Marie-Louise Landry, MD
Professor of Laboratory Medicine and of Medicine (Infectious Diseases)Cards
Additional Titles
Vice Chair for Quality and Safety, Laboratory Medicine
Director, Clinical Virology Laboratory
Publications Overview
- 187 Publications
- 8,322 Citations
- 70 Yale Co-Authors
Clinical Virology Laboratory
Additional Titles
Vice Chair for Quality and Safety, Laboratory Medicine
Director, Clinical Virology Laboratory
Publications Overview
- 187 Publications
- 8,322 Citations
- 70 Yale Co-Authors
Clinical Virology Laboratory
Additional Titles
Vice Chair for Quality and Safety, Laboratory Medicine
Director, Clinical Virology Laboratory
Publications Overview
- 187 Publications
- 8,322 Citations
- 70 Yale Co-Authors
Clinical Virology Laboratory
About
Titles
Professor of Laboratory Medicine and of Medicine (Infectious Diseases)
Vice Chair for Quality and Safety, Laboratory Medicine; Director, Clinical Virology Laboratory
Biography
Dr. Landry graduated from Georgetown University School of Medicine, received her internal medicine residency training at Yale New Haven Hospital, and completed fellowships in Infectious Diseases and Clinical Virology (Laboratory Medicine) at Yale University. She is board certified in Internal Medicine and Infectious Diseases but has focused her career on the field of diagnostic virology.
Under Dr. G.D. Hsiung, she helped to establish the national Virology Reference Laboratory at VA Connecticut, and subsequently established the Clinical Virology Laboratory within the Department of Laboratory Medicine at Yale New Haven Hospital, one of the premier virology laboratories in the U.S. She has over 200 publications on diagnostic testing, and has been the Virology Volume Editor for the Manual of Clinical Microbiology from ASM Press from the 9th to the 13th edition and is Co-Editor in Chief for the 14th edition. She serves as the main teacher of Medical Virology for Yale medical students, and as Vice Chair for Quality and Safety Laboratory Medicine.
Dr. Landry’s interests focus on the rapid detection and quantitation of viruses for clinical diagnosis and the impact of new test methods on patient management.
Appointments
Laboratory Medicine
ProfessorPrimaryInfectious Diseases
ProfessorSecondary
Other Departments & Organizations
Education & Training
- Fellow
- Yale University School of Medicine (1981)
- Fellow
- Yale University School of Medicine (1979)
- Resident
- Yale-New Haven Hospital (1977)
- MD
- Georgetown University (1974)
Research
Overview
Medical Subject Headings (MeSH)
ORCID
0000-0001-5543-8366- View Lab Website
Clinical Virology Laboratory
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
David Ferguson
Chantal Vogels, PhD
Nathan Grubaugh, PhD
Chaney Kalinich, MPH
Ellen F Foxman, MD, PhD
Marwan Mikheal Azar, MD, FAST, FIDSA
Virus Diseases
Respiratory Tract Diseases
Diagnostic Techniques and Procedures
Prognosis
Publications
2024
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children
Watkins T, Green A, Amat J, Cheemarla N, Hänsel K, Lozano R, Dudgeon S, Germain G, Landry M, Schulz W, Foxman E. High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children. Journal Of Experimental Medicine 2024, 221: e20230911. PMID: 38949638, PMCID: PMC11215523, DOI: 10.1084/jem.20230911.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBacterial pathobiontsRespiratory virusesBurden of virusesSARS-CoV-2Innate immune activationSARS-CoV-2 viral loadDynamic host-pathogen interactionsInnate immune responseViral coinfectionCytokine profileViral loadNasal virusImmune activationProinflammatory responseIL-1BNasopharyngeal samplesHost-pathogen interactionsImmune responseInterferon responsePathobiontsInnate immunityPaired samplesCXCL10Healthy 1-year-oldVirusPerformance of two modified two-tier algorithms for the serologic diagnosis of Lyme disease
Landry M, Hassan S, Rottmann B, Pesak S, Ordazzo M, Skrzyniarz M, Deponte S, Peaper D. Performance of two modified two-tier algorithms for the serologic diagnosis of Lyme disease. Journal Of Clinical Microbiology 2024, 62: e00139-24. PMID: 38597655, PMCID: PMC11077974, DOI: 10.1128/jcm.00139-24.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPositive percent agreementSerologic diagnosis of Lyme diseaseDiagnosis of Lyme diseaseEnzyme-linked immunoassayBorrelia speciesTwo-tier algorithmLyme diseaseTwo-tier testImmunoblottingLaboratory diagnosis of Lyme diseaseLIAISON chemiluminescent immunoassaysChemiluminescence immunoassayDetection of IgMScreening testConsensus reference standardSerological diagnosisLaboratory diagnosisDiaSorinIgM resultsIgM detection
