2020
Antimicrobial Stewardship Optimization in the Emergency Department: The Effect of Multiplex Respiratory Pathogen Testing and Targeted Educational Intervention
Durant TJS, Kubilay NZ, Reynolds J, Tarabar AF, Dembry LM, Peaper DR. Antimicrobial Stewardship Optimization in the Emergency Department: The Effect of Multiplex Respiratory Pathogen Testing and Targeted Educational Intervention. The Journal Of Applied Laboratory Medicine 2020, 5: 1172-1183. PMID: 32918445, DOI: 10.1093/jalm/jfaa130.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Bacterial AgentsAntimicrobial StewardshipEmergency Service, HospitalHumansInfluenza, HumanRespiratory Tract InfectionsConceptsAntibiotic prescription ratesEmergency departmentPrescription ratesAntibiotic prescriptionsED visitsRespiratory pathogen testingRespiratory tract infectionsAdult emergency departmentAntimicrobial treatment decisionsProvider-patient interactionsDetection of influenzaTargeted educational interventionsAntimicrobial stewardship educationOseltamivir prescriptionsASP interventionsTract infectionsInfluenza seasonIntervention cohortTreatment decisionsPatient engagementPatientsResult availabilityCohortEducational interventionStewardship education
2019
Perspectives on antimicrobial use at the end of life among antibiotic stewardship programs: A survey of the Society for Healthcare Epidemiology of America Research Network
Datta R, Topal J, McManus D, Dembry LM, Quagliarello V, Juthani-Mehta M. Perspectives on antimicrobial use at the end of life among antibiotic stewardship programs: A survey of the Society for Healthcare Epidemiology of America Research Network. Infection Control And Hospital Epidemiology 2019, 40: 1074-1076. PMID: 31328703, PMCID: PMC7165360, DOI: 10.1017/ice.2019.194.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsAntimicrobial StewardshipDrug Utilization ReviewHumansPatient ComfortSurveys and QuestionnairesTerminal CareUnited StatesAntimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfection
2016
The clinical and molecular epidemiology of pre‐transplant vancomycin‐resistant enterococci colonization among liver transplant recipients
Banach DB, Peaper DR, Fortune BE, Emre S, Dembry LM. The clinical and molecular epidemiology of pre‐transplant vancomycin‐resistant enterococci colonization among liver transplant recipients. Clinical Transplantation 2016, 30: 306-311. PMID: 26780305, DOI: 10.1111/ctr.12690.Peer-Reviewed Original ResearchConceptsLiver transplant recipientsLiver transplantationVRE colonizationTransplant recipientsVancomycin-resistant enterococci (VRE) infectionPolymerase chain reaction testingVancomycin-resistant enterococci colonizationPre-transplant colonizationSubsequent liver transplantationMore hospital daysObservational cohort studyCentral venous catheterizationInfection prevention measuresWarrants further studyRifaximin useAntimicrobial prophylaxisCohort studyHospital daysSignificant morbidityVenous catheterizationProspective studyActive surveillanceRisk factorsSurveillance culturesVRE isolates
2011
Granulicatella adiacens and Early-Onset Sepsis in Neonate - Volume 17, Number 10—October 2011 - Emerging Infectious Diseases journal - CDC
Bizzarro MJ, Callan DA, Farrel PA, Dembry LM, Gallagher PG. Granulicatella adiacens and Early-Onset Sepsis in Neonate - Volume 17, Number 10—October 2011 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2011, 17: 1971-1973. PMID: 22000391, PMCID: PMC3310662, DOI: 10.3201/eid1710.101967.Peer-Reviewed Original Research
2007
Trends in Prescribing β-Lactam Antibiotics for Treatment of Community-Associated Methicillin-Resistant Staphylococcus aureus Infections
Gupta K, MacIntyre A, Vanasse G, Dembry LM. Trends in Prescribing β-Lactam Antibiotics for Treatment of Community-Associated Methicillin-Resistant Staphylococcus aureus Infections. Journal Of Clinical Microbiology 2007, 45: 3930-3934. PMID: 17942648, PMCID: PMC2168566, DOI: 10.1128/jcm.01510-07.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnti-Bacterial AgentsBeta-LactamsChildChild, PreschoolCommunity-Acquired InfectionsDrug PrescriptionsFemaleHealth Services ResearchHumansInfantInfant, NewbornMaleMethicillin ResistanceMiddle AgedPrevalenceStaphylococcal InfectionsStaphylococcus aureusUnited StatesConceptsCA-MRSA soft tissue infectionsSoft tissue infectionsInitial empirical therapyCA-MRSA isolatesEmpirical therapyAntimicrobial therapyCommunity-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) isolatesStaphylococcal chromosomal cassette mec type IVS. aureus soft tissue infectionsResistant Staphylococcus aureus infectionsMethicillin-Resistant Staphylococcus aureus IsolatesInactive antimicrobial therapyRate of prescribingCA-MRSA infectionsInitial antimicrobial therapyMajority of patientsMedical record reviewSubset of patientsCommunity-Associated MethicillinStaphylococcus aureus infectionPanton-Valentine leukocidinStaphylococcus aureus isolatesBeta-lactam antibioticsDiscordant therapyRate of use
