Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
Lei Y, VanPortfliet J, Chen Y, Bryant J, Li Y, Fails D, Torres-Odio S, Ragan K, Deng J, Mohan A, Wang B, Brahms O, Yates S, Spencer M, Tong C, Bosenberg M, West L, Shadel G, Shutt T, Upton J, Li P, West A. Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity. Cell 2023, 186: 3013-3032.e22. PMID: 37352855, PMCID: PMC10330843, DOI: 10.1016/j.cell.2023.05.039.Peer-Reviewed Original ResearchAnimalsCardiotoxicityDNA, MitochondrialImmunity, InnateInterferonsMiceNucleotidyltransferasesPhosphorylation