Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents
Perov S, Lidor O, Salinas N, Golan N, Fligelman E, Deshmukh M, Willbold D, Landau M. Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents. PLOS Pathogens 2019, 15: e1007978. PMID: 31469892, PMCID: PMC6748439, DOI: 10.1371/journal.ppat.1007978.Peer-Reviewed Original ResearchConceptsDisease-associated amyloidsStructural insightsCross-seeded fibrillationMajor curli subunitBiofilm formationHost cell adhesionCurli amyloid fibrilsAmyloid-forming segmentAlzheimer's disease-associated amyloidAnti-amyloid compoundsCurli formationCurli subunitsPathological amyloidsAmyloidogenic regionsMicrobial sourcesEnvironmental stressorsAmyloid interactionsCell adhesionAnti-biofilm agentsΒ-sheetCsgANeurodegenerative diseasesSalmonella typhimuriumStructural linkStructural resemblance