2004
Approaches to vancomycin-resistant enterococci
Torres-Viera C, Dembry LM. Approaches to vancomycin-resistant enterococci. Current Opinion In Infectious Diseases 2004, 17: 541-547. PMID: 15640708, DOI: 10.1097/00001432-200412000-00006.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsEnterococcusGram-Positive Bacterial InfectionsHumansVancomycin ResistanceConceptsVancomycin-resistant enterococciVancomycin-resistant enterococci colonizationNew drugsSerious enterococcal infectionsLimited clinical dataInfection control practicesVitro bactericidal activityLipopeptide antimicrobialBloodstream infectionsClinical trialsEnterococcal infectionsOral administrationClinical dataInfectionAntimicrobial drugsBactericidal activityPhase IIDrugsEnterococciTreatmentNew antimicrobial drugsStrict guidelinesTrialsControl practicesBacterial isolates
2003
Emergence of linezolid-resistant Enterococcus faecium during treatment of enterococcal infections
Bassetti M, Farrel PA, Callan DA, Topal JE, Dembry LM. Emergence of linezolid-resistant Enterococcus faecium during treatment of enterococcal infections. International Journal Of Antimicrobial Agents 2003, 21: 593-594. PMID: 12791477, DOI: 10.1016/s0924-8579(03)00090-6.Peer-Reviewed Original Research
2002
Antimicrobial Activities of BMS-284756 Compared with Those of Fluoroquinolones and β-Lactams against Gram-Positive Clinical Isolates
Bassetti M, Dembry L, Farrel P, Callan D, Andriole V. Antimicrobial Activities of BMS-284756 Compared with Those of Fluoroquinolones and β-Lactams against Gram-Positive Clinical Isolates. Antimicrobial Agents And Chemotherapy 2002, 46: 234-238. PMID: 11751142, PMCID: PMC126992, DOI: 10.1128/aac.46.1.234-238.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsAnti-Infective AgentsBeta-LactamsFluoroquinolonesGram-Positive BacteriaHumansIndolesMicrobial Sensitivity TestsQuinolonesConceptsBMS-284756Clinical isolatesGram-positive clinical isolatesResistant coagulase-negative staphylococciBeta-hemolytic streptococciAmoxicillin-clavulanic acidPositive clinical isolatesResistant Staphylococcus aureusCoagulase-negative staphylococciPiperacillin-tazobactamStreptococcus viridansStreptococcus pneumoniaeStaphylococcus aureusΒ-lactamsActive agentsIsolatesCeftriaxoneAntibacterial activityImipenemMoxifloxacinPneumoniaeViridansFluoroquinolones
2001
Comparative antimicrobial activity of gatifloxacin with ciprofloxacin and beta-lactams against gram-positive bacteria
Bassetti M, Dembry L, Farrel P, Callan D, Andriole V. Comparative antimicrobial activity of gatifloxacin with ciprofloxacin and beta-lactams against gram-positive bacteria. Diagnostic Microbiology And Infectious Disease 2001, 41: 143-148. PMID: 11750168, DOI: 10.1016/s0732-8893(01)00298-x.Peer-Reviewed Original ResearchConceptsAmoxicillin/clavulanic acidPiperacillin/tazobactamClavulanic acidMethicillin-susceptible S. aureusPenicillin-nonsusceptible Streptococcus pneumoniaeMethicillin-sensitive S. epidermidisMethicillin-resistant coagulase-negative staphylococciGram-positive infectionsViridans group streptococciCoagulase-negative staphylococciPromising new fluoroquinoloneActive agentsNew fluoroquinoloneStreptococcal isolatesGroup streptococciVitro antibacterial activityClinical isolatesStreptococcus pneumoniaeComparative antimicrobial activityStaphylococcal isolatesClinical useEnterococcal isolatesImipenemGatifloxacinE. faecalis
2000
Molecular Typing Demonstrating Transmission of Gram-Negative Rods in a Neonatal Intensive Care Unit in the Absence of a Recognized Epidemic
