2022
Molecular determinants of complexin clamping and activation function
Bera M, Ramakrishnan S, Coleman J, Krishnakumar SS, Rothman JE. Molecular determinants of complexin clamping and activation function. ELife 2022, 11: e71938. PMID: 35442188, PMCID: PMC9020821, DOI: 10.7554/elife.71938.Peer-Reviewed Original ResearchConceptsSynaptotagmin-1Single-vesicle fusionAccessory helixFusion clampHelical domainMolecular detailsComplexinMutational analysisVesicle releaseFusion kineticsMolecular determinantsSpecific interactionsInhibitory functionProbability of fusionRapid CaSNAREpinsAssembly processFusionClamping functionDomainHelixVesiclesFunctionMembraneInteraction
2016
Significance of 1B and 2B domains in modulating elastic properties of lamin A
Bera M, Ainavarapu S, Sengupta K. Significance of 1B and 2B domains in modulating elastic properties of lamin A. Scientific Reports 2016, 6: 27879. PMID: 27301336, PMCID: PMC4908593, DOI: 10.1038/srep27879.Peer-Reviewed Original ResearchConceptsLamin ASingle-molecule force spectroscopyRod domainType V intermediate filament proteinsLamin rod domainsSingle molecular levelInner nuclear membraneC-terminal domainIntermediate filament proteinsForce spectroscopyNuclear laminsLaminsNuclear membraneFilament proteinsElastic meshworkNuclear shapeMutationsComparable mechanical propertiesDomainViscoelastic behaviorSpectroscopyLaminopathiesProperties