Identification of Four Classes of Brain Nicotinic Receptors Using β2 Mutant Mice
Zoli M, Léna C, Picciotto M, Changeux J. Identification of Four Classes of Brain Nicotinic Receptors Using β2 Mutant Mice. Journal Of Neuroscience 1998, 18: 4461-4472. PMID: 9614223, PMCID: PMC6792706, DOI: 10.1523/jneurosci.18-12-04461.1998.Peer-Reviewed Original ResearchConceptsBeta2-/- miceElectrophysiological experimentsBrain regionsNeuronal nicotinic acetylcholine receptor subunitBrain nicotinic receptorsNicotinic acetylcholine receptor subunitsMost brain regionsPatch-clamp recordingsReceptor autoradiography studiesOrder of potencyDifferent brain areasAcetylcholine receptor subunitsThin brain slicesDifferent brain regionsIndividual alpha subunitsAutoradiography studiesBrain slicesNicotinic receptorsNicotinic agonistsHigh affinitySubunit compositionBrain areasAlpha subunitAlpha7 subunitType 2