2021
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics
Cheemarla NR, Watkins TA, Mihaylova VT, Wang B, Zhao D, Wang G, Landry ML, Foxman EF. Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics. Journal Of Experimental Medicine 2021, 218: e20210583. PMID: 34128960, PMCID: PMC8210587, DOI: 10.1084/jem.20210583.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngiotensin-Converting Enzyme 2Case-Control StudiesChemokine CXCL10COVID-19Disease SusceptibilityFemaleGene Expression ProfilingHost-Pathogen InteractionsHumansImmunity, InnateInterferonsMaleMiddle AgedNasopharynxPicornaviridae InfectionsSARS-CoV-2Viral LoadVirus ReplicationConceptsSARS-CoV-2 infectionSARS-CoV-2 exposureSARS-CoV-2Interferon-stimulated genesUpper respiratory tractRespiratory tractEarly SARS-CoV-2 infectionDynamic innate immune responseViral replicationSARS-CoV-2 replicationPatient nasopharyngeal samplesInnate immune responseLow infectious doseViral loadNasopharyngeal samplesImmune responseInfectious doseISG responseAntiviral responseInfection progressionViral transmissionLevel correlatesInfectionISG inductionInitial replication
2010
The Molecular Diagnosis of Parechovirus Infection: Has the Time Come?
Landry ML. The Molecular Diagnosis of Parechovirus Infection: Has the Time Come? Clinical Infectious Diseases 2010, 50: 362-363. PMID: 20047495, DOI: 10.1086/649864.Peer-Reviewed Original ResearchAutopsyClinical Laboratory TechniquesHumansInfantMolecular Diagnostic TechniquesParechovirusPicornaviridae Infections
2009
Rhinoviruses Are a Major Cause of Wheezing and Hospitalization in Children Less Than 2 Years of Age
Piotrowska Z, Vázquez M, Shapiro ED, Weibel C, Ferguson D, Landry ML, Kahn JS. Rhinoviruses Are a Major Cause of Wheezing and Hospitalization in Children Less Than 2 Years of Age. The Pediatric Infectious Disease Journal 2009, 28: 25-29. PMID: 19057454, PMCID: PMC4639321, DOI: 10.1097/inf.0b013e3181861da0.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusHRV-positive childrenHuman rhinovirusSyncytial virusAge groupsDiagnostic laboratoriesRespiratory tract diseaseMajor respiratory pathogenRate of infectionYears of ageSimilar age groupAsymptomatic childrenRespiratory specimenAsymptomatic groupRespiratory infectionsHRV infectionHospitalization ratesPolymerase chain reactionTract diseaseRespiratory pathogensHRV isolatesMajor causeStudy periodSymptomsInfection
1996
Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation.
Zhu Z, Tang W, Ray A, Wu Y, Einarsson O, Landry ML, Gwaltney J, Elias JA. Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation. Journal Of Clinical Investigation 1996, 97: 421-430. PMID: 8567963, PMCID: PMC507033, DOI: 10.1172/jci118431.Peer-Reviewed Original ResearchConceptsIL-6 productionIL-6RV infectionPotent stimulatorIL-6 protein productionIL-6 siteSymptomatic RV infectionsNuclear factor kappa BFactor kappa BIL-6 mRNA accumulationNF-kappa B activationNF-kappa B DNA binding activityPromoter-driven luciferase activityRhinovirus stimulationRV challengeNF-kappa BNF-kappa B siteInterleukin-6Nasal washingsKappa BSymptomatic volunteersRhinovirusStimulation pathwayNuclear factorB activation