2021
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice
Mao T, Israelow B, Lucas C, Vogels CBF, Gomez-Calvo ML, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M, Alpert T, Anderson F, Earnest R, Fauver J, Kalinich C, Munyenyembe K, Ott I, Petrone M, Rothman J, Watkins A, Wilen C, Landry M, Grubaugh N, Pyle A, Iwasaki A. A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice. Journal Of Experimental Medicine 2021, 219: e20211818. PMID: 34757384, PMCID: PMC8590200, DOI: 10.1084/jem.20211818.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntiviral AgentsCOVID-19COVID-19 Drug TreatmentDisease Models, AnimalImmunity, InnateInterferon Type IMiceMice, Inbred BALB CRNASARS-CoV-2ConceptsSARS-CoV-2 infectionChronic SARS-CoV-2 infectionVariants of concernLethal SARS-CoV-2 infectionPost-infection therapyLower respiratory tractPost-exposure treatmentType I interferonSARS-CoV-2Effective medical countermeasuresAdaptive immune systemBroad-spectrum antiviralsContext of infectionSingle doseRespiratory tractViral controlImmunodeficient miceSevere diseaseMouse modelI interferonViral infectionImmune systemInnate immunityDisease preventionConsiderable efficacy
1996
Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness.
Einarsson O, Geba G, Zhu Z, Landry M, Elias J. Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness. Journal Of Clinical Investigation 1996, 97: 915-924. PMID: 8613544, PMCID: PMC507136, DOI: 10.1172/jci118514.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusIL-11 productionParainfluenza virus type 3Airway hyperresponsivenessIL-11Viral upper respiratory tract infectionUpper respiratory tract infectionBALB/c miceSimplex virus type 2Viral-induced asthmaViral respiratory infectionsRespiratory tract infectionsNonspecific airway hyperresponsivenessVirus type 2Virus type 3Clinical bronchospasmAirway dysfunctionAirway physiologyTract infectionsRespiratory infectionsRespiratory virusesSyncytial virusC miceNasal aspiratesViral infection
1995
Interleukin‐11 in Respiratory Inflammation
EINARSSON O, GEBA GP, ZHOU Z, LANDRY ML, PANETTIERI RA, TRISTRAM D, WELLIVER R, METINKO A, ELIAS JA. Interleukin‐11 in Respiratory Inflammation. Annals Of The New York Academy Of Sciences 1995, 762: 89-101. PMID: 7668577, DOI: 10.1111/j.1749-6632.1995.tb32317.x.Peer-Reviewed Original ResearchAsthma-Associated Viruses Specifically Induce Lung Stromal Cells to Produce Interleukin-11, a Mediator of Airways Hyperreactivity
Einarsson O, Geba G, Panuska J, Zhu Z, Landry M, Elias J. Asthma-Associated Viruses Specifically Induce Lung Stromal Cells to Produce Interleukin-11, a Mediator of Airways Hyperreactivity. CHEST Journal 1995, 107: 132s-133s. PMID: 7874994, DOI: 10.1378/chest.107.3_supplement.132s.Peer-Reviewed Original Research