2023
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
2022
Prevalence and treatment of postobstructive pneumonia among older adults with advanced cancer
Lee S, O’Donovan L, Cohen A, Gautam S, Quagliarello V, Juthani-Mehta M, Datta R. Prevalence and treatment of postobstructive pneumonia among older adults with advanced cancer. Antimicrobial Stewardship & Healthcare Epidemiology 2022, 2: e152. PMID: 36483405, PMCID: PMC9726473, DOI: 10.1017/ash.2022.293.Peer-Reviewed Original Research
2020
Education needed to improve antimicrobial use during end-of-life care of older adults with advanced cancer: A cross-sectional survey
Datta R, Topal J, McManus D, Sanft T, Dembry LM, Morrison LJ, Quagliarello V, Juthani-Mehta M. Education needed to improve antimicrobial use during end-of-life care of older adults with advanced cancer: A cross-sectional survey. Palliative Medicine 2020, 35: 236-241. PMID: 32928066, DOI: 10.1177/0269216320956811.Peer-Reviewed Original ResearchConceptsEscalation of careAdvance care planningLife careAdvanced cancerCross-sectional surveyIntravenous antimicrobialsOlder adultsAntimicrobial useCare planningSingle-center cross-sectional surveyEducational interventionAdvance care plansRole of antimicrobialsClinical deteriorationPercent of respondentsAdverse eventsOral antimicrobialsMedicine subspecialistsCare plansInpatient medicineCareCancerPatientsAdultsSubspecialistsInconsistent Addiction Treatment for Patients Undergoing Cardiac Surgery for Injection Drug Use-associated Infective Endocarditis.
Nguemeni Tiako MJ, Hong S, Bin Mahmood SU, Mori M, Mangi A, Yun J, Juthani-Mehta M, Geirsson A. Inconsistent Addiction Treatment for Patients Undergoing Cardiac Surgery for Injection Drug Use-associated Infective Endocarditis. Journal Of Addiction Medicine 2020, 14: e350-e354. PMID: 32732685, DOI: 10.1097/adm.0000000000000710.Peer-Reviewed Original ResearchConceptsActive drug useInjection drug use-associated infective endocarditisOpioid use disorderPsychosocial consultationAddiction treatmentDrug rehabilitation programInfective endocarditisRehabilitation programUse disordersDrug use-associated infective endocarditisDrug useEvidence of enrollmentTertiary care centerInjection drug useUS opioid epidemicDrug rehabilitationRehabilitation attendanceMost patientsCardiac surgeryRetrospective reviewCare centerOpioid epidemicPatientsMedicationsIDUsRepurposing antimicrobial stewardship tools in the electronic medical record for the management of COVID-19 patients
Davis MW, McManus D, Koff A, Jaszczur GR, Malinis M, Dela Cruz C, Britto CJ, Price C, Azmy V, Kaman K, Gaston D, Early K, DeWitt M, Song JS, Ortiz C, Juthani-Mehta M, Topal JE. Repurposing antimicrobial stewardship tools in the electronic medical record for the management of COVID-19 patients. Infection Control And Hospital Epidemiology 2020, 41: 1335-1337. PMID: 32507113, PMCID: PMC7308631, DOI: 10.1017/ice.2020.281.Peer-Reviewed Original Research
2019
Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures
Datta R, Zhu M, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures. American Journal Of Hospice And Palliative Medicine® 2019, 37: 27-33. PMID: 31185722, PMCID: PMC6868290, DOI: 10.1177/1049909119855617.Peer-Reviewed Original ResearchConceptsAdvanced cancerAntibiotic useComfort measuresPoisson regression modelsInfection diagnosisIntensive care unit admissionMultivariable Poisson regression modelsCare unit admissionCohort of patientsUrinary tract infectionGoal-concordant careUnit admissionEnd of lifeHospital lengthOlder patientsTract infectionsLonger LOSMedian ageRegression modelsStay AssociatedAntibiotic exposureLiquid tumorsPatientsCancerCancer typesAntimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfectionDesign and analysis of longitudinal trials of antimicrobial use at the end of life: to give or not to give?
