2010
Cortico-Thalamic Connectivity is Vulnerable to Nicotine Exposure During Early Postnatal Development through α4/β2/α5 Nicotinic Acetylcholine Receptors
Heath CJ, King SL, Gotti C, Marks MJ, Picciotto MR. Cortico-Thalamic Connectivity is Vulnerable to Nicotine Exposure During Early Postnatal Development through α4/β2/α5 Nicotinic Acetylcholine Receptors. Neuropsychopharmacology 2010, 35: 2324-2338. PMID: 20736992, PMCID: PMC2955839, DOI: 10.1038/npp.2010.130.Peer-Reviewed Original ResearchConceptsDevelopmental nicotine exposureNicotine exposureNicotinic acetylcholine receptorsAcetylcholine receptorsΑ5 nicotinic acetylcholine receptorConstituents of smokeEarly post-natal periodPrimary addictive componentΑ5 nAChR subunitTobacco smoke exposureCortico-thalamic connectivityPost-natal periodEarly postnatal developmentPassive avoidance behaviorCorticothalamic neuronsAddictive componentCorticothalamic projectionsSmoke exposureReceptor subtypesNAChR subtypesDevelopmental exposureMouse modelNeurodevelopmental periodAnimal modelsBehavioral alterations
2005
Impaired Synaptic Plasticity and Learning in Mice Lacking β-Adducin, an Actin-Regulating Protein
Rabenstein RL, Addy NA, Caldarone BJ, Asaka Y, Gruenbaum LM, Peters LL, Gilligan DM, Fitzsimonds RM, Picciotto MR. Impaired Synaptic Plasticity and Learning in Mice Lacking β-Adducin, an Actin-Regulating Protein. Journal Of Neuroscience 2005, 25: 2138-2145. PMID: 15728854, PMCID: PMC1352335, DOI: 10.1523/jneurosci.3530-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsAvoidance LearningCalmodulin-Binding ProteinsConditioning, ClassicalCytoskeletonDendritesElectroshockFearFemaleFreezing Reaction, CatalepticGyrus CinguliHippocampusLearning DisabilitiesMaleMaze LearningMemory DisordersMiceMice, Inbred C57BLMice, KnockoutMice, Neurologic MutantsNerve Tissue ProteinsNeuronal PlasticityNucleus AccumbensRNA, MessengerConceptsBeta-adducinActin regulating proteinsCAMP-dependent mannerSynaptic plasticityActin cytoskeletonΒ-adducinCytoskeletal organizationPlasma membraneAdducinCellular mechanismsActivity-dependent synaptic plasticitySitu hybridizationPostsynaptic densityProteinPlasticitySpine morphologyImportant roleCytoskeletonSynaptic stimulationFamilyImpaired synaptic plasticityLong-term potentiationMiceMRNAHybridization
2003
Conditional Expression in Corticothalamic Efferents Reveals a Developmental Role for Nicotinic Acetylcholine Receptors in Modulation of Passive Avoidance Behavior
King SL, Marks MJ, Grady SR, Caldarone BJ, Koren AO, Mukhin AG, Collins AC, Picciotto MR. Conditional Expression in Corticothalamic Efferents Reveals a Developmental Role for Nicotinic Acetylcholine Receptors in Modulation of Passive Avoidance Behavior. Journal Of Neuroscience 2003, 23: 3837-3843. PMID: 12736354, PMCID: PMC6742204, DOI: 10.1523/jneurosci.23-09-03837.2003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvoidance LearningBehavior, AnimalBinding, CompetitiveCerebral CortexElectroshockGene Expression Regulation, DevelopmentalMiceMice, Inbred C57BLMice, Inbred ICRMice, KnockoutMice, TransgenicNeurons, EfferentNicotineNicotinic AgonistsPresynaptic TerminalsReceptors, NicotinicTetracyclineThalamusTransgenesConceptsPrenatal nicotine exposureNicotinic acetylcholine receptorsPassive avoidanceLines of miceNicotine exposureTransgenic miceAcetylcholine receptorsHigh-affinity nicotinic acetylcholine receptorsTetracycline-regulated transgenic systemHigh-affinity nicotinic receptorsPotential neuroanatomical substratesRubidium efflux assaysHigh-affinity nAChRsEffects of nicotineSpecific neuronal populationsPassive avoidance behaviorAttention deficit hyperactivity disorderWild-type animalsDeficit hyperactivity disorderPresynaptic nAChRsCorticothalamic neuronsSite of actionNicotinic receptorsNeuronal populationsCognitive impairment
