Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence
Castelo-Branco C, Gambacciani M, Cano A, Minkin M, Rachoń D, Ruan X, Beer A, Schnitker J, Henneicke-von Zepelin H, Pickartz S. Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence. Climacteric 2020, 24: 109-119. PMID: 33021111, DOI: 10.1080/13697137.2020.1820477.Peer-Reviewed Original ResearchConceptsClimacteric symptomsMenopausal symptomsBetter benefit-risk profileLow-dose transdermal estradiolICR/Evidence-based treatment optionsEstrogen-sensitive organsEstrogen-sensitive tissuesPsychological menopausal symptomsMinor adverse eventsBenefit-risk profileEvidence of hepatotoxicityGood safety profileStandardized mean differenceHormone-dependent diseasesSystematic literature searchTransdermal estradiolAdverse eventsGood tolerabilitySafety profileTreatment optionsSt. John's wortHerbal therapyHormone levelsClinical data