The Pulmonary Metatranscriptome Prior to Pediatric Hematopoietic Cell Transplantation Identifies Post-HCT Lung Injury
Zinter MS, Lindemans C, Versluys B, Mayday MY, Sunshine S, Reyes G, Sirota M, Sapru A, Matthay MA, Kharbanda S, Dvorak CC, Boelens J, DeRisi JL. The Pulmonary Metatranscriptome Prior to Pediatric Hematopoietic Cell Transplantation Identifies Post-HCT Lung Injury. Blood 2020, 137: 1679-1689. PMID: 33512420, PMCID: PMC7995292, DOI: 10.1182/blood.2020009246.Peer-Reviewed Original ResearchConceptsHematopoietic cell transplantationLung injuryHCT candidatesBronchoalveolar lavagePediatric allogeneic hematopoietic cell transplantationAllogeneic hematopoietic cell transplantationRespiratory viral loadUniversity Medical Center UtrechtInnate immune activationPulmonary gene expressionLong-term survivalSeparate validation cohortT cell activationCumulative incidenceBAL fluidViral loadDisastrous complicationImmune activationValidation cohortCell transplantationLung healthMucus productionHigh incidenceIndependent cohortInjury