Juthani-Mehta M, Allore HG. Design and analysis of longitudinal trials of antimicrobial use at the end of life: to give or not to give? Therapeutic Advances In Drug Safety 2019, 10: 2042098618820210. PMID: 30800269, PMCID: PMC6378640, DOI: 10.1177/2042098618820210.Peer-Reviewed Original ResearchTerminal cancer patientsAntimicrobial useEnd of lifePalliative careCancer patientsLongitudinal trialBurden of medicationsCessation of medicationHealth literacy interventionsAntimicrobial therapyAntimicrobial prescribingHealth literacyTrial designComparative trial designTrial dataTrial periodMedicationsPatientsTrialsCareLongitudinal modelingLiteracy interventionsPrescribingTherapyInfection
2018
Long-Acting Lipoglycopeptides for Gram-Positive Bacteremia at the End of Life to Facilitate Hospice Care: A Report of 3 Cases
Datta R, McManus D, Topal J, Juthani-Mehta M. Long-Acting Lipoglycopeptides for Gram-Positive Bacteremia at the End of Life to Facilitate Hospice Care: A Report of 3 Cases. Open Forum Infectious Diseases 2018, 5: ofx277. PMID: 29399598, PMCID: PMC5788065, DOI: 10.1093/ofid/ofx277.Peer-Reviewed Original Research
2017
Antimicrobial Use at the End of Life
Baghban A, Juthani-Mehta M. Antimicrobial Use at the End of Life. Infectious Disease Clinics Of North America 2017, 31: 639-647. PMID: 29079153, DOI: 10.1016/j.idc.2017.07.009.Peer-Reviewed Original ResearchBurden and Management of Multidrug-Resistant Organisms in Palliative Care
Datta R, Juthani-Mehta M. Burden and Management of Multidrug-Resistant Organisms in Palliative Care. Palliative Care And Social Practice 2017, 10: 1178224217749233. PMID: 29317826, PMCID: PMC5753884, DOI: 10.1177/1178224217749233.Peer-Reviewed Original ResearchMultidrug-resistant organismsPalliative careTerminal illnessGoals of palliationPalliative care patientsPalliative care settingAvailable treatment optionsInfection prevention measuresQuality of lifeCommon complicationContact precautionsMetastatic diseaseCare patientsPatient isolationTreatment optionsSymptom assessmentCare discussionsAntimicrobial therapyCommon signsCare settingsCognitive impairmentPsychological burdenPatientsInfectionAdverse effects
2016
Research Methods in Healthcare Epidemiology and Antimicrobial Stewardship: Randomized Controlled Trials
Anderson DJ, Juthani-Mehta M, Morgan DJ. Research Methods in Healthcare Epidemiology and Antimicrobial Stewardship: Randomized Controlled Trials. Infection Control And Hospital Epidemiology 2016, 37: 629-634. PMID: 27108848, PMCID: PMC8662919, DOI: 10.1017/ice.2016.93.Peer-Reviewed Original ResearchConceptsHealthcare EpidemiologyInfect Control Hosp EpidemiolUse of patientBehavior modification interventionKey RCTsControlled TrialsClinical evidenceAntimicrobial stewardshipOutcome selectionModification interventionsCluster randomizationRCTsAppropriate outcomesEpidemiologyTrialsRCT methodInterventionRandomizationMultiple sitesSpecific considerationsPatients
2014
Apical Pneumocystis jiroveci as an AIDS defining illness: A case report illustrating a change in the paradigm.
Pfeifer K, Kalra V, Adebowale A, Juthani-Mehta M, Soo-Shin M. Apical Pneumocystis jiroveci as an AIDS defining illness: A case report illustrating a change in the paradigm. Journal Of Radiology Case Reports 2014, 8: 15-24. PMID: 25926907, PMCID: PMC4394979, DOI: 10.3941/jrcr.v8i11.1772.Peer-Reviewed Original ResearchConceptsPneumocystis jiroveci pneumoniaImmune deficiency syndromeJiroveci pneumoniaDeficiency syndromeAIDS defining illnessGround-glass opacitiesYear old maleMore patientsCase reportUnusual presentationChest radiographsCystic spacesRelative sparingPneumoniaSyndromeIllnessPatientsLungRadiographsSparingPneumocystis
2013
Should antibiotic prophylaxis after urinary catheter removal be standard practice?
Juthani-Mehta M. Should antibiotic prophylaxis after urinary catheter removal be standard practice? The BMJ 2013, 346: f3938. PMID: 23794157, DOI: 10.1136/bmj.f3938.Peer-Reviewed Original Research
2004
Prognostic Scoring Systems for Infectious Diseases: Their Applicability to the Care of Older Adults
High K, Juthani-Mehta M, Quagliarello V. Prognostic Scoring Systems for Infectious Diseases: Their Applicability to the Care of Older Adults. Clinical Infectious Diseases 2004, 38: 692-696. PMID: 14986254, DOI: 10.1086/381688.Peer-Reviewed Original ResearchConceptsPrognostic scoring systemOlder adultsScoring systemAdult populationInfectious diseasesPrimary end pointNumber of patientsGeneral adult populationHealth care needsHealth care costsHeterogeneous adult populationClinical outcomesBloodstream infectionsIndividual patientsCare needsCare costsRelevant outcomesEnd pointClinical predictionDiseasePatientsAdultsFurther investigationCareOutcomes