2020
Treatment of granuloma annulare and suppression of proinflammatory cytokine activity with tofacitinib
Wang A, Rahman NT, McGeary MK, Murphy M, McHenry A, Peterson D, Bosenberg M, Flavell RA, King B, Damsky W. Treatment of granuloma annulare and suppression of proinflammatory cytokine activity with tofacitinib. Journal Of Allergy And Clinical Immunology 2020, 147: 1795-1809. PMID: 33317858, DOI: 10.1016/j.jaci.2020.10.012.Peer-Reviewed Original ResearchMeSH KeywordsAgedCD4-Positive T-LymphocytesCytokinesFibroblastsGranuloma AnnulareHumansJanus Kinase InhibitorsMacrophagesMiddle AgedPiperidinesPyrimidinesSequence Analysis, RNASkinConceptsGranuloma annulareIL-15Oncostatin MT cellsEffective treatmentOpen-label clinical trialSingle-cell RNA sequencingEfficacy of tofacitinibIL-21 productionCutaneous inflammatory disordersIFN-γ productionJanus kinase inhibitorProinflammatory cytokine activityActivity of IFNGA pathogenesisIL-6 family cytokinesDisease remissionClinical improvementSystemic inflammationIL-21RNA sequencingMacrophage accumulationInflammatory disordersInflammatory polarizationClinical trials
2019
Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare
Damsky W, Thakral D, McGeary MK, Leventhal J, Galan A, King B. Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare. Journal Of The American Academy Of Dermatology 2019, 82: 612-621. PMID: 31185230, PMCID: PMC7590533, DOI: 10.1016/j.jaad.2019.05.098.Peer-Reviewed Original ResearchConceptsGranuloma annulareCutaneous sarcoidosisPathway activationCutaneous granulomatous disordersRecalcitrant cutaneous sarcoidosisSkin biopsy specimensSignal regulatory protein αJAK-STAT pathway activationTranscription (JAK/STAT) pathway activationRegulatory protein αRecalcitrant sarcoidosisSarcoidosis activityDisease remissionConsecutive patientsGranulomatous disorderProspective evaluationBiopsy specimensHistologic resolutionSkin biopsiesMean improvementSarcoidosisImmunohistochemical analysisJAK inhibitorsJAK inhibitionPatients