1998
Functional polarity of Na+/H+and Cl−/ HCO 3 − exchangers in a rat cholangiocyte cell line
Spirlì C, Granato A, Zsembery A, Anglani F, Okolicsànyi L, LaRusso N, Crepaldi G, Strazzabosco M. Functional polarity of Na+/H+and Cl−/ HCO 3 − exchangers in a rat cholangiocyte cell line. American Journal Of Physiology 1998, 275: g1236-g1245. PMID: 9843758, DOI: 10.1152/ajpgi.1998.275.6.g1236.Peer-Reviewed Original ResearchConceptsRat cholangiocyte cell lineCholangiocyte cell lineHOE 642Intrahepatic bile duct cellsCell linesNHE isoformsBile duct cellsAcid-base transportersPHi recoveryApical administrationBasolateral amilorideSeparate perfusionFirst functional descriptionAcid loadBasolateral aspectNHE3 gene expressionDuct cellsGene expressionRT-PCRApical amilorideElectrolyte transportAE2 mRNAAmilorideHCO-3IsoformsPurinergic regulation of acid/base transport in human and rat biliary epithelial cell lines
Zsembery Á, Spirlì C, Granato A, LaRusso N, Okolicsanyi L, Crepaldi G, Strazzabosco M. Purinergic regulation of acid/base transport in human and rat biliary epithelial cell lines. Hepatology 1998, 28: 914-920. PMID: 9755225, DOI: 10.1002/hep.510280403.Peer-Reviewed Original ResearchConceptsCholangiocyte cell lineNHE activityPurinergic agonistsBiliary epithelial cell lineExtracellular ATPCell linesIntracellular cyclic adenosine monophosphate (cAMP) concentrationsBiliary HCO3- secretionRat cholangiocyte cell lineCyclic adenosine monophosphate concentrationsAdenosine receptor agonistsBiliary epithelial cellsMz-ChA-1 cellsAdenosine monophosphate concentrationsSynergistic stimulatory effectApical administrationEpithelial cell lineReceptor agonistP2Y2 receptorPurinergic receptorsBile volumePharmacological profileApical Cl- channelsBasolateral administrationHCO3- secretion
1997
New insights into cholangiocyte physiology
Strazzabosco M. New insights into cholangiocyte physiology. Journal Of Hepatology 1997, 27: 945-952. PMID: 9382988, DOI: 10.1016/s0168-8278(97)80338-8.Peer-Reviewed Original ResearchEpstein-Barr virus-associated post-transplant lympho-proliferative disease of donor origin in liver transplant recipients
Strazzabosco M, Corneo B, Iemmolo R, Menin C, Gerunda G, Bonaldi L, Merenda R, Neri D, Poletti A, Montagna M, Del Mistro A, Faccioli A, D'Andrea E. Epstein-Barr virus-associated post-transplant lympho-proliferative disease of donor origin in liver transplant recipients. Journal Of Hepatology 1997, 26: 926-934. PMID: 9126809, DOI: 10.1016/s0168-8278(97)80262-0.Peer-Reviewed Original ResearchConceptsPost-transplant lymphoproliferative diseaseLiver transplant recipientsOrthotopic liver transplant recipientsLymphoproliferative diseaseTransplant recipientsDonor originB lymphocytesDonor B lymphocytesEBV-specific probesPost-transplant lymphomaOrthotopic liver transplantEpstein-Barr virus sequencesSolid organ transplantationPossible risk factorsLympho-proliferative diseaseNeoplastic B cellsLiver transplantEBV DNAHepatic hilumProspective studyHodgkin's lymphomaPolymerase chain reactionPotential complicationsRisk factorsReal incidence