2021
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice
Mao T, Israelow B, Lucas C, Vogels CBF, Gomez-Calvo ML, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M, Alpert T, Anderson F, Earnest R, Fauver J, Kalinich C, Munyenyembe K, Ott I, Petrone M, Rothman J, Watkins A, Wilen C, Landry M, Grubaugh N, Pyle A, Iwasaki A. A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice. Journal Of Experimental Medicine 2021, 219: e20211818. PMID: 34757384, PMCID: PMC8590200, DOI: 10.1084/jem.20211818.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionChronic SARS-CoV-2 infectionVariants of concernLethal SARS-CoV-2 infectionPost-infection therapyLower respiratory tractPost-exposure treatmentType I interferonSARS-CoV-2Effective medical countermeasuresAdaptive immune systemBroad-spectrum antiviralsContext of infectionSingle doseRespiratory tractViral controlImmunodeficient miceSevere diseaseMouse modelI interferonViral infectionImmune systemInnate immunityDisease preventionConsiderable efficacy
2016
Parvovirus B19
Landry ML. Parvovirus B19. Microbiology Spectrum 2016, 4: 10.1128/microbiolspec.dmih2-0008-2015. PMID: 27337440, DOI: 10.1128/microbiolspec.dmih2-0008-2015.Peer-Reviewed Original ResearchConceptsParvovirus B19 infectionIntravenous immunoglobulinB19 infectionIgG antibodiesImmune systemActive parvovirus B19 infectionPrimary parvovirus B19 infectionPure red cell aplasiaMaintenance intravenous immunoglobulinRed cell transfusionSufficient immune responsePatient's immune systemRed cell aplasiaReal-time polymerase chain reaction methodRed cell precursorsB19 variantsGiant pronormoblastsRecurrent anemiaB19 IgMChronic anemiaPolymerase chain reaction methodSevere anemiaTherapeutic optionsPrimary infectionParvovirus B19