2022
Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability
Ghosh JC, Perego M, Agarwal E, Bertolini I, Wang Y, Goldman AR, Tang HY, Kossenkov AV, Landis CJ, Languino LR, Plow EF, Morotti A, Ottobrini L, Locatelli M, Speicher DW, Caino MC, Cassel J, Salvino JM, Robert ME, Vaira V, Altieri DC. Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2115624119. PMID: 35177476, PMCID: PMC8872753, DOI: 10.1073/pnas.2115624119.Peer-Reviewed Original ResearchMeSH KeywordsCell DeathCell Line, TumorCell MovementCell ProliferationEpithelial-Mesenchymal TransitionHumansMitochondriaMitochondrial DynamicsMitochondrial ProteinsMuscle ProteinsNeoplasm InvasivenessNeoplasm MetastasisNeoplasmsNeoplastic ProcessesProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktReactive Oxygen SpeciesSignal TransductionConceptsEpithelial-mesenchymal transitionGene expression programsTherapeutic vulnerabilitiesTumor cell movementCytokine/chemokine signalingExpression programsTherapeutic targetCell movementMitochondrial dynamicsEssential scaffoldMitochondrial structureSurvival signalingMitochondrial integrityCancer metabolismStress responseActionable therapeutic targetsCell deathChemokine signalingMitochondriaSmall-molecule drug screensCell proliferationOxidative damageInnate immunityMetastatic disseminationHuman tumors
1990
Squamous cell carcinoma of the uterine cervix--a review with emphasis on prognostic factors and unusual variants.
Robert M, Fu Y. Squamous cell carcinoma of the uterine cervix--a review with emphasis on prognostic factors and unusual variants. Seminars In Diagnostic Pathology 1990, 7: 173-89. PMID: 2218146.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaCell carcinomaPathological features of squamous cell carcinomaIncidence of squamous cell carcinomaRisk of lymph node metastasisFeatures of squamous cell carcinomaSmall cell undifferentiated carcinomaInvasive squamous cell carcinomaPathological featuresCervical conization specimensCell undifferentiated carcinomaLymph node metastasisCompleteness of excisionEarly invasive carcinomaPathologically distinct variantCell typesPrognostic pathologic findingsConization specimensUterine cervixTumor dimensionUndifferentiated carcinomaLocalized diseasePrognostic factorsInvasive carcinomaLymphatic invasion