2023
Guidelines for best practices in monitoring established coeliac disease in adult patients
Elli L, Leffler D, Cellier C, Lebwohl B, Ciacci C, Schumann M, Lundin K, Chetcuti Zammit S, Sidhu R, Roncoroni L, Bai J, Lee A, Dennis M, Robert M, Rostami K, Khater S, Comino I, Cebolla A, Branchi F, Verdu E, Stefanolo J, Wolf R, Bergman-Golden S, Trott N, Scudeller L, Zingone F, Scaramella L, Sanders D. Guidelines for best practices in monitoring established coeliac disease in adult patients. Nature Reviews Gastroenterology & Hepatology 2023, 21: 198-215. PMID: 38110546, DOI: 10.1038/s41575-023-00872-2.Peer-Reviewed Original ResearchConceptsCoeliac diseaseLevel of evidenceLife-long gluten-free dietGluten-free dietMucosal atrophyAdult patientsCirculating autoantibodiesFollow-upGenetic predispositionImmunological diseasesRecommendations AssessmentMonitoring patientsClinical guidelinesEvidence levelPatientsConsumption of glutenDiagnosisDiseaseGuidelinesScientific societiesCeDAutoantibodiesGastroenterologistsAtrophyStandardizing Randomized Controlled Trials in Celiac Disease: An International Multidisciplinary Appropriateness Study
Lebwohl B, Ma C, Lagana S, Pai R, Baker K, Zayadi A, Hogan M, Bouma G, Cellier C, Goldsmith J, Lundin K, Pinto-Sanchez M, Robert M, Rubio-Tapia A, Sanders D, Schaeffer D, Semrad C, Silvester J, Verdú E, Verma R, Wu T, Feagan B, Crowley E, Jairath V, Murray J. Standardizing Randomized Controlled Trials in Celiac Disease: An International Multidisciplinary Appropriateness Study. Gastroenterology 2023, 166: 88-102. PMID: 37704112, DOI: 10.1053/j.gastro.2023.08.051.Peer-Reviewed Original ResearchConceptsRandomized controlled trialsSecondary patient-reported outcome measuresOutcome measuresRandomized controlled trial designPatient-reported outcome measuresControlled trialsGluten challengeStandard Randomized Controlled TrialPatient-reported outcomesGluten-free dietReversal of histological changesMethods studyCeliac diseaseEligibility criteriaHistological end pointsPrevention of relapseEffective pharmacological optionsAppropriate studiesTrial outcomesExclusion criteriaClinical trial designTrial designTreatment of celiac diseasePediatric patientsPharmacological options
2021
Renalase is a novel tissue and serological biomarker in pancreatic ductal adenocarcinoma
Gao Y, Wang M, Guo X, Hu J, Chen TM, Finn S, Lacy J, Kunstman JW, H. C, Bellin MD, Robert ME, Desir GV, Gorelick FS. Renalase is a novel tissue and serological biomarker in pancreatic ductal adenocarcinoma. PLOS ONE 2021, 16: e0250539. PMID: 34587190, PMCID: PMC8480607, DOI: 10.1371/journal.pone.0250539.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Pancreatic DuctalCase-Control StudiesFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedMonoamine OxidaseNeoplasm GradingPancreatic NeoplasmsPrognosisProspective StudiesRetrospective StudiesSurvival AnalysisUp-RegulationYoung AdultConceptsPlasma renalase levelsBorderline resectable PDACRenalase levelsPDAC precursor lesionsOverall survivalPDAC tissuesTumor characteristicsResectable PDACChronic pancreatitisPrecursor lesionsNormal pancreasPancreatic ductal adenocarcinoma growthAdvanced tumor characteristicsVaried clinical stagesWorse tumor characteristicsNode-positive diseasePancreatic ductal adenocarcinomaNormal pancreatic headSpindle-shaped cellsPlasma renalaseRenalase expressionUnderwent resectionAbdominal traumaPancreatic headPositive diseaseCheckpoint Inhibitor Colitis Shows Drug-Specific Differences in Immune Cell Reaction That Overlap With Inflammatory Bowel Disease and Predict Response to Colitis Therapy