2023
Progressive shingles in a toddler due to reactivation of Varicella Zoster vaccine virus four days after infection with SARS-CoV-2; a case report
Miller C, Taylor-Salmon E, Emuren L, Landry M, Gershon A, Miller G. Progressive shingles in a toddler due to reactivation of Varicella Zoster vaccine virus four days after infection with SARS-CoV-2; a case report. BMC Infectious Diseases 2023, 23: 854. PMID: 38057696, PMCID: PMC10698951, DOI: 10.1186/s12879-023-08809-5.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVaricella-zoster virusVZV reactivationVaccine-strain varicella-zoster virusSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Latent varicella zoster virusSymptomatic COVID-19 infectionRespiratory syndrome coronavirus 2SARS-CoV2 infectionSyndrome coronavirus 2COVID-19 infectionVaccine-type strainsSARS-CoV-2Vesicular rashPediatric patientsSignificant morbidityClinical syndromeCoronavirus 2Single doseCase reportGeneral populationMechanical traumaDisease processHZ casesPhysiologic stressLymphocytic Choriomeningitis Virus in Person Living with HIV, Connecticut, USA, 2021 - Volume 29, Number 9—September 2023 - Emerging Infectious Diseases journal - CDC
Dyal J, Gandhi S, Cossaboom C, Leach A, Patel K, Golden M, Canterino J, Landry M, Cannon D, Choi M, Krapiunaya I, Klena J, Shoemaker T. Lymphocytic Choriomeningitis Virus in Person Living with HIV, Connecticut, USA, 2021 - Volume 29, Number 9—September 2023 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2023, 29: 1886-1889. PMID: 37610188, PMCID: PMC10461659, DOI: 10.3201/eid2909.230087.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsLymphocytic Choriomeningitis Virus in Person Living with HIV, Connecticut, USA, 2021
Dyal J, Gandhi S, Cossaboom C, Leach A, Patel K, Golden M, Canterino J, Landry M, Cannon D, Choi M, Krapiunaya I, Klena J, Shoemaker T. Lymphocytic Choriomeningitis Virus in Person Living with HIV, Connecticut, USA, 2021. Emerging Infectious Diseases 2023, 29 DOI: 10.3201/2909.230087.Peer-Reviewed Original ResearchFailure to Detect Influenza A H1N1 Highlights the Need for Multiple Gene Targets in Influenza Molecular Tests
Landry M, Owen M. Failure to Detect Influenza A H1N1 Highlights the Need for Multiple Gene Targets in Influenza Molecular Tests. Journal Of Clinical Microbiology 2023, 61: e00448-23. PMID: 37338345, PMCID: PMC10358165, DOI: 10.1128/jcm.00448-23.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsEnhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants
Moriyama M, Lucas C, Monteiro V, Initiative Y, Iwasaki A, Chen N, Breban M, Hahn A, Pham K, Koch T, Chaguza C, Tikhonova I, Castaldi C, Mane S, De Kumar B, Ferguson D, Kerantzas N, Peaper D, Landry M, Schulz W, Vogels C, Grubaugh N. Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2221652120. PMID: 37036977, PMCID: PMC10120007, DOI: 10.1073/pnas.2221652120.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMHC-I expressionBreakthrough infectionsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variantsMajor histocompatibility complex class I expressionCell-mediated immunityInfluenza virus infectionSARS-CoV-2 VOCsMHC-I upregulationClass I expressionSARS-CoV-2T cell recognitionVirus infectionMHC II expressionSpike proteinEnhanced inhibitionInfectionCell recognitionCommon mutationsReinfectionE proteinAntibodiesViral genesSubvariantsExpressionNasal host response-based screening for undiagnosed respiratory viruses: a pathogen surveillance and detection study
Cheemarla N, Hanron A, Fauver J, Bishai J, Watkins T, Brito A, Zhao D, Alpert T, Vogels C, Ko A, Schulz W, Landry M, Grubaugh N, van Dijk D, Foxman E. Nasal host response-based screening for undiagnosed respiratory viruses: a pathogen surveillance and detection study. The Lancet Microbe 2023, 4: e38-e46. PMID: 36586415, PMCID: PMC9835789, DOI: 10.1016/s2666-5247(22)00296-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRespiratory virus panelPg/mLCXCL10 concentrationsSARS-CoV-2Bacterial pathobiontsRespiratory virusesSARS-CoV-2 negative samplesViral respiratory infectionsSARS-CoV-2 positive samplesClinical virology laboratoryHealth care systemVirus-positive samplesQuantitative RT-PCRInfluenza C virusSymptomatic patientsRespiratory infectionsSeasonal coronavirusesNasopharyngeal swabsVirus panelC virusCommon virusesCXCL10Host responseInterferon responseVirology laboratory
2022
