2010
Spatiotemporal organization, regulation, and functions of tractions during neutrophil chemotaxis
Shin ME, He Y, Li D, Na S, Chowdhury F, Poh YC, Collin O, Su P, de Lanerolle P, Schwartz MA, Wang N, Wang F. Spatiotemporal organization, regulation, and functions of tractions during neutrophil chemotaxis. Blood 2010, 116: 3297-3310. PMID: 20616216, PMCID: PMC2995358, DOI: 10.1182/blood-2009-12-260851.Peer-Reviewed Original Research
2007
Blocking p21-activated Kinase Reduces Lipopolysaccharide-induced Acute Lung Injury by Preventing Polymorphonuclear Leukocyte Infiltration
Reutershan J, Stockton R, Zarbock A, Sullivan GW, Chang D, Scott D, Schwartz MA, Ley K. Blocking p21-activated Kinase Reduces Lipopolysaccharide-induced Acute Lung Injury by Preventing Polymorphonuclear Leukocyte Infiltration. American Journal Of Respiratory And Critical Care Medicine 2007, 175: 1027-1035. PMID: 17322107, PMCID: PMC1899271, DOI: 10.1164/rccm.200612-1822oc.Peer-Reviewed Original ResearchConceptsAcute lung injuryLung injuryPMN migrationPolymorphonuclear leukocytesAlveolar spaceLipopolysaccharide-induced lung injuryMurine lung injuryPolymorphonuclear leukocyte infiltrationLeukocyte-endothelial interactionsAlveolo-capillary membraneOxidative burstRole of PAKsLeukocyte infiltrationChemokine receptorsLung interstitiumMurine modelExcessive recruitmentPMN chemoattractantInjuryCytoskeletal actin polymerizationAdhesion moleculesCritical mediatorCell migrationAttractive targetPAK phosphorylation