Lo YC, Price C, Blenman K, Patil P, Zhang X, Robert ME. Checkpoint Inhibitor Colitis Shows Drug-Specific Differences in Immune Cell Reaction That Overlap With Inflammatory Bowel Disease and Predict Response to Colitis Therapy. American Journal Of Clinical Pathology 2021, 156: 214-228. PMID: 33555016, DOI: 10.1093/ajcp/aqaa217.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseCD8/FOXP3 ratioBiopsy specimensCPI patientsPD-1CD68 scoreFOXP3 ratioBowel diseasePD-L1Antibody-treated patientsCheckpoint inhibitor colitisPD-L1 groupInitial biopsy specimensPD-L1 expressionImmune cell reactionsColonic biopsy specimensDrug-specific differencesIBD groupCheckpoint inhibitorsChronicity scoreActivity scoreImmune phenotypeTherapeutic responseColitisShared pathophysiology
2020
Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis
Takeuchi M, Vidigal PT, Guerra MT, Hundt MA, Robert ME, Olave-Martinez M, Aoki S, Khamphaya T, Kersten R, Kruglov E, de la Rosa Rodriguez R, Banales JM, Nathanson MH, Weerachayaphorn J. Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis. Gut 2020, 70: 342-356. PMID: 33214166, PMCID: PMC7906004, DOI: 10.1136/gutjnl-2020-322540.Peer-Reviewed Original ResearchConceptsBile ductCholestatic changesLimited treatment optionsPresence of cholestasisAbility of neutrophilsLife-threatening diseaseNew therapeutic targetsHuman bile ductIntracellular calcium channelsAlcoholic hepatitisLiver biopsyControl neutrophilsPathological findingsHepatocellular damageHistological findingsTreatment optionsCell adhesion moleculeHistological parametersDisease altersITPR3 expressionTherapeutic targetAnimal modelsCalcium channelsNeutrophilsPatientsSmooth muscle tumors of the gastrointestinal tract: an analysis of prognostic features in 407 cases
Alpert L, Al-Sabti R, Graham RP, Pai RK, Gonzalez RS, Zhang X, Smith V, Wang HL, Westbrook L, Goldblum JR, Bakhshwin A, Shetty S, Klimstra DS, Shia J, Askan G, Robert ME, Thomas C, Frankel WL, Alsomali M, Hagen C, Mostafa ME, Feely MM, Assarzadegan N, Misdraji J, Shih AR, Agostini-Vulaj D, Meis JM, Tang S, Chatterjee D, Kang LI, Hart J, Lee SM, Smith T, Yantiss RK, Hissong EM, Gao ZH, Wu J, Resnick MB, Wu EY, Pai RK, Zhao L, Doyle LA, Chopra S, Panarelli NC, Hu S, Longacre TA, Raghavan SS, Lauwers GY, Ghayouri M, Cooper HS, Nagarathinam R, Bellizzi AM, Kakar S, Hosseini M, Rong J, Greenson JK, Lamps LW, Dong Z, Bronner MP. Smooth muscle tumors of the gastrointestinal tract: an analysis of prognostic features in 407 cases. Modern Pathology 2020, 33: 1410-1419. PMID: 32051556, PMCID: PMC8405135, DOI: 10.1038/s41379-020-0492-5.Peer-Reviewed Original ResearchConceptsSmooth muscle tumorsGastrointestinal smooth muscle tumorsMuscle tumorsPrognostic featuresSmall bowelGastrointestinal tractNon-progressive tumorsProgression-free survivalSlight female predominanceDisease-related deathKaplan-Meier plotsReceiver operator characteristic analysisSoft tissue pathologistsPotential prognostic featuresOperator characteristic analysisMucosal ulcerationSerosal involvementFemale predominanceLocal recurrenceMargin statusPathologic featuresTumor sizeLarge tumorsEsophageal tumorsTumor necrosis
2019
Effects of Endotoxin on Type 3 Inositol 1,4,5‐Trisphosphate Receptor in Human Cholangiocytes
