2016
Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics
Yoder K, Albrecht D, Dzemidzic M, Normandin M, Federici L, Graves T, Herring C, Hile K, Walters J, Liang T, Plawecki M, O'Connor S, Kareken D. Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics. Drug And Alcohol Dependence 2016, 160: 163-169. PMID: 26832934, PMCID: PMC5074339, DOI: 10.1016/j.drugalcdep.2016.01.001.Peer-Reviewed Original ResearchConceptsSample of social drinkersNontreatment-seeking alcoholicsSocial drinkersVentral striatumDopamine releaseAlcohol intoxicationAlcohol-induced dopamine releaseVoxel-wise binding potentialTarget breath alcohol concentrationEffects of alcohol intoxicationRight ventral striatumInduce dopamine releaseStriatal DA systemIntravenous alcohol infusionAlcohol use disorderResponse to alcoholBreath alcohol concentrationDA responseStriatal dopamineDA systemTarget BrACAlcohol clampUse disorderDependent drinkersAlcohol infusion
2013
Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI
Sander C, Hooker J, Catana C, Normandin M, Alpert N, Knudsen G, Vanduffel W, Rosen B, Mandeville J. Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 11169-11174. PMID: 23723346, PMCID: PMC3703969, DOI: 10.1073/pnas.1220512110.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingDopamine receptor occupancyReceptor occupancyPositron emission tomographyFunctional magnetic resonance imaging measuresDose of racloprideBasal dopamine levelsDopamine-rich striatumInvestigation of neurovascular couplingDomains of spaceAnesthetized nonhuman primatesSimultaneous PET/fMRIDopamine levelsBrain activitySimultaneous neuroimagingBinding potentialBasal gangliaReceptor systemNonhuman primatesPositron emission tomography tracersMagnetic resonance imagingLiterature differencesEmission tomographyMap associationsNeurovascular coupling