2020
Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis
Takeuchi M, Vidigal PT, Guerra MT, Hundt MA, Robert ME, Olave-Martinez M, Aoki S, Khamphaya T, Kersten R, Kruglov E, de la Rosa Rodriguez R, Banales JM, Nathanson MH, Weerachayaphorn J. Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis. Gut 2020, 70: 342-356. PMID: 33214166, PMCID: PMC7906004, DOI: 10.1136/gutjnl-2020-322540.Peer-Reviewed Original ResearchConceptsBile ductCholestatic changesLimited treatment optionsPresence of cholestasisAbility of neutrophilsLife-threatening diseaseNew therapeutic targetsHuman bile ductIntracellular calcium channelsAlcoholic hepatitisLiver biopsyControl neutrophilsPathological findingsHepatocellular damageHistological findingsTreatment optionsCell adhesion moleculeHistological parametersDisease altersITPR3 expressionTherapeutic targetAnimal modelsCalcium channelsNeutrophilsPatients
1992
Familial pulmonary nodular lymphoid hyperplasia
Franchi L, Chin T, Nussbaum E, Riker J, Robert M, Talbert W. Familial pulmonary nodular lymphoid hyperplasia. The Journal Of Pediatrics 1992, 121: 89-92. PMID: 1625100, DOI: 10.1016/s0022-3476(05)82550-8.Peer-Reviewed Original ResearchConceptsSystemic autoimmune disorderHyperplastic lymphoid folliclesElevated immunoglobulin levelsPulmonary compromiseAntinuclear antibodiesAutoimmune disordersChronic hypoxiaDigital clubbingPathological findingsLymphoid folliclesImmunoglobulin levelsSmall airwaysAirwayPatientsEpitheliumFolliclesHypoxiaAntibodies