Franca A, Filho A, Guerra MT, Weerachayaphorn J, dos Santos M, Njei B, Robert M, Lima C, Vidigal P, Banales JM, Ananthanarayanan M, Leite MF, Nathanson MH. Effects of Endotoxin on Type 3 Inositol 1,4,5‐Trisphosphate Receptor in Human Cholangiocytes. Hepatology 2019, 69: 817-830. PMID: 30141207, PMCID: PMC6351171, DOI: 10.1002/hep.30228.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Alcoholic hepatitisEffect of endotoxinBile duct cellsNF-κBInhibition of TLR4Human cholangiocytesStimulation of TLR4Duct cellsSevere alcoholic hepatitisCholestasis of sepsisForms of cholestasisNF-κB subunitsP65/p50Trisphosphate receptorReceptor 4Clinical conditionsBicarbonate secretionHepatocellular changesITPR3 expressionCholestasisType 3 inositolLPS receptorAgonist stimulusSepsis
2017
ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation
Rostami K, Marsh M, Johnson M, Mohaghegh H, Heal C, Holmes G, Ensari A, Aldulaimi D, Bancel B, Bassotti G, Bateman A, Becheanu G, Bozzola A, Carroccio A, Catassi C, Ciacci C, Ciobanu A, Danciu M, Derakhshan M, Elli L, Ferrero S, Fiorentino M, Fiorino M, Ganji A, Ghaffarzadehgan K, Going J, Ishaq S, Mandolesi A, Mathews S, Maxim R, Mulder C, Neefjes-Borst A, Robert M, Russo I, Rostami-Nejad M, Sidoni A, Sotoudeh M, Villanacci V, Volta U, Zali M, Srivastava A. ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation. Gut 2017, 66: 2080. PMID: 28893865, PMCID: PMC5749338, DOI: 10.1136/gutjnl-2017-314297.Peer-Reviewed Original ResearchConceptsIntraepithelial lymphocyte countsReceiver operating characteristicIntraepithelial lymphocytesCoeliac diseaseMarsh III lesionsIII lesionsHistological diagnosis of coeliac diseaseNormal controlsReceiver operating characteristic curve analysisDiagnosis of coeliac diseaseOptimal cut-off pointReceiver operating characteristic analysisOptimal cut-offCount intraepithelial lymphocytesCut-off pointCut-offHistological diagnosisLymphocyte countMulticentre studyDuodenal biopsiesAntigenic influenceCurve analysisBiopsyDose responseControl group
2015
American Gastroenterological Association Institute Technical Review on the Role of Upper Gastrointestinal Biopsy to Evaluate Dyspepsia in the Adult Patient in the Absence of Visible Mucosal Lesions
Allen J, Katzka D, Robert M, Leontiadis G. American Gastroenterological Association Institute Technical Review on the Role of Upper Gastrointestinal Biopsy to Evaluate Dyspepsia in the Adult Patient in the Absence of Visible Mucosal Lesions. Gastroenterology 2015, 149: 1088-1118. PMID: 26278504, DOI: 10.1053/j.gastro.2015.07.040.Peer-Reviewed Original Research
2005
Absence of human papillomavirus in esophageal carcinomas from southwestern Kenya
White R, Mungatana C, Mutuma G, Robert M, Daniel R, Topazian M, Shah K. Absence of human papillomavirus in esophageal carcinomas from southwestern Kenya. Diseases Of The Esophagus 2005, 18: 28-30. PMID: 15773838, DOI: 10.1111/j.1442-2050.2005.00452.x.Peer-Reviewed Original Research
2004
Patterns of Inflammation in Mucosal Biopsies of Ulcerative Colitis
Robert M, Tang L, Hao L, Reyes-Mugica M. Patterns of Inflammation in Mucosal Biopsies of Ulcerative Colitis. The American Journal Of Surgical Pathology 2004, 28: 183-189. PMID: 15043307, DOI: 10.1097/00000478-200402000-00005.Peer-Reviewed Original ResearchConceptsColonic mucosal biopsiesCrypt architectural distortionYears of ageEpithelial injuryMucosal biopsiesUlcerative colitisHistological featuresArchitectural distortionRectal biopsyCrypt abscessesPresentation of ulcerative colitisYears of follow-upInitiation of therapyPlasma cell infiltrationDiagnosis of ulcerative colitisPattern of inflammationDegree of colitisDegree of inflammationAge groupsDiagnosed ulcerative colitisPathological confirmationInitial presentationCrypt branchingNo significant differenceHistological criteria
