2014
Simvastatin Enhances the Effects of Radiotherapy and Cetuximab on a Cell Line (FaDu) Derived from a Squamous Cell Carcinoma of Head and Neck
de Llobet L, Baro M, Mesia R, Balart J. Simvastatin Enhances the Effects of Radiotherapy and Cetuximab on a Cell Line (FaDu) Derived from a Squamous Cell Carcinoma of Head and Neck. Translational Oncology 2014, 7: 513-522. PMID: 25171892, PMCID: PMC4202798, DOI: 10.1016/j.tranon.2014.02.008.Peer-Reviewed Original ResearchEpidermal growth factor receptorExtracellular signal-regulated kinases 1Signal-regulated kinases 1Cell linesEfficient epidermal growth factor receptorPhosphorylated extracellular signal-regulated kinases 1Growth factor receptorA431 cell lineSignal transducerKinase BKinase 1Cancer progressionSynthesis of cholesterolFactor receptorCaspase-3Cell proliferationFaDu cellsCell culturesStatin simvastatinClonogenic assayTumor growthWound healingIsoprenoidsOncoproteinApoptosis
2010
Cetuximab May Inhibit Tumor Growth and Angiogenesis Induced by Ionizing Radiation: A Preclinical Rationale for Maintenance Treatment After Radiotherapy
Pueyo G, Mesia R, Figueras A, Lozano A, Baro M, Vazquez S, Capella G, Balart J. Cetuximab May Inhibit Tumor Growth and Angiogenesis Induced by Ionizing Radiation: A Preclinical Rationale for Maintenance Treatment After Radiotherapy. The Oncologist 2010, 15: 976-986. PMID: 20798193, PMCID: PMC3228040, DOI: 10.1634/theoncologist.2008-0290.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorKi-67 indexMicrovessel densityAggressive phenotypeTumor growthHigh Ki-67 indexCetuximab maintenance therapyMicroscopic residual diseaseBenefits of radiotherapyVascular endothelial growth factor (VEGF) secretionUntreated cellsGrowth factor secretionMechanism of actionCetuximab maintenanceGrowth factor receptorMaintenance therapyAdjuvant therapyPreclinical rationaleMaintenance treatmentResidual diseaseCarcinoma cell linesClinical evaluationExtracellular signal-related kinaseIrradiated cellsCetuximab