2022
Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis
Damsky W, Wang A, Kim DJ, Young BD, Singh K, Murphy MJ, Daccache J, Clark A, Ayasun R, Ryu C, McGeary MK, Odell ID, Fazzone-Chettiar R, Pucar D, Homer R, Gulati M, Miller EJ, Bosenberg M, Flavell RA, King B. Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis. Nature Communications 2022, 13: 3140. PMID: 35668129, PMCID: PMC9170782, DOI: 10.1038/s41467-022-30615-x.Peer-Reviewed Original ResearchConceptsType 1 immunityInternal organ involvementOrgan involvementT cell-derived IFNIdiopathic inflammatory disorderOpen-label trialMonths of treatmentType 1 cytokinesJanus kinase inhibitorImmunologic changesLongstanding sarcoidosisSarcoidosis activitySarcoidosis symptomsClinical improvementCutaneous sarcoidosisSecondary outcomesComplete responsePrimary outcomeTofacitinib treatmentActivity scoreCytokine mediatorsIL-12IL-15IL-6Inflammatory disorders
2020
Treatment of granuloma annulare and suppression of proinflammatory cytokine activity with tofacitinib
Wang A, Rahman NT, McGeary MK, Murphy M, McHenry A, Peterson D, Bosenberg M, Flavell RA, King B, Damsky W. Treatment of granuloma annulare and suppression of proinflammatory cytokine activity with tofacitinib. Journal Of Allergy And Clinical Immunology 2020, 147: 1795-1809. PMID: 33317858, DOI: 10.1016/j.jaci.2020.10.012.Peer-Reviewed Original ResearchConceptsGranuloma annulareIL-15Oncostatin MT cellsEffective treatmentOpen-label clinical trialSingle-cell RNA sequencingEfficacy of tofacitinibIL-21 productionCutaneous inflammatory disordersIFN-γ productionJanus kinase inhibitorProinflammatory cytokine activityActivity of IFNGA pathogenesisIL-6 family cytokinesDisease remissionClinical improvementSystemic inflammationIL-21RNA sequencingMacrophage accumulationInflammatory disordersInflammatory polarizationClinical trials