Combining genomic and epidemiological data to compare the transmissibility of SARS-CoV-2 variants Alpha and Iota
Petrone ME, Rothman JE, Breban MI, Ott IM, Russell A, Lasek-Nesselquist E, Badr H, Kelly K, Omerza G, Renzette N, Watkins AE, Kalinich CC, Alpert T, Brito AF, Earnest R, Tikhonova IR, Castaldi C, Kelly JP, Shudt M, Plitnick J, Schneider E, Murphy S, Neal C, Laszlo E, Altajar A, Pearson C, Muyombwe A, Downing R, Razeq J, Niccolai L, Wilson MS, Anderson ML, Wang J, Liu C, Hui P, Mane S, Taylor BP, Hanage WP, Landry ML, Peaper DR, Bilguvar K, Fauver JR, Vogels CBF, Gardner LM, Pitzer VE, St. George K, Adams MD, Grubaugh ND. Combining genomic and epidemiological data to compare the transmissibility of SARS-CoV-2 variants Alpha and Iota. Communications Biology 2022, 5: 439. PMID: 35545661, PMCID: PMC9095641, DOI: 10.1038/s42003-022-03347-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsRapid emergence of SARS-CoV-2 Omicron variant is associated with an infection advantage over Delta in vaccinated persons
Chaguza C, Coppi A, Earnest R, Ferguson D, Kerantzas N, Warner F, Young HP, Breban MI, Billig K, Koch RT, Pham K, Kalinich CC, Ott IM, Fauver JR, Hahn AM, Tikhonova IR, Castaldi C, De Kumar B, Pettker CM, Warren JL, Weinberger DM, Landry ML, Peaper DR, Schulz W, Vogels CBF, Grubaugh ND. Rapid emergence of SARS-CoV-2 Omicron variant is associated with an infection advantage over Delta in vaccinated persons. Med 2022, 3: 325-334.e4. PMID: 35399324, PMCID: PMC8983481, DOI: 10.1016/j.medj.2022.03.010.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSpike gene target failureSARS-CoV-2 Omicron variantPositivity rateOmicron variantOmicron infectionVaccine dosesVaccine-induced immunityNumber of dosesTest positivity rateOdds of infectionSARS-CoV-2Significant reductionDominant Delta variantUnvaccinated personsVaccination statusHigher oddsDelta variantInfectionVaccine manufacturersDisease controlVirus copiesDosesPCR testOddsTarget failure
Academic Achievements & Community Involvement
honor Outstanding Teacher
Yale School of Medicine AwardYale Laboratory Medicine ResidentsDetails06/12/2020United Stateshonor Distinguished Clinical Career Award
Yale School of Medicine AwardYale MedicineDetails05/04/2020United Stateshonor Lab Week Hero Award
National AwardClinical Laboratory Standards InstituteDetails04/29/2020United Stateshonor Outstanding Teacher
Yale School of Medicine AwardYale Pathology and Laboratory Medicine ResidentsDetails06/30/2012United Stateshonor Bohmfalk Teaching Prize, Outstanding Teacher of the Basic Sciences
Yale School of Medicine AwardYale University School of MedicineDetails05/31/2005United States
Clinical Care
Overview
When she thought about what she’d like to do as a doctor, Marie Louise Landry, MD, originally intended to care for patients in the developing world. Instead she ended up in the lab, diagnosing viral diseases. “I meant only to learn about viruses to inform my infectious disease training, not make virology the focus of my career, but the need and opportunity presented themselves,” Dr. Landry says.
Dr. Landry is board-certified in internal medicine and infectious diseases, but has focused most of her work on the burgeoning field of diagnosing and detecting viruses. She enjoys working in a field where things are always changing and the pace is ever faster. “When I started in virology, tests could take weeks to complete, there were no treatments and the laboratory phone never rang. Now we have clinicians calling all day and even in the middle of the night wanting virology tests,” Dr. Landry says.
Dr. Landry is a professor of laboratory medicine and of infectious disease medicine at Yale School of Medicine.
Clinical Specialties
Board Certifications
Infectious Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1982
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1977
Yale Medicine News
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileNews
News
- July 01, 2024Source: Channel 8 news
Why did so few children get sick from COVID-19?
- June 14, 2024Source: American Society for Microbiology
Podcast: To Catch a Virus Second Edition Explores the Gripping History of Viral Epidemics
- June 14, 2024Source: Emerging Infectious Diseases
Book Review: To Catch A Virus, 2nd Ed.
- February 06, 2024
The FDA’s Proposed Ruling on Lab Tests Could Have Unintended Consequences
Get In Touch
Contacts
Laboratory Medicine
PO Box 208035, 333 Cedar Street
New Haven, CT 06520-8035
United States
Locations
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.