Local Application of Neurotrophins Specifies Axons Through Inositol 1,4,5-Trisphosphate, Calcium, and Ca2+/Calmodulin–Dependent Protein Kinases
Nakamuta S, Funahashi Y, Namba T, Arimura N, Picciotto MR, Tokumitsu H, Soderling TR, Sakakibara A, Miyata T, Kamiguchi H, Kaibuchi K. Local Application of Neurotrophins Specifies Axons Through Inositol 1,4,5-Trisphosphate, Calcium, and Ca2+/Calmodulin–Dependent Protein Kinases. Science Signaling 2011, 4: ra76. PMID: 22087032, DOI: 10.1126/scisignal.2002011.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorNeurotrophin-3Neurotrophin brain-derived neurotrophic factorLocal applicationImmature neuritesCultured hippocampal neuronsAxon specificationSpecific intracellular pathwaysNeurotrophic factorCortical neuronsHippocampal neuronsNeurotrophin receptorParacrine fashionCultured neuronsDependent protein kinase kinaseDependent protein kinaseNeuronsProtein kinase kinaseAxonsIntracellular pathwaysDependent fashionLocal activationNeuritesNeurite outgrowthGrowth cones