2001
Dysplasia as a predictive marker for invasive carcinoma in Barrett esophagus: A follow-up study based on 138 cases from a diagnostic variability study
Montgomery E, Goldblum J, Greenson J, Haber M, Lamps L, Lauwers G, Lazenby A, Lewin D, Robert M, Washington K, Zahurak M, Hart J. Dysplasia as a predictive marker for invasive carcinoma in Barrett esophagus: A follow-up study based on 138 cases from a diagnostic variability study. Human Pathology 2001, 32: 379-388. PMID: 11331954, DOI: 10.1053/hupa.2001.23511.Peer-Reviewed Original ResearchConceptsHigh-grade dysplasiaLow-grade dysplasiaBarrett's esophagusInvasive carcinomaMajority diagnosisCases of HGDCases of LGDCases of BEEndoscopic biopsy specimensKaplan-Meier statisticsInitial biopsyEndoscopic surveillanceUlcerated areaGastrointestinal pathologyBiopsy specimenPredictive markerBiopsy diagnosisBiopsy specimensIntramucosal carcinomaPrecursor lesionsIND casesPowerful prognosticatorCarcinomaMorphologic evaluationUlcerated cases
2000
Granular Cells as a Marker of Early Amiodarone Hepatotoxicity
Jain D, Bowlus C, Anderson J, Robert M. Granular Cells as a Marker of Early Amiodarone Hepatotoxicity. Journal Of Clinical Gastroenterology 2000, 31: 241-243. PMID: 11034006, DOI: 10.1097/00004836-200010000-00012.Peer-Reviewed Original ResearchConceptsChronic amiodarone useGranular cellsAmiodarone useAcute hepatitisAcute administrationLiver biopsyPathologic findingsIdiosyncratic reactionsAD therapyAmiodarone hepatotoxicityGranular cytoplasmHepatotoxicityClusters of cellsHepatitisMembranous inclusionsCellsBiopsyHistologicTherapyCliniciansLiverMacrophagesAdministrationWeeksThe Histologic Spectrum and Clinical Outcome of Refractory and Unclassified Sprue
Robert M, Ament M, Weinstein W. The Histologic Spectrum and Clinical Outcome of Refractory and Unclassified Sprue. The American Journal Of Surgical Pathology 2000, 24: 676-687. PMID: 10800986, DOI: 10.1097/00000478-200005000-00006.Peer-Reviewed Original ResearchConceptsSmall bowel biopsyBowel biopsyCollagenous sprueUnclassified sprueRefractory patientsCeliac diseaseNormal duodenal biopsiesResidual mucosal abnormalityResponsive celiac diseaseSetting of malabsorptionGluten-free dietTotal parenteral nutritionGroup of patientsLong-term followB-cell lymphomaSubtle histologic changesMucosal thinningPersistent malabsorptionDuodenal biopsiesParenteral nutritionRefractory courseRefractory diseaseNonspecific findingsClinical outcomesChronic inflammation
1999
Biliary Tract Obstruction Secondary to Mycosis Fungoides: A Case Report
Madsen J, Tallini G, Glusac E, Salem R, Braverman I, Robert M. Biliary Tract Obstruction Secondary to Mycosis Fungoides: A Case Report. Journal Of Clinical Gastroenterology 1999, 28: 56-60. PMID: 9916670, DOI: 10.1097/00004836-199901000-00015.Peer-Reviewed Original ResearchConceptsExtrahepatic biliary treeMycosis fungoidesBiliary treeObstructive jaundiceCutaneous T-cell lymphomaMonoclonal T-cell populationMixed lymphocytic infiltratePrevious skin biopsiesBiliary tract obstructionT cell populationsT-cell lymphomaGene rearrangement studiesObstructive symptomsTract obstructionLiver involvementSurgical resectionIsolated involvementLymphocytic infiltrateEndoscopic examinationExtrahepatic ductsAtypical cellsCase reportSkin biopsiesFungoidesMultiple organs
1997
Characterization of afferent mechanisms in ileoanal pouches.
