropriateness CriteriaMultiple phase III studiesAppropriateness of imagingPhase III studyACR Appropriateness CriteriaExpert panelRadiology Appropriateness CriteriaEvidence-based guidelinesMultidisciplinary expert panelOmission of radiationPartial breast radiationSpecific clinical conditionsCurrent medical literatureNon-invasive tumorsInvasive relapseBreast radiationLimited diseaseIII studyPeer-reviewed journalsLocal recurrenceAppropriate patientsTumor bedClinical guidelinesBreast Conservation Therapy for Ductal Carcinoma In Situ (DCIS): Is there a difference in Clinical-Pathologic Features and Long Term Outcomes in Occult, Mammographically-Detected Disease Compared with DCIS Presenting with Physical Findings?
Bai H, Lannin D, Higgins S, Motwani S, Hafty B, Goyal S, Wilson L, Evans S, Moran M. Breast Conservation Therapy for Ductal Carcinoma In Situ (DCIS): Is there a difference in Clinical-Pathologic Features and Long Term Outcomes in Occult, Mammographically-Detected Disease Compared with DCIS Presenting with Physical Findings? International Journal Of Radiation Oncology • Biology • Physics 2011, 81: s245. DOI: 10.1016/j.ijrobp.2011.06.1716.Peer-Reviewed Original Research
2010
Racial Disparities in Treatment Outcomes for African American Women with Ductal Carcinoma In Situ Receiving Whole Breast Irradiation following Breast Conserving Surgery
Nelson C, Goyal S, Moran M, Motwani S, Haffty B. Racial Disparities in Treatment Outcomes for African American Women with Ductal Carcinoma In Situ Receiving Whole Breast Irradiation following Breast Conserving Surgery. International Journal Of Radiation Oncology • Biology • Physics 2010, 78: s222. DOI: 10.1016/j.ijrobp.2010.07.533.Peer-Reviewed Original ResearchDuctal Carcinoma In Situ With Microinvasion: Prognostic Implications, Long-Term Outcomes, and Role of Axillary Evaluation
Parikh RR, Haffty BG, Lannin D, Moran MS. Ductal Carcinoma In Situ With Microinvasion: Prognostic Implications, Long-Term Outcomes, and Role of Axillary Evaluation. International Journal Of Radiation Oncology • Biology • Physics 2010, 82: 7-13. PMID: 20950955, DOI: 10.1016/j.ijrobp.2010.08.027.Peer-Reviewed Original ResearchConceptsDistant relapse-free survivalLocal-regional relapseClinical-pathologic featuresRelapse-free survivalBreast conservation therapyLong-term outcomesOverall survivalAxillary evaluationAxillary metastasesIndependent predictorsDuctal carcinomaCox proportional hazards analysisPresence of microinvasionSurgical axillary evaluationAdjuvant hormonal therapyProportional hazards analysisHormonal therapyAggressive treatmentDistant failureMargin statusSurgical evaluationConservation therapyPrognostic implicationsMean ageUnivariate analysis
2009
The Yale University Experience of Early‐Stage Invasive Lobular Carcinoma (ILC) and Invasive Ductal Carcinoma (IDC) Treated with Breast Conservation Treatment (BCT): Analysis of Clinical‐Pathologic Features, Long‐Term Outcomes, and Molecular Expression of COX‐2, Bcl‐2, and p53 as a Function of Histology
Moran MS, Yang Q, Haffty BG. The Yale University Experience of Early‐Stage Invasive Lobular Carcinoma (ILC) and Invasive Ductal Carcinoma (IDC) Treated with Breast Conservation Treatment (BCT): Analysis of Clinical‐Pathologic Features, Long‐Term Outcomes, and Molecular Expression of COX‐2, Bcl‐2, and p53 as a Function of Histology. The Breast Journal 2009, 15: 571-578. PMID: 19995377, DOI: 10.1111/j.1524-4741.2009.00833.x.Peer-Reviewed Original ResearchConceptsBreast conservation treatmentInvasive lobular carcinomaInvasive ductal carcinomaEarly-stage invasive lobular carcinomaClinical-pathologic featuresContralateral breast cancerCOX-2Breast relapseILC patientsDuctal carcinomaBreast cancerER/PR/HERBcl-2Cause-specific survivalLong-term outcomesTriple-negative tumorsChemo-preventive strategiesYears of ageImmuno-histochemical analysisExpression of p53Function of histologyDistant relapseInvasive lobularNodal statusContralateral breastLow-risk Ductal Carcinoma In Situ (DCIS) Treated with Breast Conserving Surgery and Radiotherapy: Comparison with Intergroup Study E5194
Motwani S, Galper S, Goyal S, Moran M, Haffty B. Low-risk Ductal Carcinoma In Situ (DCIS) Treated with Breast Conserving Surgery and Radiotherapy: Comparison with Intergroup Study E5194. International Journal Of Radiation Oncology • Biology • Physics 2009, 75: s53-s54. DOI: 10.1016/j.ijrobp.2009.07.143.Peer-Reviewed Original ResearchClinical-Pathologic Features and Long-Term Outcomes of Tubular Carcinoma of the Breast Compared With Invasive Ductal Carcinoma Treated With Breast Conservation Therapy
Liu GF, Yang Q, Haffty BG, Moran MS. Clinical-Pathologic Features and Long-Term Outcomes of Tubular Carcinoma of the Breast Compared With Invasive Ductal Carcinoma Treated With Breast Conservation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2009, 75: 1304-1308. PMID: 19386432, DOI: 10.1016/j.ijrobp.2008.12.070.Peer-Reviewed Original ResearchConceptsClinical-pathologic featuresInvasive ductal carcinomaRelapse-free survivalBreast conservation therapyLong-term outcomesConservation therapyTC cohortTumor RegistryDuctal carcinomaTubular carcinomaInstitutional experienceBreast cancer-related deathsNodal relapse-free survivalInstitution's tumor registryCentral pathology reviewHormone receptor positivityCancer-related deathPT1 diseaseConservative surgeryPN0 diseasePathology reviewClinical outcomesDistant metastasisRare subtypeRadiation therapy
2008
Ductal Carcinoma In Situ with Microinvasion: Prognostic Implications, Long-term Outcomes, and Role of Axillary Evaluation
Parikh R, Haffty B, Moran M. Ductal Carcinoma In Situ with Microinvasion: Prognostic Implications, Long-term Outcomes, and Role of Axillary Evaluation. International Journal Of Radiation Oncology • Biology • Physics 2008, 72: s150-s151. DOI: 10.1016/j.ijrobp.2008.06.481.Peer-Reviewed Original Research
1997
Conservatively Treated Breast Cancer: Outcome by Histologic Subtype
Haffty B, Perrotta P, Ward B, Moran M, Beinfield M, McKhann C, Fischer D, Carter D. Conservatively Treated Breast Cancer: Outcome by Histologic Subtype. The Breast Journal 1997, 3: 7-14. DOI: 10.1111/j.1524-4741.1997.tb00134.x.Peer-Reviewed Original ResearchHistologic subtypeRecurrence-free rateRelapse rateDistant metastasisDuctal carcinomaRecurrence rateFocal invasionBreast cancerDistant recurrence-free survival rateIpsilateral breast tumor recurrence (IBTR) ratesIpsilateral breast tumor recurrenceRecurrence-free survival ratesDistant metastasis-free rateEarly-stage breast cancerSignificant differencesYale-New Haven HospitalPathological nodal involvementPrimary histologic subtypeBreast tumor recurrenceTumor recurrence rateBreast cancer patientsBreast conservation therapyMetastasis-free rateLow metastatic potentialAxillary dissection