Almuneef M, Baltimore R, Farrel P, Reagan-Cirincione P, Dembry L. Molecular Typing Demonstrating Transmission of Gram-Negative Rods in a Neonatal Intensive Care Unit in the Absence of a Recognized Epidemic. Clinical Infectious Diseases 2000, 32: 220-227. PMID: 11170911, DOI: 10.1086/318477.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBacterial Typing TechniquesCross InfectionDNA, BacterialDrug Resistance, MicrobialElectrophoresisFecesFemaleGenotypeGentamicinsGram-Negative Aerobic Rods and CocciGram-Negative Bacterial InfectionsHumansInfantInfant, NewbornIntensive Care Units, NeonatalMaleMicrobial Sensitivity TestsConceptsNeonatal intensive care unitIntensive care unitShared strainsCare unitMolecular typing techniquesRectal swab culturesColonization of infantsGentamicin-resistant strainsWeeks of ageTyping techniquesAntibiotic treatmentAntibiotic useSwab culturesGram-negative rodsGentamicin susceptibilityInfantsTotal daysOutbreak investigationIdentical strainsNegative rodsUnique strainsHigh rateContour-clamped homogeneous electric field electrophoresisAdmissionGentamicin
1998
Molecular Analysis of Glycopeptide-ResistantEnterococcus faecium Isolates Collected from Michigan Hospitals over a 6-Year Period
Thal L, Donabedian S, Robinson-Dunn B, Chow J, Dembry L, Clewell D, Alshab D, Zervos M. Molecular Analysis of Glycopeptide-ResistantEnterococcus faecium Isolates Collected from Michigan Hospitals over a 6-Year Period. Journal Of Clinical Microbiology 1998, 36: 3303-3308. PMID: 9774583, PMCID: PMC105319, DOI: 10.1128/jcm.36.11.3303-3308.1998.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBacterial Typing TechniquesChromosomes, BacterialCross InfectionDNA, BacterialDrug Resistance, MicrobialElectrophoresis, Gel, Pulsed-FieldEnterococcus faeciumGene Transfer TechniquesGenes, BacterialGram-Positive Bacterial InfectionsHumansMichiganMolecular EpidemiologyNucleic Acid HybridizationPlasmidsVancomycinConceptsExtended-care facilityPulsed-field gel electrophoresisEnterococcus faecium isolatesFaecium isolatesClonal disseminationVancomycin-resistant E. faeciumStrain typesE. faecium isolatesVancomycin-resistant E. faecium isolatesIntrahospital disseminationSpread of resistanceMichigan hospitalsMajority of isolatesPatientsHospitalClinical isolatesGentamicin resistanceVanA geneErythromycin resistanceE. faeciumVancomycin resistanceType M2VanB genesMolecular relatednessMost isolatesComparison of In Vitro Activity of Trovafloxacin Against Gram-positive and Gram-negative Organisms with Quinolones and β-Lactam Antimicrobial Agents
Dembry L, Roberts J, Schock K, Marino S, Farrel P, Andriole V. Comparison of In Vitro Activity of Trovafloxacin Against Gram-positive and Gram-negative Organisms with Quinolones and β-Lactam Antimicrobial Agents. Diagnostic Microbiology And Infectious Disease 1998, 31: 301-311. PMID: 9597391, DOI: 10.1016/s0732-8893(98)00004-2.Peer-Reviewed Original Research
1997
RENAL AND PERIRENAL ABSCESSES
Dembry LM, Andriole VT. RENAL AND PERIRENAL ABSCESSES. Infectious Disease Clinics Of North America 1997, 11: 663-680. PMID: 9378929, DOI: 10.1016/s0891-5520(05)70379-2.Peer-Reviewed Original ResearchConceptsRenal cortical abscessCortical abscessesIntrarenal abscessAntibiotic therapyAcute multifocal bacterial nephritisAcute focal bacterial nephritisFocal bacterial nephritisRenal corticomedullaryPerirenal abscessRenal abscessSerious prognosisXanthogranulomatous pyelonephritisClinical presentationElusive diagnosisNegative uropathogensAntistaphylococcal therapyComplete nephrectomyAbscessRadiographic studiesRadiologic techniquesTherapyNephritisDiagnosisPyelonephritisNephrectomy
1996
Control of endemic glycopeptide-resistant enterococci.
Dembry LM, Uzokwe K, Zervos MJ. Control of endemic glycopeptide-resistant enterococci. Infection Control And Hospital Epidemiology 1996, 17: 286-92. PMID: 8727617, DOI: 10.1086/647297.Peer-Reviewed Original ResearchConceptsVancomycin-resistant EnterococcusRenal unitsEradication of carriageVRE stool colonizationCommunity teaching hospitalPatient carriageBarrier precautionsOral doxycyclineFurther patientsStool colonizationGlycopeptide-resistant enterococciCulture surveyTeaching hospitalPatientsStudy periodEnterococcus faeciumEnterococcus gallinarumCarriageRifampinDoxycyclineEnterococcusControl measuresDaysUseful measureHospitalComparison of rectal and perirectal swabs for detection of colonization with vancomycin-resistant enterococci
Weinstein JW, Tallapragada S, Farrel P, Dembry LM. Comparison of rectal and perirectal swabs for detection of colonization with vancomycin-resistant enterococci. Journal Of Clinical Microbiology 1996, 34: 210-212. PMID: 8748308, PMCID: PMC228765, DOI: 10.1128/jcm.34.1.210-212.1996.Peer-Reviewed Original Research