Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence
Eren R, Reverte M, Rossi M, Hartley M, Castiglioni P, Prevel F, Martin R, Desponds C, Lye L, Drexler S, Reith W, Beverley S, Ronet C, Fasel N. Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence. Cell Host & Microbe 2016, 20: 318-328. PMID: 27593513, PMCID: PMC5493041, DOI: 10.1016/j.chom.2016.08.001.Peer-Reviewed Original ResearchConceptsLeishmania RNA virus 1Innate immune responseParasite persistenceImmune responseMiR-155Anti-viral innate immune responsesMacrophage survivalMiR-155-deficient miceTLR-3 activationMiR-155 expressionMammalian host responseMammalian innate immune responseLesional macrophagesParasitic infectionsHost responseDisease severityParasite burdenLeishmania guyanensisPharmacological inhibitionVirus 1Akt phosphorylationAkt activationReduced levelsSurvivalMice