2019
Targeting Unique Synthetic Lethal Interactions between PI3K and MYC in B-ALL
Xiao G, Kume K, Geng H, Han T, Klemm L, Müschen M. Targeting Unique Synthetic Lethal Interactions between PI3K and MYC in B-ALL. Blood 2019, 134: 3785. DOI: 10.1182/blood-2019-128719.Peer-Reviewed Original ResearchMYC protein levelsPI3KCell deathMYC overexpressionPTEN deletionRescue effectProtein levelsPI3K hyperactivationMYC protein stabilityTranscription factor Pax5Wild-type MycDegradation of MycSynthetic lethal interactionsGlutamine consumptionGene expression profilesCellular ATP levelsInhibition of glutaminolysisATP levelsPTEN inhibitor SF1670Deletion of PTENMyc mutantsPI3K pathwayPI3K subunitsMyc proteinProtein gene
2016
PP2A Balances Glucose Metabolism and Foxo Activation to Maintain Cellular Redox Homeostasis in Acute Lymphoblastic Leukemia
Xiao G, Chen Z, Daniel B, Chan L, Geng H, Jiang X, Müschen M. PP2A Balances Glucose Metabolism and Foxo Activation to Maintain Cellular Redox Homeostasis in Acute Lymphoblastic Leukemia. Blood 2016, 128: 1056. DOI: 10.1182/blood.v128.22.1056.1056.Peer-Reviewed Original ResearchLineage-specific rolesPro-survival roleLB-100PP2A subunitsRedox homeostasisH2AX phosphorylationUnexpected rolePI3K-AktFunction of PP2AProtein phosphatase 2ACellular redox homeostasisSer/ThrCatalytic subunit CAnti-oxidant gene expressionS6 ribosomal proteinHigh glycolytic fluxRescue effectGrowth competition assaysLeukemia cellsPentose phosphate pathway fluxHigher reactive oxygen species (ROS) levelsReduced cell growthPP2A functionSmall molecule inhibitorsFOXO factors