2002
Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or Inhibitor 1
Zachariou V, Benoit-Marand M, Allen PB, Ingrassia P, Fienberg AA, Gonon F, Greengard P, Picciotto MR. Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or Inhibitor 1. Biological Psychiatry 2002, 51: 612-620. PMID: 11955461, DOI: 10.1016/s0006-3223(01)01318-x.Peer-Reviewed Original ResearchAnimalsAvoidance LearningBehavior, AnimalCocaineCorpus StriatumDopamineDopamine and cAMP-Regulated Phosphoprotein 32Dopamine Uptake InhibitorsElectric StimulationElectrochemistryMaleMiceMice, KnockoutMotor ActivityNerve Tissue ProteinsPhosphoprotein PhosphatasesPhosphoproteinsProtein Phosphatase 1Proteins
2000
Gender Differences in Learned Helplessness Behavior Are Influenced by Genetic Background
Caldarone B, George T, Zachariou V, Picciotto M. Gender Differences in Learned Helplessness Behavior Are Influenced by Genetic Background. Pharmacology Biochemistry And Behavior 2000, 66: 811-817. PMID: 10973520, DOI: 10.1016/s0091-3057(00)00271-9.Peer-Reviewed Original ResearchConceptsEscape latencyInescapable shockHelplessness behaviorGenetic backgroundInescapable shock pretreatmentControl miceMale C57BL/6JMixed genetic backgroundB6 xGender differencesNonshocked controlsB6 femalesMiceB6 malesEscape performanceCommon genetic backgroundKnockout modelsHelplessness modelShock pretreatmentMalesFemalesLatencyPainBrain Localization and Behavioral Impact of the G-Protein-Gated K+ Channel Subunit GIRK4
Wickman K, Karschin C, Karschin A, Picciotto M, Clapham D. Brain Localization and Behavioral Impact of the G-Protein-Gated K+ Channel Subunit GIRK4. Journal Of Neuroscience 2000, 20: 5608-5615. PMID: 10908597, PMCID: PMC6772558, DOI: 10.1523/jneurosci.20-15-05608.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvoidance LearningBehavior, AnimalBrain ChemistryChick EmbryoFemaleG Protein-Coupled Inwardly-Rectifying Potassium ChannelsGene ExpressionIn Situ HybridizationIon Channel GatingLocomotionMaleMaze LearningMemoryMiceMice, Inbred C57BLMice, KnockoutPotassium ChannelsPotassium Channels, Inwardly RectifyingRNA, MessengerConceptsGIRK4 mRNAG-protein-gated potassium (GIRK) channelsCortical pyramidal neuronsVentromedial hypothalamic nucleusParaventricular thalamic nucleusMorris water mazeG-Protein-GatedPassive avoidance paradigmMammalian nervous systemWild-type controlsEndopiriform nucleusPyramidal neuronsGlobus pallidusSynaptic inhibitionBrainstem nucleiHypothalamic nucleiPain perceptionThalamic nucleiInsular cortexNervous systemNeuronal populationsWater mazeLocomotor activityMouse brainGIRK subunits
1995
Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain
Picciotto M, Zoli M, Léna C, Bessis A, Lallemand Y, LeNovère N, Vincent P, Pich E, Brûlet P, Changeux J. Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature 1995, 374: 65-67. PMID: 7870173, DOI: 10.1038/374065a0.Peer-Reviewed Original ResearchConceptsHigh-affinity nicotine receptorsNeuronal nicotinic acetylcholine receptorsBrains of miceΒ2-/- miceNicotinic acetylcholine receptorsThalamic neuronsNicotine applicationFunctional nAChRsNicotine receptorsBrain slicesNicotinic subunitsAbnormal avoidanceAcetylcholine receptorsAspects of behaviorHigh-affinity binding sitesMutant miceElectrophysiological recordingsPassive avoidanceAssociative memoryMiceNicotineNeuronal nicotinic subunitsNon-mutant siblingsBrainReceptors