Bernstein C, Rollandelli R, Niazi N, Robert M, Hirsh T, Munakata J, Mayer E. Characterization of afferent mechanisms in ileoanal pouches. The American Journal Of Gastroenterology 1997, 92: 103-8. PMID: 8995947.Peer-Reviewed Original ResearchConceptsIleoanal pouchPouch complianceProximal ileumActive ulcerative colitisAnal sphincter functionAfferent nerve functionBalloon distentionIntrapouch pressureS3 dermatomesNerve functionPouch functionSphincter functionAfferent mechanismsUlcerative colitisAfferent innervationClinical featuresClinical presentationColorectal inflammationReferral patternsReflex functionReflex regulationAfferent pathwaysDistention pressuresLower volume thresholdRamp distention
1996
Small intestine transplantation at the University of California, Los Angeles.
Farmer D, Shaked A, McDiarmid S, Olthoff K, Millis J, Imagawa D, Colonna J, Robert M, Lewin K, Goldstein L, Busuttil R. Small intestine transplantation at the University of California, Los Angeles. Transplantation Proceedings 1996, 28: 2746-7. PMID: 8908036.Peer-Reviewed Original ResearchRectal afferent function in patients with inflammatory and functional intestinal disorders
Bernstein C, Niazi N, Robert M, Mertz H, Kodner A, Munakata J, Naliboff B, Mayer E. Rectal afferent function in patients with inflammatory and functional intestinal disorders. Pain 1996, 66: 151-161. PMID: 8880836, DOI: 10.1016/0304-3959(96)03062-x.Peer-Reviewed Original ResearchConceptsIrritable bowel syndromeInflammatory bowel diseaseDiarrhea-predominant irritable bowel syndromeViscerosomatic referral patternCrohn's disease patientsIBS patientsDisease patientsCrohn's diseaseMale patientsReferral patternsAfferent pathwaysReflex responsesHealthy male control subjectsTissue irritationAutonomic reflex responsesChronic ileal inflammationLower distension pressuresRapid phasic distensionDorsal horn neuronsVisceral afferent pathwaysIleal Crohn's diseaseFunctional intestinal disordersMale control subjectsSkin conductance responsesBulbospinal inhibitionCarcinoid tumor of the common bile duct producing gastrin and serotonin.
Hao L, Friedman A, Navarro V, West B, Robert M. Carcinoid tumor of the common bile duct producing gastrin and serotonin. Journal Of Clinical Gastroenterology 1996, 23: 63-5. PMID: 8835905, DOI: 10.1097/00004836-199607000-00018.Peer-Reviewed Original Research
1994
Pancreatitis Associated with Adult Choledochal Cysts
Swisher S, Cates J, Hunt K, Robert M, Bennion R, Thompson J, Roslyn J, Reber H. Pancreatitis Associated with Adult Choledochal Cysts. Pancreas 1994, 9: 633-637. PMID: 7809018, DOI: 10.1097/00006676-199409000-00014.Peer-Reviewed Original ResearchConceptsEndoscopic retrograde cholangiopancreatographyCholedochal cystElevated serum amylase levelsTreated with surgical resectionAbnormal pancreaticobiliary junctionAdult choledochal cystsLoss of surface epitheliumEpisodes of pancreatitisPancreatic duct anatomyRate of pancreatitisSerum amylase levelsPancreatic inflammatory diseaseFocal chronic inflammationEpigastric painSurgical resectionPancreatic headPancreaticobiliary junctionProlonged coursePancreatic phlegmonChronic pancreatitisRetrograde cholangiopancreatographyAmylase levelsPancreatic abscessAdult patientsSurgical bypass